Quantitative Proteomics of Medium-Sized Extracellular Vesicle (MEV) -Enriched Plasma of Lacunar Infarction for the Discovery of Prognostic Biomarkers

This database provides the shortlist of 146 altered plasma MEV-enriched proteins in lacunar infarction (LACI) patients with various outcome measures (NAO - no adverse outcome, RVE - recurrent vascular event, CD - cognitive decline) when compared to matched healthy control (HC) subjects. The data was generated by an 4-plex iTRAQ experiment on MEV-enriched pooled plama samples obtained from the above 4 groups of subjects.

Sample collection and clinical Information: The basline plasma samples of a total of 45 LACI patients were obtained from the cognitive sub-study of European Australasian Stroke Prevention in Reversible Ischemia Trial (ESPRIT-cog). Patients were eligible if they were within 6 months of a LACI. The control plasma was obtained from demographically matched 17 healthy subjects recruited at the same site. All patients underwent a neuropsychological test battery to determine their cognitive status to exclude any patients with dementia at the baseline. Data on various baseline risk factors were collected. All subjects were followed up annually for up to 5 yrs to monitor for the occurrence of any vascular event or for a change in the baseline cognitive status. For RVE group (n=11), the patients had stroke, peripheral artery disease, intracranial bleeds, or any cardiac ischemia (stable and unstable angina, myocardial infarctions) or death from any of the above. For CD group (n=15), the cognitive status of these patients declined from the respective baseline status during follow-up visits. For NAO group (n=19), patients did not suffer a recurrent vascular event or cognitive decline. The plasma samples were pooled group-wise before isolation of MEV-enriched samples.(PMID: 24752076)

Brief proteomics method: MEV-enriched samples were obtained by combining 12000g and 30000g fractions. The samples (83 µg/group) were redcued, alkylated and digested in-gel overnight with sequencing-grade modified trypsin (12.5 ng/μl). The peptides were labeled with 4-plex iTRAQ reagents, combined and fractionated off-line with Electrostatic Repulsion and Hydrophilic Interaction Chromatography. Protein mass spectrometry was performed on individual fractions with QSTAR Elite Hybrid MS. Analyst QS 2.0 software (Applied Biosystems) was used for the spectral data acquisition. (PMID: 26966714)

Data analysis: ProteinPilot Software 3.0, Revision Number: 114 732 (Applied Biosystems) was used for the peak list generation, protein identification and quantification against the concatenated target-decoy Uniprot human database (191242 sequences). The false discovery rate (FDR) of peptide identification was set to be less than 1%. The dataset was corrected for bias and background in ProteinPilot. Protein identification score, number of 95% confident peptides detected for each protein, and %sequence coverage attained by 95% confident peptides are presented for each protein under identification parameters. Proteins were considered changed in abundance if they met the following criteria for each group (i.e. NAO/HC, RVE/HC and CD/HC): |Log2(ratio) |>0.585 and (-log10(p-value))>1.301. This is equivalent to a fold change of 1.5-fold and a p-value of 0.05. A total of 146 out 573 proteins were significantly altered based on this dual criteria. The log ratios of altered proteins are color-coded: increased, Red; decreased, Blue.

Reference: Datta, A., Chen, C., Gao, Y. G., and Sze, S. K. (2022) Int. J. Mol. Sci. 23, 11670

The website was created by Arnab Datta. Please contact Arnab Datta at arnabdattaju@gmail.com, arnabdatta@yenepoya.edu.in or Siu Kwan Sze at nsze@brocku.ca for comments or questions.

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Gene Symbol Accession Protein Name Identification Parameters NAO/HC RVE/HC CD/HC
Protein Score %Cov(95) Peptides (95%) Log2(ratio) P-Value Log2(ratio) P-Value Log2(ratio) P-Value
HBA1   P69905 Hemoglobin subunit alpha  24.6 68.3 28 2.23 0.002 3.49 0.000 3.68 0.000
LPA   P08519 Apolipoprotein(a)  46.5 29.2 38 1.36 0.000 0.05 0.718 -0.48 0.492
HBB   P68871 Hemoglobin subunit beta  34.8 95.2 41 1.29 0.021 2.70 0.001 2.58 0.001
C3   P01024 Complement C3  200.7 56.2 168 1.22 0.000 0.77 0.019 2.03 0.000
ALB   P02768 Serum albumin  258.4 85.5 399 1.21 0.000 -2.75 0.000 0.05 0.487
SLC4A1   P02730 Band 3 anion transport protein  98.1 41.8 99 1.05 0.000 -3.16 0.000 -1.05 0.000
SLC2A1   P11166 Solute carrier family 2, facilitated glucose transporter member 1  10.6 13.2 6 1.04 0.079 -2.75 0.010 -1.00 0.128
ITIH4   Q14624 Inter-alpha-trypsin inhibitor heavy chain H4  36.3 22.5 17 1.02 0.003 1.33 0.001 0.60 0.021
EPB41 P11171-2 Isoform 2 of Protein 4.1  39.8 30.6 21 0.98 0.007 -2.48 0.001 -0.60 0.156
EPB42   P16452 Erythrocyte membrane protein band 4.2  29.5 19.0 16 0.96 0.000 -1.53 0.000 -0.72 0.132
ANK1 P16157-14 Isoform Er13 of Ankyrin-1  145.5 45.4 110 0.94 0.000 -2.25 0.000 -0.41 0.001
PON1   P27169 Serum paraoxonase/arylesterase 1  20.0 39.7 11 0.82 0.005 -0.39 0.181 -0.29 0.200
HPX   P02790 Hemopexin  19.3 21.9 10 0.82 0.033 -0.90 0.022 0.11 0.706
SPTB P11277-2 Isoform 2 of Spectrin beta chain, erythrocytic  200.6 50.1 129 0.80 0.000 -3.20 0.000 -0.53 0.000
SPTA1   P02549 Spectrin alpha chain, erythrocytic 1  230.4 57.0 138 0.73 0.000 -2.96 0.000 -0.36 0.000
ITIH2   P19823 Inter-alpha-trypsin inhibitor heavy chain H2  23.3 15.0 12 0.72 0.051 0.12 0.872 1.18 0.002
KNG1 P01042-2 Isoform LMW of Kininogen-1  23.1 28.6 12 0.69 0.029 -1.02 0.018 0.24 0.473
CAT   P04040 Catalase  17.6 22.8 8 0.61 0.046 -0.23 0.886 0.16 0.671
TF   P02787 Serotransferrin  75.2 52.6 57 0.58 0.003 -1.95 0.000 0.07 0.595
CP   P00450 Ceruloplasmin  44.5 27.4 24 0.52 0.125 0.04 0.766 1.37 0.000
C5   P01031 Complement C5  21.9 8.7 11 0.48 0.131 0.11 0.745 0.64 0.017
ADD1 P35611-3 Isoform 3 of Alpha-adducin  13.4 9.8 6 0.39 0.141 -1.85 0.036 0.00 0.716
SERPINA1   P01009 Alpha-1-antitrypsin  45.2 55.5 32 0.33 0.075 -1.47 0.000 -0.09 0.911
HP   P00738 Haptoglobin  73.8 64.5 92 0.29 0.197 2.33 0.000 2.22 0.000
FCN3   O75636 Ficolin-3  48.3 64.9 87 0.27 0.520 -1.00 0.016 -0.93 0.020
IQGAP2   Q13576 Ras GTPase-activating-like protein IQGAP2  10.9 1.8 3 0.25 0.051 -1.10 0.002 -2.02 0.001
APOE   P02649 Apolipoprotein E  40.1 68.4 25 0.13 0.438 -0.72 0.064 -0.94 0.037
STOM   P27105 Erythrocyte band 7 integral membrane protein  27.0 50.0 20 -0.07 0.592 -0.82 0.008 -1.34 0.002
BCHE   P06276 Cholinesterase  7.2 7.0 3 -0.12 0.365 2.18 0.014 2.39 0.008
PROS1   P07225 Vitamin K-dependent protein S  11.9 10.8 6 -0.13 0.375 1.16 0.029 1.24 0.027
MSN   P26038 Moesin  29.6 28.4 17 -0.17 0.353 -1.73 0.043 -0.44 0.269
FGA   P02671 Fibrinogen alpha chain  105.5 42.8 152 -0.19 0.044 -3.56 0.000 0.33 0.008
C4BPA   P04003 C4b-binding protein alpha chain  28.1 28.3 19 -0.23 0.315 1.22 0.000 1.42 0.000
VTN   P04004 Vitronectin  17.5 20.9 13 -0.23 0.265 -1.82 0.003 -0.78 0.195
APOH   P02749 Beta-2-glycoprotein 1  14.5 28.1 12 -0.27 0.367 -2.76 0.002 -1.75 0.007
IGKC   P01834 Immunoglobulin kappa constant  54.5 91.6 123 -0.28 0.266 0.40 0.415 1.94 0.000
F5   A0A0A0MRJ7 Coagulation factor V  47.3 11.9 22 -0.29 0.095 -2.13 0.000 -1.29 0.000
ATP5A1   P25705 ATP synthase subunit alpha, mitochondrial  18.3 21.2 9 -0.31 0.102 -1.81 0.005 -1.90 0.018
DIAPH1   A0A0G2JH68 Protein diaphanous homolog 1  10.9 5.0 5 -0.33 0.294 -2.10 0.001 -1.74 0.003
FLOT2   E7EMK3 Flotillin-2  14.2 18.0 7 -0.35 0.373 -1.54 0.007 -0.62 0.111
UBA52   P62987 Ubiquitin-60S ribosomal protein L40  7.4 29.7 3 -0.36 0.359 -1.54 0.036 -0.53 0.258
DYNC1H1   Q14204 Cytoplasmic dynein 1 heavy chain 1  6.9 0.4 2 -0.40 0.312 -0.98 0.050 -1.04 0.023
VWF   P04275 von Willebrand factor  48.7 9.7 28 -0.43 0.008 -1.09 0.000 1.49 0.000
CANX P27824-2 Isoform 2 of Calnexin  8.3 8.0 4 -0.44 0.192 -2.39 0.016 -2.03 0.127
PECAM1 P16284-6 Isoform Delta15 of Platelet endothelial cell adhesion molecule  11.6 10.0 5 -0.45 0.387 -1.21 0.035 -1.61 0.019
GP5   P40197 Platelet glycoprotein V  27.7 33.6 17 -0.45 0.078 -2.15 0.000 -1.90 0.000
MYLK Q15746-5 Isoform 4 of Myosin light chain kinase, smooth muscle  8.0 2.2 4 -0.47 0.413 -1.67 0.021 -1.77 0.027
FGB   P02675 Fibrinogen beta chain  110.1 81.9 118 -0.48 0.215 -3.48 0.000 0.28 0.238
FGG   P02679 Fibrinogen gamma chain  69.2 61.6 99 -0.49 0.131 -2.56 0.000 0.43 0.302
GANAB   Q14697 Neutral alpha-glucosidase AB  11.7 9.7 6 -0.53 0.162 -1.25 0.012 -1.50 0.005
KIF2A O00139-4 Isoform 4 of Kinesin-like protein KIF2A  8.4 6.5 4 -0.53 0.197 -1.99 0.017 -1.38 0.050
ITGB3   P05106 Integrin beta-3  32.8 22.8 21 -0.56 0.002 -2.26 0.000 -2.13 0.000
AP2B1 P63010-2 Isoform 2 of AP-2 complex subunit beta  7.1 2.7 3 -0.57 0.230 -2.13 0.016 -1.01 0.140
KLKB1   H0YAC1 Plasma kallikrein (Fragment)  8.4 6.7 4 -0.58 0.258 -0.50 0.543 1.09 0.043
FLII   Q13045 Protein flightless-1 homolog  4.6 1.9 2 -0.58 0.339 -2.11 0.040 -2.86 0.029
ITGA2B   P08514 Integrin alpha-IIb  74.4 35.2 71 -0.60 0.000 -1.74 0.000 -1.83 0.000
P4HB   P07237 Protein disulfide-isomerase  7.0 10.0 3 -0.60 0.328 -2.51 0.038 -2.17 0.048
CLTC   Q00610 Clathrin heavy chain 1  41.3 15.5 20 -0.60 0.023 -2.23 0.000 -2.62 0.000
CD36   E7EU05 Platelet glycoprotein 4 (Fragment)  17.6 16.9 9 -0.61 0.027 -1.45 0.003 -1.54 0.004
VCP   P55072 Transitional endoplasmic reticulum ATPase  43.9 36.6 21 -0.61 0.045 0.09 0.921 0.08 0.437
SACM1L   Q9NTJ5 Phosphatidylinositide phosphatase SAC1  9.1 8.7 4 -0.62 0.089 -3.51 0.000 -2.26 0.002
VASP   P50552 Vasodilator-stimulated phosphoprotein  15.0 19.7 7 -0.64 0.378 -3.36 0.002 -1.42 0.024
RASA3   Q14644 Ras GTPase-activating protein 3  17.9 11.3 8 -0.64 0.056 -1.77 0.005 -1.86 0.017
RPN1   P04843 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1  6.1 8.6 3 -0.65 0.256 -2.15 0.025 -1.55 0.032
ACTR3   P61158 Actin-related protein 3  10.9 17.0 5 -0.66 0.087 -2.02 0.028 -1.55 0.035
HSP90B1   P14625 Endoplasmin  13.4 9.2 6 -0.68 0.099 -2.68 0.001 -1.59 0.004
CTTN   Q14247 Src substrate cortactin  6.1 5.5 3 -0.68 0.194 -2.39 0.021 -2.68 0.018
THBS1   P07996 Thrombospondin-1  72.8 31.0 51 -0.68 0.000 -3.59 0.000 -2.99 0.000
CD5L   O43866 CD5 antigen-like  25.6 41.2 16 -0.69 0.035 0.74 0.021 1.99 0.000
NNT   Q13423 NAD(P) transhydrogenase, mitochondrial  11.4 5.0 5 -0.69 0.176 -1.89 0.108 -2.92 0.025
DNM1L   O00429 Dynamin-1-like protein  10.1 6.8 4 -0.74 0.069 -2.38 0.001 -2.62 0.045
HSD17B4   P51659 Peroxisomal multifunctional enzyme type 2  11.6 10.3 6 -0.76 0.111 -2.39 0.005 -2.23 0.009
TBXAS1   A0A0C4DH47 Thromboxane-A synthase  7.8 5.7 3 -0.76 0.254 -2.22 0.053 -2.72 0.026
ATP5B   P06576 ATP synthase subunit beta, mitochondrial  38.6 35.7 20 -0.77 0.117 -2.14 0.000 -1.89 0.000
HSPA5   P11021 78 kDa glucose-regulated protein  15.9 16.7 8 -0.77 0.034 -3.34 0.000 -2.58 0.000
GSN   P06396 Gelsolin  32.3 22.4 19 -0.78 0.000 -2.74 0.000 -2.27 0.000
FERMT3 Q86UX7-2 Isoform 2 of Fermitin family homolog 3  42.7 41.3 23 -0.78 0.000 -1.94 0.000 -2.70 0.000
ATP2A3 Q93084-5 Isoform SERCA3E of Sarcoplasmic/endoplasmic reticulum calcium ATPase 3  17.9 10.6 10 -0.78 0.067 -2.71 0.001 -3.51 0.000
APOA1   P02647 Apolipoprotein A-I  39.2 56.9 23 -0.80 0.342 -1.40 0.017 0.96 0.005
EHD1   A0A024R571 EH domain-containing protein 1  10.1 5.7 4 -0.80 0.347 -1.83 0.009 -2.11 0.014
ENO1   P06733 Alpha-enolase  13.2 19.6 9 -0.81 0.308 -1.46 0.042 -1.75 0.031
PLEC   Q15149 Plectin  43.4 4.5 18 -0.81 0.000 -2.46 0.000 -2.22 0.000
MMRN1   Q13201 Multimerin-1  36.6 17.6 22 -0.81 0.000 -3.10 0.000 -2.46 0.000
ITGA6   P23229 Integrin alpha-6  19.2 10.3 11 -0.82 0.007 -0.66 0.031 -2.05 0.000
F13A1   P00488 Coagulation factor XIII A chain  18.5 14.5 13 -0.82 0.029 -2.80 0.000 -2.55 0.000
CAPZA1   P52907 F-actin-capping protein subunit alpha-1  12.1 25.9 6 -0.82 0.197 -3.45 0.033 -3.18 0.032
FN1 P02751-15 Isoform 15 of Fibronectin  101.6 27.5 67 -0.85 0.010 0.76 0.000 1.54 0.000
IGHA1   P01876 Immunoglobulin heavy constant alpha 1  52.9 56.9 68 -0.85 0.388 -0.07 0.755 1.16 0.040
ITGB1   P05556 Integrin beta-1  18.1 13.3 10 -0.85 0.020 -1.37 0.002 -1.10 0.014
FHOD1   Q9Y613 FH1/FH2 domain-containing protein 1  6.0 3.4 3 -0.85 0.224 -3.85 0.030 -2.38 0.093
PIGR   P01833 Polymeric immunoglobulin receptor  11.3 10.9 6 -0.88 0.482 1.14 0.062 1.70 0.026
CS   O75390 Citrate synthase, mitochondrial  4.6 4.5 2 -0.89 0.190 -1.98 0.049 -1.69 0.063
HSPA8   P11142 Heat shock cognate 71 kDa protein  26.5 24.2 13 -0.92 0.084 -2.95 0.004 -1.95 0.040
HADHA   P40939 Trifunctional enzyme subunit alpha, mitochondrial  5.2 5.4 3 -0.92 0.206 -2.22 0.069 -2.47 0.044
PCBP1   Q15365 Poly(rC)-binding protein 1  5.7 9.8 3 -0.92 0.125 -3.43 0.010 -1.66 0.153
PARVB Q9HBI1-2 Isoform 2 of Beta-parvin  19.2 27.2 10 -0.93 0.048 -2.02 0.003 -2.25 0.002
TUBA4A   P68366 Tubulin alpha-4A chain  37.5 55.1 29 -0.93 0.151 -2.94 0.012 -3.83 0.010
INF2   Q27J81 Inverted formin-2  17.8 9.9 8 -0.94 0.051 -4.62 0.000 -2.39 0.003
CORO1C Q9ULV4-3 Isoform 3 of Coronin-1C  19.2 24.1 9 -0.94 0.005 -3.00 0.000 -2.46 0.000
PDIA3   P30101 Protein disulfide-isomerase A3  17.3 18.8 8 -0.94 0.004 -3.22 0.000 -2.58 0.000
PLEK   P08567 Pleckstrin  12.0 23.7 6 -0.96 0.120 -1.86 0.025 -1.87 0.022
HSPD1   P10809 60 kDa heat shock protein, mitochondrial  18.1 19.0 8 -0.98 0.022 -2.47 0.000 -2.01 0.001
CAVIN2   O95810 Caveolae-associated protein 2  16.9 28.5 9 -0.98 0.041 -3.65 0.000 -2.26 0.004
TJP2   Q9UDY2 Tight junction protein ZO-2  3.5 0.7 1 -1.00 0.106 -1.87 0.043 -1.94 0.046
PZP   P20742 Pregnancy zone protein  18.6 16.8 126 -1.04 0.067 0.01 0.753 1.53 0.003
GC   D6RF35 Vitamin D-binding protein  26.5 34.0 17 -1.04 0.001 -2.59 0.000 -1.42 0.000
IDH2   P48735 Isocitrate dehydrogenase [NADP], mitochondrial  17.8 20.6 8 -1.04 0.002 -3.06 0.000 -2.44 0.000
GP1BA   A0A0C4DGZ8 Glycoprotein Ib (Platelet), alpha polypeptide  25.2 17.4 11 -1.04 0.002 -2.23 0.000 -2.68 0.000
LTBP1 Q14766-4 Isoform 4 of Latent-transforming growth factor beta-binding protein 1  13.4 5.0 6 -1.10 0.010 -3.03 0.000 -2.19 0.001
LGALS3BP   Q08380 Galectin-3-binding protein  35.9 34.4 23 -1.12 0.001 1.10 0.001 2.03 0.000
ITGA2   P17301 Integrin alpha-2  16.6 8.4 8 -1.12 0.010 -2.02 0.002 -2.05 0.001
RAP1B   P61224 Ras-related protein Rap-1b  10.9 25.5 5 -1.20 0.043 -1.18 0.071 -1.25 0.045
VCL   P18206 Vinculin  72.5 37.6 46 -1.21 0.000 -2.09 0.000 -2.33 0.000
C1R   B4DPQ0 Complement C1r subcomponent  23.6 23.8 11 -1.21 0.012 -0.72 0.058 0.43 0.281
MYL12B   O14950 Myosin regulatory light chain 12B  8.0 23.8 4 -1.28 0.135 -2.79 0.044 -1.75 0.081
ALDOA P04075-2 Isoform 2 of Fructose-bisphosphate aldolase A  7.9 7.2 3 -1.28 0.045 -2.92 0.008 -2.68 0.012
CAP1   Q01518 Adenylyl cyclase-associated protein 1  16.5 20.2 8 -1.29 0.049 -2.82 0.002 -2.91 0.006
KRT10   P13645 Keratin, type I cytoskeletal 10  39.7 48.5 41 -1.30 0.000 -2.42 0.000 -1.53 0.000
ZYX   Q15942 Zyxin  14.3 17.3 8 -1.30 0.008 -2.52 0.001 -2.54 0.001
PFN1   P07737 Profilin-1  13.4 50.7 9 -1.32 0.066 -1.70 0.005 -1.61 0.006
ESYT1 Q9BSJ8-2 Isoform 2 of Extended synaptotagmin-1  9.0 4.4 4 -1.32 0.241 -2.63 0.019 -2.82 0.020
APOL1   O14791 Apolipoprotein L1  25.3 34.7 14 -1.33 0.024 0.25 0.962 1.91 0.000
TUBB1   Q9H4B7 Tubulin beta-1 chain  31.0 60.5 32 -1.34 0.000 -3.81 0.000 -2.78 0.000
MYL6   B7Z6Z4 Myosin light polypeptide 6  4.8 12.2 4 -1.36 0.097 -3.00 0.039 -3.43 0.038
FCGBP   Q9Y6R7 IgGFc-binding protein  19.0 3.1 9 -1.37 0.038 1.37 0.017 2.48 0.000
ACTN1 P12814-3 Isoform 3 of Alpha-actinin-1  68.4 42.1 45 -1.40 0.000 -3.59 0.000 -3.20 0.000
GAPDH   P04406 Glyceraldehyde-3-phosphate dehydrogenase  22.8 39.1 15 -1.44 0.001 -2.14 0.000 -1.44 0.001
ILK   Q13418 Integrin-linked protein kinase  23.0 27.4 16 -1.45 0.000 -2.42 0.000 -2.09 0.000
GP1BB P13224-2 Isoform 2 of Platelet glycoprotein Ib beta chain  7.9 7.8 4 -1.50 0.097 -2.84 0.050 -2.15 0.048
TFRC   P02786 Transferrin receptor protein 1  19.5 14.2 9 -1.77 0.002 -0.27 0.298 0.01 0.870
RSU1   Q15404 Ras suppressor protein 1  18.6 45.5 9 -1.78 0.001 -1.69 0.001 -1.83 0.001
PKM   P14618 Pyruvate kinase PKM  33.7 41.0 18 -1.82 0.000 -2.63 0.000 -2.23 0.000
AHNAK   Q09666 Neuroblast differentiation-associated protein AHNAK  12.7 2.9 5 -1.86 0.083 -2.88 0.043 -1.70 0.079
ROCK2   O75116 Rho-associated protein kinase 2  6.2 2.1 2 -1.89 0.156 -1.93 0.093 -2.78 0.018
PDLIM1   O00151 PDZ and LIM domain protein 1  8.0 17.0 4 -2.42 0.062 -2.51 0.037 -2.68 0.033
HPR   A0A0A0MRD9 Haptoglobin-related protein  12.3 55.5 39 -2.50 0.283 1.04 0.167 2.50 0.040
HIST1H4A   P62805 Histone H4  6.9 26.2 3 -2.51 0.020 -1.71 0.045 -1.24 0.077
KRT9   P35527 Keratin, type I cytoskeletal 9  39.0 50.2 42 -3.31 0.000 -3.31 0.000 -2.03 0.000
KRT6A   P02538 Keratin, type II cytoskeletal 6A  8.7 55.0 57 -3.43 0.011 -4.04 0.008 -2.68 0.021
IGHM   P01871 Immunoglobulin heavy constant mu  192.7 69.1 390 -4.07 0.000 1.30 0.001 2.62 0.000
JUP   P14923 Junction plakoglobin  12.0 7.2 5 -4.08 0.000 -4.31 0.000 -3.72 0.000
KRT1   P04264 Keratin, type II cytoskeletal 1  90.7 55.6 67 -4.25 0.000 -4.41 0.000 -2.48 0.000
KRT17   Q04695 Keratin, type I cytoskeletal 17  21.3 47.9 27 -4.46 0.004 -4.27 0.000 -2.87 0.000
KRT14   P02533 Keratin, type I cytoskeletal 14  33.7 60.6 49 -4.93 0.012 -5.90 0.000 -4.65 0.001
KRT5   P13647 Keratin, type II cytoskeletal 5  17.0 30.2 31 -5.45 0.001 -5.33 0.000 -3.73 0.000
KRT16   P08779 Keratin, type I cytoskeletal 16  69.6 63.0 75 -5.73 0.000 -5.78 0.000 -4.81 0.000
Gene Symbol Accession Protein Name Identification Parameters NAO/HC RVE/HC CD/HC
Protein Score %Cov(95) Peptides (95%) Log2(ratio) P-Value Log2(ratio) P-Value Log2(ratio) P-Value
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This raw data can be found at PRIDE using the dataset identifier PXD032225

Pubmed | Uniprot

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