Quantitative Proteomics of Medium-Sized Extracellular Vesicle (MEV) -Enriched Plasma of Lacunar Infarction for the Discovery of Prognostic Biomarkers

This database provides ratios of plasma MEV-enriched protein abundances of lacunar infarction (LACI) patients with various outcome measures (NAO - no adverse outcome, RVE - recurrent vascular event, CD - cognitive decline) when compared to matched healthy control (HC) subjects. The data was generated by an 4-plex iTRAQ experiment on MEV-enriched pooled plama samples obtained from the above 4 groups of subjects. 

Sample collection and clinical Information: The basline plasma samples of a total of 45 LACI patients were obtained from the cognitive sub-study of European Australasian Stroke Prevention in Reversible Ischemia Trial (ESPRIT-cog). Patients were eligible if they were within 6 months of a LACI. The control plasma was obtained from demographically matched 17 healthy subjects recruited at the same site. All patients underwent a neuropsychological test battery to determine their cognitive status to exclude any patients with dementia at the baseline. Data on various baseline risk factors were collected. All subjects were followed up annually for up to 5 yrs to monitor for the occurrence of any vascular event or for a change in the baseline cognitive status. For RVE group (n=11), the patients had stroke, peripheral artery disease, intracranial bleeds, or any cardiac ischemia (stable and unstable angina, myocardial infarctions) or death from any of the above. For CD group (n=15), the cognitive status of these patients declined from the respective baseline status during follow-up visits. For NAO group (n=19), patients did not suffer a recurrent vascular event or cognitive decline. The plasma samples were pooled group-wise before isolation of MEV-enriched samples.(PMID: 24752076)

Brief proteomics method: MEV-enriched samples were obtained by combining 12000g and 30000g fractions. The samples (83 µg/group) were redcued, alkylated and digested in-gel overnight with sequencing-grade modified trypsin (12.5 ng/µl). The peptides were labeled with 4-plex iTRAQ reagents. The labeled peptides were combined, desalted, and fractionated off-line into 34 fractions with Electrostatic Repulsion and Hydrophilic Interaction Chromatography. Protein mass spectrometry was performed on individual fractions with QSTAR Elite Hybrid MS. Analyst QS 2.0 software (Applied Biosystems) was used for the spectral data acquisition. (PMID: 26966714)

Data analysis: ProteinPilot Software 3.0 (Applied Biosystems) was used for the peak list generation, protein identification and quantification against the concatenated target-decoy Uniprot human database (191242 sequences). The false discovery rate (FDR) of peptide identification was set to be less than 1%. The dataset was corrected for bias and background in ProteinPilot. Proteins without quantification values and without any 95% confident peptides are deleted. Protein identification score, number of 95% confident peptides detected for each protein, and %sequence coverage attained by 95% confident peptides are presented for each protein under identification parameters. The table contains 573 confidently identified proteins sorted using protein identification score.

The website was created by Arnab Datta. Please contact Arnab Datta at arnabdattaju@gmail.com, arnabdatta@yenepoya.edu.in or Siu Kwan Sze at nsze@brocku.ca for comments or questions.

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Gene Symbol Accession Protein Name Identification Parameters NAO/HC RVE/HC CD/HC
Protein Score %Cov(95) Peptides (95%) Log2(ratio) P-Value Log2(ratio) P-Value Log2(ratio) P-Value
APOB   P04114 Apolipoprotein B-100  971.1 71.4 1070 0.09 0.000 0.05 0.000 0.01 0.000
A2M   P01023 Alpha-2-macroglobulin  662.0 83.0 1112 -0.05 0.000 0.20 0.000 0.37 0.000
MYH9   P35579 Myosin-9  305.3 63.7 335 -0.21 0.000 -0.41 0.000 -0.39 0.000
FLNA P21333-2 Isoform 2 of Filamin-A  301.4 61.1 241 -0.16 0.000 -0.27 0.000 -0.27 0.000
TLN1   Q9Y490 Talin-1  271.6 64.7 258 -0.16 0.000 -0.25 0.000 -0.25 0.000
ALB   P02768 Serum albumin  258.4 85.5 399 1.21 0.000 -2.75 0.000 0.05 0.487
SPTA1   P02549 Spectrin alpha chain, erythrocytic 1  230.4 57.0 138 0.73 0.000 -2.96 0.000 -0.36 0.000
C3   P01024 Complement C3  200.7 56.2 168 1.22 0.000 0.77 0.019 2.03 0.000
SPTB P11277-2 Isoform 2 of Spectrin beta chain, erythrocytic  200.6 50.1 129 0.80 0.000 -3.20 0.000 -0.53 0.000
IGHM   P01871 Immunoglobulin heavy constant mu  192.7 69.1 390 -4.07 0.000 1.30 0.001 2.62 0.000
ANK1 P16157-14 Isoform Er13 of Ankyrin-1  145.5 45.4 110 0.94 0.000 -2.25 0.000 -0.41 0.001
C4A   P0C0L4 Complement C4-A  118.5 38.4 87 0.27 0.707 0.03 0.955 0.08 0.892
FGB   P02675 Fibrinogen beta chain  110.1 81.9 118 -0.48 0.215 -3.48 0.000 0.28 0.238
FGA   P02671 Fibrinogen alpha chain  105.5 42.8 152 -0.19 0.044 -3.56 0.000 0.33 0.008
FN1 P02751-15 Isoform 15 of Fibronectin  101.6 27.5 67 -0.85 0.010 0.76 0.000 1.54 0.000
SLC4A1   P02730 Band 3 anion transport protein  98.1 41.8 99 1.05 0.000 -3.16 0.000 -1.05 0.000
KRT1   P04264 Keratin, type II cytoskeletal 1  90.7 55.6 67 -4.25 0.000 -4.41 0.000 -2.48 0.000
TF   P02787 Serotransferrin  75.2 52.6 57 0.58 0.003 -1.95 0.000 0.07 0.595
ITGA2B   P08514 Integrin alpha-IIb  74.4 35.2 71 -0.60 0.000 -1.74 0.000 -1.83 0.000
HP   P00738 Haptoglobin  73.8 64.5 92 0.29 0.197 2.33 0.000 2.22 0.000
THBS1   P07996 Thrombospondin-1  72.8 31.0 51 -0.68 0.000 -3.59 0.000 -2.99 0.000
VCL   P18206 Vinculin  72.5 37.6 46 -1.21 0.000 -2.09 0.000 -2.33 0.000
KRT6B   P04259 Keratin, type II cytoskeletal 6B  71.0 57.5 59 -1.79 0.195 -2.19 0.161 -1.74 0.201
KRT16   P08779 Keratin, type I cytoskeletal 16  69.6 63.0 75 -5.73 0.000 -5.78 0.000 -4.81 0.000
FGG   P02679 Fibrinogen gamma chain  69.2 61.6 99 -0.49 0.131 -2.56 0.000 0.43 0.302
ACTN1 P12814-3 Isoform 3 of Alpha-actinin-1  68.4 42.1 45 -1.40 0.000 -3.59 0.000 -3.20 0.000
IGHG1   P01857 Immunoglobulin heavy constant gamma 1  60.6 51.2 106 0.96 0.349 -0.47 0.561 0.58 0.699
IGKC   P01834 Immunoglobulin kappa constant  54.5 91.6 123 -0.28 0.266 0.40 0.415 1.94 0.000
IGHA1   P01876 Immunoglobulin heavy constant alpha 1  52.9 56.9 68 -0.85 0.388 -0.07 0.755 1.16 0.040
VWF   P04275 von Willebrand factor  48.7 9.7 28 -0.43 0.008 -1.09 0.000 1.49 0.000
FCN3   O75636 Ficolin-3  48.3 64.9 87 0.27 0.520 -1.00 0.016 -0.93 0.020
F5   A0A0A0MRJ7 Coagulation factor V  47.3 11.9 22 -0.29 0.095 -2.13 0.000 -1.29 0.000
LPA   P08519 Apolipoprotein(a)  46.5 29.2 38 1.36 0.000 0.05 0.718 -0.48 0.492
SERPINA1   P01009 Alpha-1-antitrypsin  45.2 55.5 32 0.33 0.075 -1.47 0.000 -0.09 0.911
CP   P00450 Ceruloplasmin  44.5 27.4 24 0.52 0.125 0.04 0.766 1.37 0.000
TUBB   P07437 Tubulin beta chain  44.1 50.9 32 -0.45 0.580 -2.27 0.156 -2.34 0.152
VCP   P55072 Transitional endoplasmic reticulum ATPase  43.9 36.6 21 -0.61 0.045 0.09 0.921 0.08 0.437
PLEC   Q15149 Plectin  43.4 4.5 18 -0.81 0.000 -2.46 0.000 -2.22 0.000
FERMT3 Q86UX7-2 Isoform 2 of Fermitin family homolog 3  42.7 41.3 23 -0.78 0.000 -1.94 0.000 -2.70 0.000
CLTC   Q00610 Clathrin heavy chain 1  41.3 15.5 20 -0.60 0.023 -2.23 0.000 -2.62 0.000
APOE   P02649 Apolipoprotein E  40.1 68.4 25 0.13 0.438 -0.72 0.064 -0.94 0.037
EPB41 P11171-2 Isoform 2 of Protein 4.1  39.8 30.6 21 0.98 0.007 -2.48 0.001 -0.60 0.156
KRT10   P13645 Keratin, type I cytoskeletal 10  39.7 48.5 41 -1.30 0.000 -2.42 0.000 -1.53 0.000
APOA1   P02647 Apolipoprotein A-I  39.2 56.9 23 -0.80 0.342 -1.40 0.017 0.96 0.005
KRT9   P35527 Keratin, type I cytoskeletal 9  39.0 50.2 42 -3.31 0.000 -3.31 0.000 -2.03 0.000
ATP5B   P06576 ATP synthase subunit beta, mitochondrial  38.6 35.7 20 -0.77 0.117 -2.14 0.000 -1.89 0.000
TUBA4A   P68366 Tubulin alpha-4A chain  37.5 55.1 29 -0.93 0.151 -2.94 0.012 -3.83 0.010
MMRN1   Q13201 Multimerin-1  36.6 17.6 22 -0.81 0.000 -3.10 0.000 -2.46 0.000
ITIH4   Q14624 Inter-alpha-trypsin inhibitor heavy chain H4  36.3 22.5 17 1.02 0.003 1.33 0.001 0.60 0.021
LGALS3BP   Q08380 Galectin-3-binding protein  35.9 34.4 23 -1.12 0.001 1.10 0.001 2.03 0.000
HBB   P68871 Hemoglobin subunit beta  34.8 95.2 41 1.29 0.021 2.70 0.001 2.58 0.001
PKM   P14618 Pyruvate kinase PKM  33.7 41.0 18 -1.82 0.000 -2.63 0.000 -2.23 0.000
KRT14   P02533 Keratin, type I cytoskeletal 14  33.7 60.6 49 -4.93 0.012 -5.90 0.000 -4.65 0.001
ITGB3   P05106 Integrin beta-3  32.8 22.8 21 -0.56 0.002 -2.26 0.000 -2.13 0.000
GSN   P06396 Gelsolin  32.3 22.4 19 -0.78 0.000 -2.74 0.000 -2.27 0.000
TUBB1   Q9H4B7 Tubulin beta-1 chain  31.0 60.5 32 -1.34 0.000 -3.81 0.000 -2.78 0.000
IGHV3-7   P01780 Immunoglobulin heavy variable 3-7  30.5 64.1 58 0.15 0.790 0.33 0.551 1.02 0.149
MSN   P26038 Moesin  29.6 28.4 17 -0.17 0.353 -1.73 0.043 -0.44 0.269
EPB42   P16452 Erythrocyte membrane protein band 4.2  29.5 19.0 16 0.96 0.000 -1.53 0.000 -0.72 0.132
C4BPA   P04003 C4b-binding protein alpha chain  28.1 28.3 19 -0.23 0.315 1.22 0.000 1.42 0.000
KRT2   P35908 Keratin, type II cytoskeletal 2 epidermal  28.1 41.0 30 -0.32 0.782 -1.01 0.125 -0.58 0.348
GP5   P40197 Platelet glycoprotein V  27.7 33.6 17 -0.45 0.078 -2.15 0.000 -1.90 0.000
CFH   P08603 Complement factor H  27.4 14.0 14 0.33 0.184 -0.90 0.061 0.19 0.575
STOM   P27105 Erythrocyte band 7 integral membrane protein  27.0 50.0 20 -0.07 0.592 -0.82 0.008 -1.34 0.002
GC   D6RF35 Vitamin D-binding protein  26.5 34.0 17 -1.04 0.001 -2.59 0.000 -1.42 0.000
HSPA8   P11142 Heat shock cognate 71 kDa protein  26.5 24.2 13 -0.92 0.084 -2.95 0.004 -1.95 0.040
CD5L   O43866 CD5 antigen-like  25.6 41.2 16 -0.69 0.035 0.74 0.021 1.99 0.000
APOL1   O14791 Apolipoprotein L1  25.3 34.7 14 -1.33 0.024 0.25 0.962 1.91 0.000
GP1BA   A0A0C4DGZ8 Glycoprotein Ib (Platelet), alpha polypeptide  25.2 17.4 11 -1.04 0.002 -2.23 0.000 -2.68 0.000
HBA1   P69905 Hemoglobin subunit alpha  24.6 68.3 28 2.23 0.002 3.49 0.000 3.68 0.000
C1R   B4DPQ0 Complement C1r subcomponent  23.6 23.8 11 -1.21 0.012 -0.72 0.058 0.43 0.281
ITIH2   P19823 Inter-alpha-trypsin inhibitor heavy chain H2  23.3 15.0 12 0.72 0.051 0.12 0.872 1.18 0.002
KNG1 P01042-2 Isoform LMW of Kininogen-1  23.1 28.6 12 0.69 0.029 -1.02 0.018 0.24 0.473
ILK   Q13418 Integrin-linked protein kinase  23.0 27.4 16 -1.45 0.000 -2.42 0.000 -2.09 0.000
IGHG2   P01859 Immunoglobulin heavy constant gamma 2  22.9 39.3 57 0.23 0.719 -0.49 0.845 -0.09 0.985
GAPDH   P04406 Glyceraldehyde-3-phosphate dehydrogenase  22.8 39.1 15 -1.44 0.001 -2.14 0.000 -1.44 0.001
TTN Q8WZ42-12 Isoform 12 of Titin  22.5 0.1 3 -0.01 0.979 -0.03 0.976 -0.03 0.978
C5   P01031 Complement C5  21.9 8.7 11 0.48 0.131 0.11 0.745 0.64 0.017
IGLL5   A0A0B4J231 Immunoglobulin lambda-like polypeptide 5  21.8 41.9 35 -0.20 0.894 0.69 0.616 1.70 0.289
KRT17   Q04695 Keratin, type I cytoskeletal 17  21.3 47.9 27 -4.46 0.004 -4.27 0.000 -2.87 0.000
ITIH1   P19827 Inter-alpha-trypsin inhibitor heavy chain H1  20.7 18.2 13 0.47 0.759 0.04 0.556 1.18 0.054
IGKV3-20   P01619 Immunoglobulin kappa variable 3-20  20.4 61.2 17 -0.80 0.615 -0.03 0.970 1.30 0.334
CLU P10909-2 Isoform 2 of Clusterin  20.0 23.4 15 0.52 0.289 0.35 0.451 0.57 0.193
PON1   P27169 Serum paraoxonase/arylesterase 1  20.0 39.7 11 0.82 0.005 -0.39 0.181 -0.29 0.200
TFRC   P02786 Transferrin receptor protein 1  19.5 14.2 9 -1.77 0.002 -0.27 0.298 0.01 0.870
HPX   P02790 Hemopexin  19.3 21.9 10 0.82 0.033 -0.90 0.022 0.11 0.706
PARVB Q9HBI1-2 Isoform 2 of Beta-parvin  19.2 27.2 10 -0.93 0.048 -2.02 0.003 -2.25 0.002
ITGA6   P23229 Integrin alpha-6  19.2 10.3 11 -0.82 0.007 -0.66 0.031 -2.05 0.000
CORO1C Q9ULV4-3 Isoform 3 of Coronin-1C  19.2 24.1 9 -0.94 0.005 -3.00 0.000 -2.46 0.000
FCGBP   Q9Y6R7 IgGFc-binding protein  19.0 3.1 9 -1.37 0.038 1.37 0.017 2.48 0.000
PZP   P20742 Pregnancy zone protein  18.6 16.8 126 -1.04 0.067 0.01 0.753 1.53 0.003
RSU1   Q15404 Ras suppressor protein 1  18.6 45.5 9 -1.78 0.001 -1.69 0.001 -1.83 0.001
F13A1   P00488 Coagulation factor XIII A chain  18.5 14.5 13 -0.82 0.029 -2.80 0.000 -2.55 0.000
ATP5A1   P25705 ATP synthase subunit alpha, mitochondrial  18.3 21.2 9 -0.31 0.102 -1.81 0.005 -1.90 0.018
HSPD1   P10809 60 kDa heat shock protein, mitochondrial  18.1 19.0 8 -0.98 0.022 -2.47 0.000 -2.01 0.001
ITGB1   P05556 Integrin beta-1  18.1 13.3 10 -0.85 0.020 -1.37 0.002 -1.10 0.014
ATP2A3 Q93084-5 Isoform SERCA3E of Sarcoplasmic/endoplasmic reticulum calcium ATPase 3  17.9 10.6 10 -0.78 0.067 -2.71 0.001 -3.51 0.000
RASA3   Q14644 Ras GTPase-activating protein 3  17.9 11.3 8 -0.64 0.056 -1.77 0.005 -1.86 0.017
INF2   Q27J81 Inverted formin-2  17.8 9.9 8 -0.94 0.051 -4.62 0.000 -2.39 0.003
IDH2   P48735 Isocitrate dehydrogenase [NADP], mitochondrial  17.8 20.6 8 -1.04 0.002 -3.06 0.000 -2.44 0.000
CD36   E7EU05 Platelet glycoprotein 4 (Fragment)  17.6 16.9 9 -0.61 0.027 -1.45 0.003 -1.54 0.004
CAT   P04040 Catalase  17.6 22.8 8 0.61 0.046 -0.23 0.886 0.16 0.671
VTN   P04004 Vitronectin  17.5 20.9 13 -0.23 0.265 -1.82 0.003 -0.78 0.195
PDIA3   P30101 Protein disulfide-isomerase A3  17.3 18.8 8 -0.94 0.004 -3.22 0.000 -2.58 0.000
KRT5   P13647 Keratin, type II cytoskeletal 5  17.0 30.2 31 -5.45 0.001 -5.33 0.000 -3.73 0.000
CAVIN2   O95810 Caveolae-associated protein 2  16.9 28.5 9 -0.98 0.041 -3.65 0.000 -2.26 0.004
ITGA2   P17301 Integrin alpha-2  16.6 8.4 8 -1.12 0.010 -2.02 0.002 -2.05 0.001
CAP1   Q01518 Adenylyl cyclase-associated protein 1  16.5 20.2 8 -1.29 0.049 -2.82 0.002 -2.91 0.006
  B4E1Z4 cDNA FLJ55673, highly similar to Complement factor B (EC 3.4.21.47) 16.2 6.9 8 0.65 0.038 -0.65 0.087 0.35 0.242
HSPA5   P11021 78 kDa glucose-regulated protein  15.9 16.7 8 -0.77 0.034 -3.34 0.000 -2.58 0.000
IGHV5-51   A0A0C4DH38 Immunoglobulin heavy variable 5-51  15.7 58.1 14 -1.02 0.406 -0.19 0.848 1.24 0.155
HRG   P04196 Histidine-rich glycoprotein  15.2 17.3 12 0.24 0.623 -0.61 0.144 0.56 0.183
CALD1 Q05682-5 Isoform 5 of Caldesmon  15.1 19.2 6 -0.93 0.335 -2.88 0.104 -2.64 0.121
VASP   P50552 Vasodilator-stimulated phosphoprotein  15.0 19.7 7 -0.64 0.378 -3.36 0.002 -1.42 0.024
APOH   P02749 Beta-2-glycoprotein 1  14.5 28.1 12 -0.27 0.367 -2.76 0.002 -1.75 0.007
ZYX   Q15942 Zyxin  14.3 17.3 8 -1.30 0.008 -2.52 0.001 -2.54 0.001
SERPING1 P05155-3 Isoform 3 of Plasma protease C1 inhibitor  14.3 14.5 7 0.66 0.173 -0.39 0.436 0.17 0.736
FLOT2   E7EMK3 Flotillin-2  14.2 18.0 7 -0.35 0.373 -1.54 0.007 -0.62 0.111
MASP1 P48740-2 Isoform 2 of Mannan-binding lectin serine protease 1  14.0 10.8 7 0.05 0.935 1.29 0.360 0.89 0.499
SERPINA3   P01011 Alpha-1-antichymotrypsin  13.8 17.0 8 0.05 0.978 -0.86 0.159 -0.28 0.605
MDH2   P40926 Malate dehydrogenase, mitochondrial  13.5 27.5 7 0.88 0.774 -0.73 0.141 -3.93 0.061
ADD1 P35611-3 Isoform 3 of Alpha-adducin  13.4 9.8 6 0.39 0.141 -1.85 0.036 0.00 0.716
PFN1   P07737 Profilin-1  13.4 50.7 9 -1.32 0.066 -1.70 0.005 -1.61 0.006
LTBP1 Q14766-4 Isoform 4 of Latent-transforming growth factor beta-binding protein 1  13.4 5.0 6 -1.10 0.010 -3.03 0.000 -2.19 0.001
HSP90B1   P14625 Endoplasmin  13.4 9.2 6 -0.68 0.099 -2.68 0.001 -1.59 0.004
JCHAIN   P01591 Immunoglobulin J chain  13.3 31.5 13 -0.50 0.558 0.24 0.683 2.11 0.053
ENO1   P06733 Alpha-enolase  13.2 19.6 9 -0.81 0.308 -1.46 0.042 -1.75 0.031
STXBP2 Q15833-3 Isoform 3 of Syntaxin-binding protein 2  12.9 13.1 5 -1.37 0.105 -1.00 0.160 -1.44 0.075
PRDX2   P32119 Peroxiredoxin-2  12.7 29.8 6 0.36 0.479 -0.86 0.263 0.72 0.131
AHNAK   Q09666 Neuroblast differentiation-associated protein AHNAK  12.7 2.9 5 -1.86 0.083 -2.88 0.043 -1.70 0.079
HLA-A   P01891 HLA class I histocompatibility antigen, A-68 alpha chain  12.4 20.3 5 -0.97 0.355 -1.08 0.336 -1.22 0.304
HPR   A0A0A0MRD9 Haptoglobin-related protein  12.3 55.5 39 -2.50 0.283 1.04 0.167 2.50 0.040
YWHAZ   E7EX29 14-3-3 protein zeta/delta (Fragment)  12.3 29.3 7 -1.44 0.104 -2.13 0.071 -2.46 0.060
FCN2   Q15485 Ficolin-2  12.2 29.7 10 0.27 0.718 1.58 0.075 0.64 0.325
TPM3 P06753-2 Isoform 2 of Tropomyosin alpha-3 chain  12.2 26.2 6 -1.06 0.349 -2.33 0.203 -1.97 0.226
CAPZA1   P52907 F-actin-capping protein subunit alpha-1  12.1 25.9 6 -0.82 0.197 -3.45 0.033 -3.18 0.032
PLEK   P08567 Pleckstrin  12.0 23.7 6 -0.96 0.120 -1.86 0.025 -1.87 0.022
JUP   P14923 Junction plakoglobin  12.0 7.2 5 -4.08 0.000 -4.31 0.000 -3.72 0.000
PROS1   P07225 Vitamin K-dependent protein S  11.9 10.8 6 -0.13 0.375 1.16 0.029 1.24 0.027
GANAB   Q14697 Neutral alpha-glucosidase AB  11.7 9.7 6 -0.53 0.162 -1.25 0.012 -1.50 0.005
PECAM1 P16284-6 Isoform Delta15 of Platelet endothelial cell adhesion molecule  11.6 10.0 5 -0.45 0.387 -1.21 0.035 -1.61 0.019
HSD17B4   P51659 Peroxisomal multifunctional enzyme type 2  11.6 10.3 6 -0.76 0.111 -2.39 0.005 -2.23 0.009
A1BG   P04217 Alpha-1B-glycoprotein  11.4 13.5 5 0.73 0.224 -0.97 0.169 0.17 0.724
NNT   Q13423 NAD(P) transhydrogenase, mitochondrial  11.4 5.0 5 -0.69 0.176 -1.89 0.108 -2.92 0.025
PIGR   P01833 Polymeric immunoglobulin receptor  11.3 10.9 6 -0.88 0.482 1.14 0.062 1.70 0.026
PLG   P00747 Plasminogen  11.2 8.3 6 0.21 0.714 -1.44 0.145 -0.49 0.444
IGHV3-15   A0A0B4J1V0 Immunoglobulin heavy variable 3-15  11.0 48.7 14 -0.72 0.500 -0.04 0.735 1.59 0.085
ACTR3   P61158 Actin-related protein 3  10.9 17.0 5 -0.66 0.087 -2.02 0.028 -1.55 0.035
IQGAP2   Q13576 Ras GTPase-activating-like protein IQGAP2  10.9 1.8 3 0.25 0.051 -1.10 0.002 -2.02 0.001
DIAPH1   A0A0G2JH68 Protein diaphanous homolog 1  10.9 5.0 5 -0.33 0.294 -2.10 0.001 -1.74 0.003
RAP1B   P61224 Ras-related protein Rap-1b  10.9 25.5 5 -1.20 0.043 -1.18 0.071 -1.25 0.045
SLC2A1   P11166 Solute carrier family 2, facilitated glucose transporter member 1  10.6 13.2 6 1.04 0.079 -2.75 0.010 -1.00 0.128
C1QA   P02745 Complement C1q subcomponent subunit A  10.6 16.3 6 1.02 0.349 0.13 0.594 0.35 0.639
SYNE1   Q8NF91 Nesprin-1  10.6 0.3 2 0.04 0.739 0.07 0.705 0.01 0.925
ADD2   P35612 Beta-adducin  10.5 12.1 6 1.22 0.139 -2.51 0.115 -0.32 0.711
C1QB   D6R934 Complement C1q subcomponent subunit B  10.4 23.5 10 0.41 0.133 -0.58 0.347 0.09 0.771
DNM1L   O00429 Dynamin-1-like protein  10.1 6.8 4 -0.74 0.069 -2.38 0.001 -2.62 0.045
EHD1   A0A024R571 EH domain-containing protein 1  10.1 5.7 4 -0.80 0.347 -1.83 0.009 -2.11 0.014
APOA4   P06727 Apolipoprotein A-IV  10.1 13.6 5 0.08 0.926 -0.23 0.487 0.05 0.825
TUBA1C   A0A1W2PQM2 Tubulin alpha-1C chain  10.1 45.5 15 -0.60 0.487 -2.11 0.168 -1.82 0.193
C1QC   P02747 Complement C1q subcomponent subunit C  10.0 22.0 5 0.45 0.373 -0.80 0.379 0.19 0.760
PTPRJ   A0A087WVC6 Receptor-type tyrosine-protein phosphatase eta  10.0 3.7 5 -0.85 0.165 -1.08 0.051 -0.73 0.107
IGHV4-61   A0A0C4DH41 Immunoglobulin heavy variable 4-61  10.0 38.1 7 0.01 0.763 0.64 0.262 1.57 0.073
DSP   P15924 Desmoplakin  9.8 0.9 2 -2.26 0.068 -3.04 0.107 -2.19 0.058
UNC13D   Q70J99 Protein unc-13 homolog D  9.7 6.4 4 -1.05 0.426 -2.05 0.337 -1.91 0.248
MACF1   H3BQK9 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5  9.6 0.4 2 0.11 0.498 0.05 0.965 0.12 0.389
LBP   P18428 Lipopolysaccharide-binding protein  9.5 8.7 4 1.05 0.056 -0.03 0.702 -0.01 0.669
IGHV3-9   P01782 Immunoglobulin heavy variable 3-9  9.4 55.1 19 0.41 0.436 0.15 0.698 0.33 0.501
PDIA6 Q15084-2 Isoform 2 of Protein disulfide-isomerase A6  9.3 14.4 5 -0.56 0.992 -2.03 0.171 -2.17 0.275
SACM1L   Q9NTJ5 Phosphatidylinositide phosphatase SAC1  9.1 8.7 4 -0.62 0.089 -3.51 0.000 -2.26 0.002
ESYT1 Q9BSJ8-2 Isoform 2 of Extended synaptotagmin-1  9.0 4.4 4 -1.32 0.241 -2.63 0.019 -2.82 0.020
GAPDHS   O14556 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific  9.0 13.2 13 0.09 0.877 0.11 0.822 0.08 0.977
KRT6A   P02538 Keratin, type II cytoskeletal 6A  8.7 55.0 57 -3.43 0.011 -4.04 0.008 -2.68 0.021
KIF2A O00139-4 Isoform 4 of Kinesin-like protein KIF2A  8.4 6.5 4 -0.53 0.197 -1.99 0.017 -1.38 0.050
PGK1   P00558 Phosphoglycerate kinase 1  8.4 13.4 4 -1.42 0.271 -2.34 0.189 -1.94 0.225
VDAC3   Q9Y277 Voltage-dependent anion-selective channel protein 3  8.4 15.5 3 -0.53 0.231 -1.26 0.055 -1.06 0.076
KLKB1   H0YAC1 Plasma kallikrein (Fragment)  8.4 6.7 4 -0.58 0.258 -0.50 0.543 1.09 0.043
CANX P27824-2 Isoform 2 of Calnexin  8.3 8.0 4 -0.44 0.192 -2.39 0.016 -2.03 0.127
F2   P00734 Prothrombin  8.3 7.9 4 0.97 0.072 -0.52 0.941 -0.13 0.839
IGKV4-1   P06312 Immunoglobulin kappa variable 4-1  8.3 44.6 8 -0.31 0.947 0.57 0.385 1.32 0.150
WDR1   O75083 WD repeat-containing protein 1  8.2 9.9 4 -1.06 0.099 -1.22 0.074 -1.38 0.075
IGKV2-30   P06310 Immunoglobulin kappa variable 2-30  8.1 44.2 10 -0.60 0.488 -0.13 0.874 1.02 0.317
C9   P02748 Complement component C9  8.1 7.7 4 0.15 0.732 0.07 0.958 -0.13 0.913
LRBA   P50851 Lipopolysaccharide-responsive and beige-like anchor protein  8.1 1.5 3 -0.81 0.398 -2.42 0.089 -0.96 0.305
AMBP   P02760 Protein AMBP  8.1 13.1 4 0.85 0.326 -0.12 0.808 0.93 0.205
IGHV1-18   A0A0C4DH31 Immunoglobulin heavy variable 1-18  8.0 40.2 7 0.07 0.843 0.27 0.681 0.80 0.280
BIN2   A0A0A0MT10 Bridging integrator 2 (Fragment)  8.0 10.7 4 -0.32 0.401 -1.47 0.051 -1.20 0.073
IGLV1-51   P01701 Immunoglobulin lambda variable 1-51  8.0 28.2 4 -1.38 0.368 -0.98 0.476 1.04 0.357
MYLK Q15746-5 Isoform 4 of Myosin light chain kinase, smooth muscle  8.0 2.2 4 -0.47 0.413 -1.67 0.021 -1.77 0.027
IGLV3-10   A0A075B6K4 Immunoglobulin lambda variable 3-10  8.0 33.0 4 -0.57 0.546 -0.41 0.635 0.73 0.423
MYL12B   O14950 Myosin regulatory light chain 12B  8.0 23.8 4 -1.28 0.135 -2.79 0.044 -1.75 0.081
PDLIM1   O00151 PDZ and LIM domain protein 1  8.0 17.0 4 -2.42 0.062 -2.51 0.037 -2.68 0.033
ITGAM   P11215 Integrin alpha-M  8.0 4.1 4 -0.28 0.798 -0.50 0.539 0.90 0.197
GP1BB P13224-2 Isoform 2 of Platelet glycoprotein Ib beta chain  7.9 7.8 4 -1.50 0.097 -2.84 0.050 -2.15 0.048
HK1   P19367 Hexokinase-1  7.9 3.8 3 -0.57 0.623 -0.90 0.490 0.01 0.934
ALDOA P04075-2 Isoform 2 of Fructose-bisphosphate aldolase A  7.9 7.2 3 -1.28 0.045 -2.92 0.008 -2.68 0.012
IGHA2   P01877 Immunoglobulin heavy constant alpha 2  7.8 46.5 25 -0.23 0.770 -0.98 0.336 0.44 0.566
TBXAS1   A0A0C4DH47 Thromboxane-A synthase  7.8 5.7 3 -0.76 0.254 -2.22 0.053 -2.72 0.026
TUBA8   C9J2C0 Tubulin alpha chain (Fragment)  7.8 40.3 21 -0.96 0.383 -1.25 0.314 -1.86 0.264
IGHG3   P01860 Immunoglobulin heavy constant gamma 3  7.7 51.2 67 0.86 0.405 -0.68 0.200 0.35 0.741
RAB27B   O00194 Ras-related protein Rab-27B  7.6 18.4 5 -0.56 0.512 -1.71 0.220 -1.69 0.259
SERPINC1   P01008 Antithrombin-III  7.6 9.5 4 0.41 0.462 -0.72 0.253 -0.15 0.839
PTPRC   A0A0A0MT22 Protein tyrosine phosphatase, receptor type, C, isoform CRA_d  7.5 3.4 4 -0.31 0.967 -1.24 0.243 -0.45 0.692
PTGS1 P23219-5 Isoform 5 of Prostaglandin G/H synthase 1  7.4 7.5 4 -1.17 0.103 -2.21 0.397 -2.88 0.333
SPTBN1   A0A087WUZ3 Spectrin beta chain  7.4 1.1 2 -0.32 0.541 -1.75 0.079 -0.40 0.285
UBA52   P62987 Ubiquitin-60S ribosomal protein L40  7.4 29.7 3 -0.36 0.359 -1.54 0.036 -0.53 0.258
BCHE   P06276 Cholinesterase  7.2 7.0 3 -0.12 0.365 2.18 0.014 2.39 0.008
AP2B1 P63010-2 Isoform 2 of AP-2 complex subunit beta  7.1 2.7 3 -0.57 0.230 -2.13 0.016 -1.01 0.140
P4HB   P07237 Protein disulfide-isomerase  7.0 10.0 3 -0.60 0.328 -2.51 0.038 -2.17 0.048
CROCC   Q5TZA2 Rootletin  6.9 0.6 1 0.16 0.438 -0.03 0.920 0.03 0.789
HIST1H4A   P62805 Histone H4  6.9 26.2 3 -2.51 0.020 -1.71 0.045 -1.24 0.077
DYNC1H1   Q14204 Cytoplasmic dynein 1 heavy chain 1  6.9 0.4 2 -0.40 0.312 -0.98 0.050 -1.04 0.023
F11R   Q9Y624 Junctional adhesion molecule A  6.8 8.7 4 -0.35 0.396 -2.19 0.062 -1.59 0.109
IGFALS P35858-2 Isoform 2 of Insulin-like growth factor-binding protein complex acid labile subunit  6.6 7.9 3 -0.01 0.798 -0.57 0.436 -0.25 0.807
HUWE1 Q7Z6Z7-2 Isoform 2 of E3 ubiquitin-protein ligase HUWE1  6.6 0.4 2 0.48 0.501 0.37 0.582 0.11 0.979
MYH14 Q7Z406-2 Isoform 2 of Myosin-14  6.5 3.3 12 0.35 0.644 -0.50 0.547 0.11 0.868
PF4   P02776 Platelet factor 4  6.4 39.6 3 -1.04 0.473 -2.80 0.217 -1.94 0.289
IGKV3-15   P01624 Immunoglobulin kappa variable 3-15  6.4 41.7 14 -0.62 0.764 0.13 0.648 1.28 0.298
FLOT1   O75955 Flotillin-1  6.4 10.3 4 0.08 0.759 -1.62 0.073 -0.31 0.868
IGHG4   P01861 Immunoglobulin heavy constant gamma 4  6.3 46.8 85 1.44 0.336 0.44 0.708 1.41 0.413
AP2A1   O95782 AP-2 complex subunit alpha-1  6.3 2.9 3 0.11 0.992 -1.49 0.382 -1.16 0.453
ANXA2 P07355-2 Isoform 2 of Annexin A2  6.3 11.5 3 -0.66 0.086 -0.64 0.077 -0.57 0.088
PFKP   Q01813 ATP-dependent 6-phosphofructokinase, platelet type  6.3 4.5 2 -0.13 0.554 -0.60 0.165 -0.41 0.477
ROCK2   O75116 Rho-associated protein kinase 2  6.2 2.1 2 -1.89 0.156 -1.93 0.093 -2.78 0.018
IGKV1D-16   P01601 Immunoglobulin kappa variable 1D-16 (Fragment)  6.2 39.3 6 -0.47 0.568 -0.17 0.822 0.01 0.963
SPTBN4   Q9H254 Spectrin beta chain, non-erythrocytic 4  6.1 0.8 2 0.35 0.633 0.13 0.851 -0.03 0.997
RPN1   P04843 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1  6.1 8.6 3 -0.65 0.256 -2.15 0.025 -1.55 0.032
CCT3   P49368 T-complex protein 1 subunit gamma  6.1 8.8 3 -0.39 0.505 -1.25 0.193 -1.04 0.337
CFL1   E9PK25 Cofilin-1  6.1 18.1 3 -0.62 0.532 -0.89 0.435 -1.06 0.385
CTTN   Q14247 Src substrate cortactin  6.1 5.5 3 -0.68 0.194 -2.39 0.021 -2.68 0.018
GNAQ   P50148 Guanine nucleotide-binding protein G(q) subunit alpha  6.1 10.6 3 -0.25 0.548 -0.96 0.103 -1.08 0.082
SRC P12931-2 Isoform 2 of Proto-oncogene tyrosine-protein kinase Src  6.1 7.4 3 -0.11 0.622 -0.43 0.107 -0.32 0.208
HSPB1   P04792 Heat shock protein beta-1  6.1 21.0 3 -1.86 0.060 -1.82 0.066 -1.70 0.058
CYFIP1   Q7L576 Cytoplasmic FMR1-interacting protein 1  6.1 2.9 3 -0.88 0.251 -1.02 0.217 -0.90 0.250
HLA-B   P03989 HLA class I histocompatibility antigen, B-27 alpha chain  6.1 16.3 4 -1.16 0.109 -1.44 0.108 -1.16 0.165
APCS   P02743 Serum amyloid P-component  6.1 14.8 3 1.98 0.050 -0.45 0.563 0.44 0.473
DBN1 Q16643-2 Isoform 2 of Drebrin  6.0 6.5 3 -1.08 0.188 -2.15 0.072 -1.28 0.145
FHOD1   Q9Y613 FH1/FH2 domain-containing protein 1  6.0 3.4 3 -0.85 0.224 -3.85 0.030 -2.38 0.093
RAB11B Q15907-2 Isoform 2 of Ras-related protein Rab-11B  6.0 20.1 3 -0.82 0.402 -1.85 0.214 -1.51 0.253
IGKV1-9   A0A0C4DH69 Immunoglobulin kappa variable 1-9  6.0 29.1 8 0.05 0.923 -0.49 0.551 -0.27 0.738
ANXA1   P04083 Annexin A1  6.0 7.5 2 -1.45 0.139 -2.07 0.105 -0.68 0.990
PRKAR1A   P10644 cAMP-dependent protein kinase type I-alpha regulatory subunit  6.0 12.3 3 -0.49 0.632 -1.94 0.271 -1.18 0.631
S100A9   P06702 Protein S100-A9  6.0 34.2 3 -1.91 0.081 -1.93 0.082 -1.61 0.127
ARPC4 P59998-3 Isoform 3 of Actin-related protein 2/3 complex subunit 4  5.9 8.6 2 -0.76 0.299 -1.90 0.073 -1.83 0.083
MYH10 P35580-3 Isoform 3 of Myosin-10  5.9 7.2 26 -0.03 0.984 -0.47 0.571 -0.09 0.909
ARHGAP6   O43182 Rho GTPase-activating protein 6  5.9 3.7 3 -0.58 0.458 -1.09 0.485 -0.66 0.492
GSR   P00390 Glutathione reductase, mitochondrial  5.8 4.4 2 -0.65 0.690 -0.94 0.909 -1.37 0.278
C4B_2   A0A0G2JL54 Complement C4-B  5.7 39.8 87 -2.75 0.899 0.81 0.305 0.33 0.366
PCBP1   Q15365 Poly(rC)-binding protein 1  5.7 9.8 3 -0.92 0.125 -3.43 0.010 -1.66 0.153
MPP1 Q00013-3 Isoform 3 of 55 kDa erythrocyte membrane protein  5.6 8.3 3 0.31 0.599 -1.37 0.117 -0.93 0.209
EPPK1   A0A087X1U6 Epiplakin  5.5 1.2 3 0.12 0.859 0.24 0.737 0.49 0.539
RAB10   P61026 Ras-related protein Rab-10  5.5 17.0 3 -1.02 0.450 -2.25 0.228 -2.42 0.237
LDHB   P07195 L-lactate dehydrogenase B chain  5.3 5.4 2 -1.38 0.139 -2.01 0.083 -0.92 0.218
AFM   P43652 Afamin  5.3 5.0 3 0.62 0.348 -1.20 0.180 -0.21 0.908
GNB4   Q9HAV0 Guanine nucleotide-binding protein subunit beta-4  5.3 7.1 2 -0.19 0.731 -0.81 0.280 -0.45 0.464
GDI2   P50395 Rab GDP dissociation inhibitor beta  5.2 4.7 2 -1.50 0.260 -1.28 0.279 -1.32 0.337
HADHA   P40939 Trifunctional enzyme subunit alpha, mitochondrial  5.2 5.4 3 -0.92 0.206 -2.22 0.069 -2.47 0.044
IGLC7   A0M8Q6 Immunoglobulin lambda constant 7  5.2 60.4 25 0.37 0.622 0.78 0.392 1.00 0.323
ACLY   P53396 ATP-citrate synthase  5.2 1.4 1 -0.15 0.733 -0.93 0.141 -0.90 0.180
SERPIND1   P05546 Heparin cofactor 2  5.2 4.6 3 1.09 0.113 -0.53 0.792 0.08 0.924
CSE1L   P55060 Exportin-2  5.1 2.7 2 -0.09 0.794 -0.54 0.126 -0.49 0.153
GP9   P14770 Platelet glycoprotein IX  4.9 15.8 2 -1.20 0.424 -1.49 0.363 -1.40 0.376
IGKV1-5   P01602 Immunoglobulin kappa variable 1-5  4.8 24.8 3 -0.24 0.782 -0.12 0.905 0.20 0.665
EEF1A2   Q05639 Elongation factor 1-alpha 2  4.8 6.0 3 -1.34 0.345 -2.48 0.242 -1.51 0.311
MYL6   B7Z6Z4 Myosin light polypeptide 6  4.8 12.2 4 -1.36 0.097 -3.00 0.039 -3.43 0.038
CYB5R3 P00387-3 Isoform 3 of NADH-cytochrome b5 reductase 3  4.7 9.0 3 -0.65 0.463 -1.33 0.258 -1.10 0.304
HAO2 Q9NYQ3-2 Isoform 2 of Hydroxyacid oxidase 2  4.7 3.6 3 0.01 0.958 0.15 0.771 0.09 0.917
MTHFD1   P11586 C-1-tetrahydrofolate synthase, cytoplasmic  4.7 2.5 2 -0.35 0.570 -0.76 0.344 -1.00 0.193
GNAS   Q5JWF2 Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas  4.7 2.6 2 -0.01 0.929 -0.70 0.443 -0.13 0.871
CLIC1   O00299 Chloride intracellular channel protein 1  4.6 11.2 2 -0.74 0.206 -1.24 0.121 -0.98 0.215
FLII   Q13045 Protein flightless-1 homolog  4.6 1.9 2 -0.58 0.339 -2.11 0.040 -2.86 0.029
TOR4A   Q9NXH8 Torsin-4A  4.6 5.4 2 -1.32 0.331 -3.04 0.189 -3.04 0.167
DAAM1   Q9Y4D1 Disheveled-associated activator of morphogenesis 1  4.6 2.4 2 -0.49 0.402 -1.98 0.091 -2.03 0.086
TUBB4B   P68371 Tubulin beta-4B chain  4.6 44.7 29 -0.40 0.662 -0.61 0.477 -0.45 0.553
CS   O75390 Citrate synthase, mitochondrial  4.6 4.5 2 -0.89 0.190 -1.98 0.049 -1.69 0.063
GPX1   A0A087WUQ6 Glutathione peroxidase  4.6 13.4 2 -0.64 0.281 -1.54 0.071 -1.89 0.050
SAA2-SAA4   A0A096LPE2 SAA2-SAA4 readthrough  4.6 11.5 2 0.72 0.446 0.24 0.913 1.10 0.290
AK2   G3V213 Adenylate kinase 2, isoform CRA_a  4.5 7.5 2 -0.39 0.626 -0.53 0.531 -1.08 0.311
TPM4   P67936 Tropomyosin alpha-4 chain  4.5 21.0 5 -1.08 0.310 -1.45 0.239 -1.00 0.331
YWHAH   Q04917 14-3-3 protein eta  4.5 12.2 3 -0.66 0.494 -1.44 0.270 -1.83 0.219
SLC2A14   Q8TDB8 Solute carrier family 2, facilitated glucose transporter member 14  4.5 6.7 4 -0.93 0.313 -1.18 0.248 -1.40 0.210
UGGT1   Q9NYU2 UDP-glucose:glycoprotein glucosyltransferase 1  4.5 1.5 2 -0.29 0.647 -0.98 0.263 -0.84 0.301
CAPZB   B1AK88 Capping protein (Actin filament) muscle Z-line, beta, isoform CRA_d  4.4 8.6 2 -1.12 0.406 -2.11 0.219 -1.99 0.220
HSPA9   P38646 Stress-70 protein, mitochondrial  4.4 4.6 2 -0.64 0.465 -1.34 0.252 -1.08 0.315
STIM1   G0XQ39 STIM1L  4.4 3.2 2 -0.37 0.623 -3.56 0.185 -3.34 0.165
CENPF   P49454 Centromere protein F  4.4 0.3 1 0.03 0.938 0.24 0.731 -0.05 0.973
HIST1H3D   A0A0U1RRH7 Histone H2A  4.3 16.5 2 -1.61 0.236 -0.81 0.437 -0.74 0.522
ARHGAP45 Q92619-2 Isoform 2 of Rho GTPase-activating protein 45  4.3 3.6 2 -0.17 0.758 -1.13 0.282 -0.77 0.423
SEPT7 E7EPK1 Septin-7  4.3 5.3 2 -0.69 0.569 -1.49 0.314 -1.46 0.303
SERPINA5   P05154 Plasma serine protease inhibitor  4.3 5.2 2 -0.35 0.570 0.64 0.449 -0.28 0.477
COPA   P53621 Coatomer subunit alpha  4.2 1.6 2 -0.29 0.662 -1.30 0.201 -1.02 0.259
FLNC   Q14315 Filamin-C  4.2 4.7 14 -0.08 0.925 0.07 0.907 0.17 0.798
IGHV3OR15-7   A0A075B7D8 Immunoglobulin heavy variable 3/OR15-7 (pseudogene) (Fragment)  4.2 42.9 42 0.29 0.691 0.68 0.437 1.74 0.198
STK24 Q9Y6E0-2 Isoform A of Serine/threonine-protein kinase 24  4.2 3.2 2 -0.54 0.534 -1.46 0.280 -1.59 0.266
ITGB2   P05107 Integrin beta-2  4.2 3.6 2 0.09 0.660 0.09 0.685 0.17 0.522
PANK4   E9PHT6 Pantothenate kinase 4 (Fragment)  4.2 3.7 2 0.08 0.896 0.19 0.778 0.29 0.688
UBE2O   Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme  4.2 1.9 2 -0.41 0.478 -0.28 0.627 -0.21 0.705
SKAP2   O75563 Src kinase-associated phosphoprotein 2  4.2 5.0 2 -0.69 0.417 -1.44 0.230 -1.77 0.176
APOD   C9JF17 Apolipoprotein D (Fragment)  4.2 10.2 3 0.08 0.559 -0.09 0.678 -0.19 0.375
ATP1A3   A0A0A0MT26 Sodium/potassium-transporting ATPase subunit alpha-3  4.2 2.1 2 0.04 0.837 -0.57 0.415 -0.41 0.503
GFM2 Q969S9-3 Isoform 3 of Ribosome-releasing factor 2, mitochondrial  4.2 3.9 2 -0.05 0.996 -0.16 0.820 -0.28 0.704
SERPINF2   P08697 Alpha-2-antiplasmin  4.1 4.9 2 0.31 0.626 -0.80 0.300 -0.35 0.588
TLN2   Q9Y4G6 Talin-2  4.1 6.6 24 0.25 0.720 0.32 0.661 0.24 0.737
NAPRT   G5E977 Nicotinate phosphoribosyltransferase  4.1 2.1 1 -0.23 0.720 -1.38 0.234 -0.68 0.421
ORM1   P02763 Alpha-1-acid glycoprotein 1  4.1 11.9 2 0.20 0.716 -0.01 0.926 0.24 0.588
CAPZA2   P47755 F-actin-capping protein subunit alpha-2  4.1 13.6 3 -0.15 0.974 -0.48 0.477 -0.39 0.593
LIMS1 P48059-3 Isoform 3 of LIM and senescent cell antigen-like-containing domain protein 1  4.1 5.9 2 -0.93 0.421 -2.22 0.222 -1.81 0.261
DSG1   Q02413 Desmoglein-1  4.1 3.9 2 -0.57 0.472 -0.85 0.373 -0.65 0.437
STX11   O75558 Syntaxin-11  4.1 7.3 2 -1.04 0.373 -2.31 0.201 -2.03 0.213
SERPINA4   P29622 Kallistatin  4.1 5.6 2 -0.07 0.943 -0.50 0.431 -0.03 0.806
CD44   P16070 CD44 antigen  4.0 3.8 2 0.13 0.835 -0.53 0.500 -0.25 0.722
AGT   P01019 Angiotensinogen  4.0 4.1 2 0.17 0.903 -1.13 0.482 0.54 0.652
EEF1G P26641-2 Isoform 2 of Elongation factor 1-gamma  4.0 4.7 2 -0.84 0.331 -1.01 0.276 -0.65 0.410
GYPA   A0A087WU29 Glycophorin  4.0 20.9 3 1.87 0.272 -0.58 0.671 -0.41 0.706
S100A8   P05109 Protein S100-A8  4.0 23.7 2 -1.00 0.419 -1.21 0.416 -0.82 0.465
GPD2   P43304 Glycerol-3-phosphate dehydrogenase, mitochondrial  4.0 2.6 2 -0.11 0.237 0.07 0.526 0.01 0.670
TTR   P02766 Transthyretin  4.0 24.5 2 -0.20 0.832 -0.24 0.743 0.01 0.908
APOC3   B0YIW2 Apolipoprotein C-III  4.0 29.1 3 -0.25 0.666 -0.66 0.425 -0.23 0.670
C4BPB   P20851 C4b-binding protein beta chain  4.0 9.1 2 -0.28 0.785 0.74 0.501 1.08 0.371
IGHV3-49   A0A0A0MS15 Immunoglobulin heavy variable 3-49  4.0 31.9 8 1.40 0.539 1.37 0.611 1.40 0.510
IGLV1-47   P01700 Immunoglobulin lambda variable 1-47  4.0 24.8 2 -0.62 0.693 0.96 0.442 1.87 0.244
IGLV2-8   P01709 Immunoglobulin lambda variable 2-8  4.0 16.1 4 -0.47 0.572 0.04 0.943 0.97 0.330
IGLV3-19   P01714 Immunoglobulin lambda variable 3-19  4.0 24.1 2 0.01 0.975 0.12 0.898 1.59 0.254
IGLV3-21   P80748 Immunoglobulin lambda variable 3-21  4.0 29.1 2 -0.08 0.944 0.37 0.647 1.42 0.250
PPBP   P02775 Platelet basic protein  4.0 14.8 2 -1.45 0.277 -3.04 0.153 -3.06 0.152
PPIA   P62937 Peptidyl-prolyl cis-trans isomerase A  4.0 18.2 2 -1.47 0.287 -1.41 0.305 -1.58 0.291
VDAC2 P45880-1 Isoform 1 of Voltage-dependent anion-selective channel protein 2  4.0 6.5 2 -0.78 0.374 -1.65 0.186 -1.65 0.186
ARL6IP5   O75915 PRA1 family protein 3  4.0 5.9 1 -1.16 0.328 -2.59 0.171 -1.75 0.232
FASN   A0A0U1RQF0 Fatty acid synthase  3.9 0.4 1 -0.15 0.765 -0.13 0.843 -0.12 0.691
PDLIM7   Q9NR12 PDZ and LIM domain protein 7  3.9 5.0 2 -1.14 0.291 -2.47 0.141 -2.70 0.146
C8B   P07358 Complement component C8 beta chain  3.8 5.2 2 0.29 0.667 -0.17 0.995 0.03 0.990
CAPN1   P07384 Calpain-1 catalytic subunit  3.8 4.3 2 -0.49 0.433 -0.57 0.380 -0.33 0.557
ICAM2   J3QRT5 Intercellular adhesion molecule 2  3.8 9.2 2 -0.11 0.373 -0.29 0.140 -0.47 0.078
LAP3   P28838 Cytosol aminopeptidase  3.8 4.6 2 -0.11 0.891 -0.58 0.498 -0.41 0.611
TCP1   P17987 T-complex protein 1 subunit alpha  3.7 4.3 2 -0.39 0.630 -1.54 0.226 -1.28 0.268
SYNE2   A0A0A0MRE3 Nesprin-2  3.7 0.1 1 0.12 0.857 -0.16 0.843 0.62 0.463
C7   P10643 Complement component C7  3.6 1.3 2 0.58 0.521 0.05 0.967 0.73 0.328
TGFB1I1   O43294 Transforming growth factor beta-1-induced transcript 1 protein  3.5 2.0 1 -0.50 0.588 -1.65 0.321 -1.78 0.285
TJP2   Q9UDY2 Tight junction protein ZO-2  3.5 0.7 1 -1.00 0.106 -1.87 0.043 -1.94 0.046
UBR4 Q5T4S7-3 Isoform 3 of E3 ubiquitin-protein ligase UBR4  3.5 0.2 1 0.13 0.831 -0.53 0.509 -0.31 0.679
C2CD3   Q4AC94 C2 domain-containing protein 3  3.5 0.3 1 0.11 0.871 0.07 0.908 0.23 0.747
TMOD1   P28289 Tropomodulin-1  3.5 10.3 2 1.67 0.290 -0.48 0.578 0.82 0.577
IPO5   H0Y8C6 Importin-5 (Fragment)  3.5 1.5 1 -0.43 0.522 -0.33 0.514 -0.57 0.393
SEPT2 Q15019-3 Isoform 3 of Septin-2  3.5 7.5 2 -0.80 0.454 -1.90 0.240 -1.29 0.305
UBA7   P41226 Ubiquitin-like modifier-activating enzyme 7  3.4 2.9 2 -0.48 0.560 -1.02 0.326 -0.86 0.372
RAB7A   P51149 Ras-related protein Rab-7a  3.4 11.6 2 -0.69 0.516 -1.37 0.343 -1.04 0.402
APOA2   V9GYM3 Apolipoprotein A-II  3.4 8.3 2 0.19 0.788 -0.47 0.473 -0.13 0.887
HBD   P02042 Hemoglobin subunit delta  3.4 49.0 26 0.97 0.522 2.10 0.255 2.06 0.262
IGHV3-74   A0A0B4J1X5 Immunoglobulin heavy variable 3-74  3.4 64.1 51 0.05 0.889 0.50 0.859 1.99 0.296
SYTL4   Q96C24 Synaptotagmin-like protein 4  3.3 3.3 1 -1.40 0.239 -4.77 0.132 -3.22 0.203
CNN2   B4DUT8 Calponin  3.3 8.5 2 -0.04 0.965 -0.97 0.340 -0.41 0.604
DDOST   P39656 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit  3.3 2.0 1 -0.74 0.562 -2.31 0.303 -2.11 0.353
EMILIN1   A0A0C4DFX3 EMILIN-1  3.3 1.2 1 -0.39 0.466 -0.36 0.528 -0.35 0.574
PKHD1L1   Q86WI1 Fibrocystin-L  3.3 0.4 1 -0.32 0.520 0.04 0.909 0.60 0.363
SLC44A1   Q8WWI5 Choline transporter-like protein 1  3.3 2.1 1 -0.37 0.516 -0.58 0.470 -0.78 0.318
IQGAP3   Q86VI3 Ras GTPase-activating-like protein IQGAP3  3.3 0.7 1 0.70 0.423 -0.37 0.645 0.12 0.852
GPLD1   P80108 Phosphatidylinositol-glycan-specific phospholipase D  3.2 1.1 1 0.03 0.930 0.13 0.823 0.17 0.759
PEX1   O43933 Peroxisome biogenesis factor 1  3.2 1.8 3 0.01 0.994 0.17 0.746 -0.01 0.915
CPT1A   P50416 Carnitine O-palmitoyltransferase 1, liver isoform  3.2 1.0 1 0.13 0.253 -0.28 0.945 -0.11 0.345
LYN P07948-2 Isoform 2 of Tyrosine-protein kinase Lyn  3.2 4.9 2 -0.65 0.289 -1.58 0.117 -1.97 0.091
AP3B1   O00203 AP-3 complex subunit beta-1  3.2 2.3 2 0.31 0.612 -0.01 0.995 -0.05 0.782
COL6A3   P12111 Collagen alpha-3(VI) chain  3.2 0.5 1 -0.19 0.666 0.41 0.442 0.47 0.410
PCYOX1   Q9UHG3 Prenylcysteine oxidase 1  3.2 3.0 1 0.09 0.543 0.03 0.900 -0.05 0.713
SELENOP   P49908 Selenoprotein P  3.1 3.4 2 0.13 0.820 -0.65 0.466 -0.43 0.596
KMT2A   Q03164 Histone-lysine N-methyltransferase 2A  3.1 0.3 1 0.17 0.792 0.00 0.979 0.15 0.830
GMPR2   H0YNJ6 GMP reductase  3.1 2.8 1 -0.04 0.999 0.03 0.911 -0.01 0.981
NCKAP5L Q9HCH0-2 Isoform 2 of Nck-associated protein 5-like  3.1 1.1 1 0.05 0.666 0.43 0.075 0.01 0.559
ENDOD1   O94919 Endonuclease domain-containing 1 protein  3.1 2.2 1 -0.76 0.390 -1.57 0.251 -1.85 0.204
ITGAL P20701-2 Isoform 2 of Integrin alpha-L  3.1 1.6 1 -0.19 0.817 -0.58 0.496 -0.08 0.920
ECE1 P42892-2 Isoform A of Endothelin-converting enzyme 1  3.0 3.2 1 -0.09 0.835 -0.36 0.988 -0.19 0.826
GPR179   Q6PRD1 Probable G-protein coupled receptor 179  3.0 0.3 1 -0.32 0.687 -0.23 0.768 0.07 0.905
MAPKAPK5   Q8IW41 MAP kinase-activated protein kinase 5  3.0 1.5 1 0.16 0.793 0.21 0.743 0.19 0.762
CHTOP   Q9Y3Y2 Chromatin target of PRMT1 protein  2.9 6.0 1 0.09 0.862 0.12 0.854 -0.01 0.999
DOCK5   Q9H7D0 Dedicator of cytokinesis protein 5  2.9 0.4 1 -0.53 0.525 -0.93 0.353 -1.14 0.294
FYB O15117-3 Isoform 3 of FYN-binding protein  2.9 2.0 1 -0.43 0.391 -0.27 0.571 -0.43 0.406
IGHV1-3   A0A0C4DH29 Immunoglobulin heavy variable 1-3  2.9 38.5 5 -0.16 0.841 -0.53 0.507 -0.01 0.972
SORCS1   Q8WY21 VPS10 domain-containing receptor SorCS1  2.9 0.9 1 0.01 0.890 -0.17 0.805 -0.11 0.840
RAC2   B1AH80 Ras-related C3 botulinum toxin substrate 2  2.9 7.6 1 -0.98 0.520 -2.10 0.255 -0.97 0.432
UGP2   Q16851 UTP--glucose-1-phosphate uridylyltransferase  2.9 2.4 1 -1.97 0.251 -1.16 0.379 -0.86 0.458
GARS   P41250 Glycine--tRNA ligase  2.9 1.8 1 -0.86 0.372 -2.23 0.158 -1.44 0.240
ALMS1   A0A087WZY3 Alstrom syndrome protein 1  2.8 0.3 1 0.12 0.848 0.54 0.503 0.40 0.603
VIM   P08670 Vimentin  2.8 3.0 1 -0.23 0.674 -0.47 0.432 -0.70 0.289
CCT4   P50991 T-complex protein 1 subunit delta  2.8 3.0 1 0.15 0.800 -0.13 0.845 -0.24 0.721
RELN P78509-2 Isoform 2 of Reelin  2.8 0.4 2 -0.25 0.992 0.97 0.321 1.21 0.290
TMOD3   Q9NYL9 Tropomodulin-3  2.8 3.1 1 -0.82 0.385 -1.33 0.258 -1.14 0.296
IGHV6-1   A0A0B4J1U7 Immunoglobulin heavy variable 6-1  2.8 7.4 1 0.21 0.961 1.25 0.461 2.56 0.232
MLEC   Q14165 Malectin  2.7 4.8 2 -0.65 0.485 -2.71 0.176 -2.33 0.194
SHC2   K7EKS8 SHC-transforming protein 2 (Fragment)  2.7 8.7 1 0.15 0.975 0.47 0.808 0.09 0.986
APOM   Q5SRP5 Apolipoprotein M  2.7 7.0 1 2.07 0.269 1.16 0.541 1.12 0.453
LDHA P00338-3 Isoform 3 of L-lactate dehydrogenase A chain  2.6 2.2 1 -0.61 0.304 -0.66 0.280 -0.76 0.228
ERBIN Q96RT1-8 Isoform 8 of Erbin  2.6 0.5 1 -0.39 0.633 -0.73 0.426 0.28 0.695
CRTAC1 Q9NQ79-2 Isoform 2 of Cartilage acidic protein 1  2.6 1.4 1 0.60 0.473 0.53 0.510 0.07 0.909
ATAD3A   H0Y2W2 ATPase family AAA domain-containing protein 3A (Fragment)  2.6 2.1 1 0.27 0.708 0.13 0.828 0.09 0.883
  A0A1B0GU03 Uncharacterized protein 2.6 1.7 1 -0.40 0.803 -1.00 0.308 -0.84 0.455
CKAP5   Q14008 Cytoskeleton-associated protein 5  2.5 0.8 1 -0.15 0.683 -0.28 0.462 -0.08 0.850
NPHP3   Q7Z494 Nephrocystin-3  2.5 0.8 1 0.21 0.673 0.21 0.666 0.25 0.620
GNAI2 P04899-4 Isoform sGi2 of Guanine nucleotide-binding protein G(i) subunit alpha-2  2.5 7.1 2 -0.20 0.800 -0.33 0.673 -0.16 0.834
ARAP1   Q96P48 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1  2.5 0.7 1 -0.20 0.801 -1.42 0.319 -1.91 0.263
DMTN   Q08495 Dematin  2.5 2.7 2 0.11 0.844 -0.92 0.353 -0.28 0.746
UQCRC2   P22695 Cytochrome b-c1 complex subunit 2, mitochondrial  2.5 4.6 1 -0.94 0.144 -1.24 0.228 -0.92 0.386
FCN1   O00602 Ficolin-1  2.5 4.3 1 -0.12 0.867 0.05 0.924 0.96 0.318
KALRN O60229-4 Isoform 4 of Kalirin  2.4 0.8 1 -0.11 0.749 -0.17 0.436 -0.24 0.365
CTSG   P08311 Cathepsin G  2.4 3.5 1 -0.49 0.415 -0.89 0.316 0.05 0.993
LENG1   Q96BZ8 Leukocyte receptor cluster member 1  2.4 3.4 1 0.08 0.901 0.41 0.585 0.52 0.520
FBLN1   P23142 Fibulin-1  2.4 1.7 1 -0.04 0.734 -0.12 0.695 -0.25 0.624
PSMD1   A0A087WW66 26S proteasome non-ATPase regulatory subunit 1  2.4 1.3 1 0.65 0.450 0.07 0.912 0.25 0.714
CCDC57   Q2TAC2 Coiled-coil domain-containing protein 57  2.4 0.9 1 -0.48 0.563 0.35 0.638 0.53 0.510
KIF27   Q86VH2 Kinesin-like protein KIF27  2.4 0.5 1 -0.08 0.983 0.43 0.769 0.45 0.810
UBA1   P22314 Ubiquitin-like modifier-activating enzyme 1  2.4 1.0 1 -0.78 0.251 -0.89 0.213 -0.73 0.237
ACTR2 P61160-2 Isoform 2 of Actin-related protein 2  2.3 3.5 1 -0.13 0.868 -0.66 0.457 -0.43 0.596
LGALS8 O00214-2 Isoform 2 of Galectin-8  2.3 2.5 1 -0.12 0.962 0.23 0.645 0.08 0.865
AHNAK2   Q8IVF2 Protein AHNAK2  2.3 0.2 1 0.01 0.963 -0.08 0.925 -0.17 0.832
GART   P22102 Trifunctional purine biosynthetic protein adenosine-3  2.3 1.1 1 -0.01 0.918 0.01 0.989 0.09 0.865
AKT2   M0R0P9 RAC-beta serine/threonine-protein kinase  2.3 1.8 1 -0.23 0.897 -0.64 0.317 -0.45 0.480
CLCN5 P51795-2 Isoform 2 of H(+)/Cl(-) exchange transporter 5  2.3 0.9 1 -0.43 0.540 -1.57 0.219 -1.69 0.218
DACT3   Q96B18 Dapper homolog 3  2.3 1.7 1 0.07 0.904 0.62 0.460 0.57 0.488
RAB8A   P61006 Ras-related protein Rab-8A  2.3 12.1 2 -0.32 0.687 -0.43 0.594 -0.45 0.583
HIST1H2BA   Q96A08 Histone H2B type 1-A  2.3 7.1 1 -1.46 0.250 -0.77 0.424 -0.60 0.501
TBCCD1   Q9NVR7 TBCC domain-containing protein 1  2.3 1.1 1 0.08 0.986 0.50 0.675 0.44 0.697
ECH1   Q13011 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial  2.3 4.9 1 -0.57 0.498 -1.29 0.261 -0.86 0.383
ACTN4   O43707 Alpha-actinin-4  2.2 16.0 14 -1.04 0.370 -1.94 0.217 -1.93 0.229
PPIB   P23284 Peptidyl-prolyl cis-trans isomerase B  2.2 3.7 1 -0.90 0.438 -3.73 0.166 -2.76 0.248
STX16 O14662-5 Isoform E of Syntaxin-16  2.2 2.8 1 -0.65 0.462 -1.53 0.228 -1.47 0.235
COPB1   P53618 Coatomer subunit beta  2.2 1.2 1 -0.37 0.553 -1.08 0.203 -1.04 0.179
EFCC1   Q9HA90 EF-hand and coiled-coil domain-containing protein 1  2.2 2.8 1 0.28 0.700 0.61 0.466 0.88 0.359
RHAG   A0A0A0MQS8 Ammonium transporter Rh type A  2.2 2.2 1 1.49 0.250 -0.97 0.387 -0.62 0.521
BLNK   Q8WV28 B-cell linker protein  2.2 3.1 1 0.07 0.904 -0.01 0.993 0.33 0.651
KIF17 Q9P2E2-3 Isoform 2 of Kinesin-like protein KIF17  2.2 0.9 1 0.27 0.678 0.19 0.757 0.03 0.955
RP2   O75695 Protein XRP2  2.2 2.3 1 -0.68 0.674 -1.65 0.465 -1.26 0.514
AP2M1   A0A087WY71 AP-2 complex subunit mu  2.2 2.1 1 -1.38 0.382 -1.34 0.542 -0.93 0.588
MED23   Q9ULK4 Mediator of RNA polymerase II transcription subunit 23  2.2 0.6 2 0.36 0.846 0.86 0.605 0.50 0.813
NAP1L1   F8VXI6 Nucleosome assembly protein 1-like 1 (Fragment)  2.2 7.9 1 -0.48 0.560 -0.77 0.410 -0.53 0.526
LRP1   Q07954 Prolow-density lipoprotein receptor-related protein 1  2.2 0.3 1 0.16 0.826 -0.17 0.843 -0.01 0.992
NSF   I3L0N3 Vesicle-fusing ATPase  2.2 1.4 1 -0.52 0.476 -0.86 0.393 -1.05 0.315
PDCD6IP   Q8WUM4 Programmed cell death 6-interacting protein  2.2 1.5 1 -0.48 0.694 -1.63 0.414 -0.78 0.587
DPYSL2   A0A1C7CYX9 Dihydropyrimidinase-related protein 2  2.2 2.4 1 -0.17 0.819 -0.48 0.561 -0.61 0.485
OXCT1   P55809 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial  2.2 4.0 1 0.11 0.620 0.15 0.573 -0.21 0.527
RTN4   Q9NQC3 Reticulon-4  2.2 1.1 1 -0.58 0.638 -2.15 0.187 -2.10 0.184
ARHGEF2   V9GYM8 Rho guanine nucleotide exchange factor 2  2.2 1.0 1 -0.61 0.480 -0.80 0.396 -0.64 0.470
SLC25A4   P12235 ADP/ATP translocase 1  2.2 4.0 1 -0.64 0.510 -2.47 0.178 -3.36 0.142
TGFBI   Q15582 Transforming growth factor-beta-induced protein ig-h3  2.2 1.8 1 0.39 0.626 -0.17 0.751 0.49 0.553
TREML1   Q86YW5 Trem-like transcript 1 protein  2.2 6.4 1 -1.13 0.299 -1.40 0.246 -1.04 0.321
KDM5D Q9BY66-3 Isoform 3 of Lysine-specific demethylase 5D  2.1 0.5 1 -1.49 0.234 -1.13 0.298 -0.81 0.391
CYP1B1   Q16678 Cytochrome P450 1B1  2.1 1.3 1 0.07 0.847 0.33 0.644 -0.09 0.954
HEG1   Q9ULI3 Protein HEG homolog 1  2.1 0.6 1 -0.15 0.848 0.03 0.956 0.68 0.436
PDLIM5 Q96HC4-6 Isoform 6 of PDZ and LIM domain protein 5  2.1 1.4 1 -0.76 0.535 -3.00 0.212 -3.02 0.212
PSMB2   P49721 Proteasome subunit beta type-2  2.1 5.5 1 0.16 0.757 -0.88 0.449 0.13 0.839
PSMD2 Q13200-2 Isoform 2 of 26S proteasome non-ATPase regulatory subunit 2  2.1 2.0 1 -0.03 0.837 -0.40 0.600 -0.04 0.876
TGFB1   P01137 Transforming growth factor beta-1  2.1 4.9 2 -0.77 0.452 -2.70 0.169 -2.26 0.191
CCT6A   P40227 T-complex protein 1 subunit zeta  2.1 1.7 1 -0.69 0.434 -1.37 0.245 -1.24 0.276
KATNAL1   Q9BW62 Katanin p60 ATPase-containing subunit A-like 1  2.1 2.4 2 0.05 0.921 0.11 0.862 0.17 0.796
LRRC32   Q14392 Leucine-rich repeat-containing protein 32  2.1 2.1 1 -1.34 0.352 -1.30 0.341 -1.14 0.315
RAB1C   Q92928 Putative Ras-related protein Rab-1C  2.1 13.4 2 -0.20 0.792 -0.69 0.444 -0.65 0.463
ATP6V0A1   K7EN36 V-type proton ATPase subunit a (Fragment)  2.1 5.1 1 -0.92 0.360 -0.93 0.358 -0.65 0.460
FCGR3A   M9MML0 Low affinity immunoglobulin gamma Fc region receptor III-A  2.1 3.1 1 0.05 0.812 -0.92 0.225 0.45 0.300
MGLL   A0A0C4DFN3 Monoglyceride lipase  2.1 3.2 1 -0.81 0.393 -0.81 0.394 -0.48 0.562
RNH1   P13489 Ribonuclease inhibitor  2.1 2.4 1 -0.98 0.337 -1.45 0.239 -1.46 0.237
RPS16   P62249 40S ribosomal protein S16  2.1 6.8 1 0.31 0.662 0.05 0.924 -0.19 0.838
ALDH5A1   P51649 Succinate-semialdehyde dehydrogenase, mitochondrial  2.1 1.9 1 0.16 0.732 -0.07 0.811 0.11 0.859
EPB41   A0A1B0GWG0 Protein 4.1 (Fragment)  2.1 23.6 11 0.78 0.508 -1.62 0.394 -0.77 0.589
KIAA2013 Q8IYS2-2 Isoform 2 of Uncharacterized protein KIAA2013  2.1 2.1 1 0.21 0.745 0.01 0.982 -0.21 0.775
PAICS   P22234 Multifunctional protein ADE2  2.1 2.6 1 0.05 0.919 -1.02 0.325 -0.32 0.690
GNAZ   P19086 Guanine nucleotide-binding protein G(z) subunit alpha  2.1 4.2 1 -0.24 0.761 -0.19 0.808 -0.35 0.664
HADHB   P55084 Trifunctional enzyme subunit beta, mitochondrial  2.1 1.9 1 -0.07 0.947 -0.77 0.411 -0.39 0.632
PGLYRP2 Q96PD5-2 Isoform 2 of N-acetylmuramoyl-L-alanine amidase  2.1 2.2 1 0.25 0.726 -0.05 0.953 -0.05 0.956
PSMA6   G3V5Z7 Proteasome subunit alpha type  2.1 3.6 1 -0.09 0.807 -0.13 0.800 0.08 0.979
SERPINB3   P29508 Serpin B3  2.1 2.6 1 -1.01 0.407 -1.90 0.242 -1.66 0.265
TTLL1   O95922 Probable tubulin polyglutamylase TTLL1  2.1 3.1 1 -0.44 0.581 -0.01 0.979 0.24 0.734
BANK1   Q8NDB2 B-cell scaffold protein with ankyrin repeats  2.0 1.3 1 -1.05 0.309 -1.37 0.248 -1.54 0.217
HLA-A   P10314 HLA class I histocompatibility antigen, A-32 alpha chain  2.0 21.4 5 -0.93 0.354 -1.36 0.255 -1.06 0.338
PRDX3   P30048 Thioredoxin-dependent peroxide reductase, mitochondrial  2.0 5.5 1 -0.80 0.517 -2.43 0.281 -1.40 0.339
PTPRA P18433-3 Isoform 3 of Receptor-type tyrosine-protein phosphatase alpha  2.0 1.4 1 -0.45 0.575 -0.47 0.500 -0.56 0.515
STON2 Q8WXE9-3 Isoform 2 of Stonin-2  2.0 1.2 1 -0.50 0.558 -2.31 0.153 -2.41 0.148
STXBP3   O00186 Syntaxin-binding protein 3  2.0 1.5 1 -0.64 0.507 -1.86 0.229 -2.26 0.200
TMEM63A   O94886 CSC1-like protein 1  2.0 1.1 1 -0.69 0.461 -1.78 0.218 -1.83 0.210
ATP5C1   P36542 ATP synthase subunit gamma, mitochondrial  2.0 4.0 1 -0.82 0.389 -1.13 0.299 -1.41 0.244
MFGE8   Q08431 Lactadherin  2.0 2.6 1 -0.35 0.722 -1.04 0.370 -0.24 0.778
NID1   P14543 Nidogen-1  2.0 0.9 1 -0.48 0.562 -0.66 0.452 -1.00 0.333
SERPINF1   P36955 Pigment epithelium-derived factor  2.0 3.3 1 -0.01 0.985 -0.40 0.594 0.15 0.833
TRPC6   Q9Y210 Short transient receptor potential channel 6  2.0 1.2 1 -0.48 0.544 -0.64 0.463 -0.69 0.453
YWHAQ   P27348 14-3-3 protein theta  2.0 12.2 3 -0.77 0.486 -1.91 0.259 -1.65 0.288
AQP1 P29972-3 Isoform 3 of Aquaporin-1  2.0 9.2 1 0.74 0.456 -1.45 0.275 -0.29 0.687
CORO1A   P31146 Coronin-1A  2.0 3.5 1 -0.74 0.430 -1.34 0.255 -1.61 0.216
IBTK Q9P2D0-3 Isoform 3 of Inhibitor of Bruton tyrosine kinase  2.0 3.3 1 0.43 0.738 0.69 0.603 -0.16 0.956
MASP1   P48740 Mannan-binding lectin serine protease 1  2.0 10.3 6 0.89 0.355 1.50 0.227 1.00 0.324
MFSD7   Q6UXD7 Major facilitator superfamily domain-containing protein 7  2.0 3.0 1 0.09 0.883 0.08 0.896 0.25 0.714
PPP1CA P62136-2 Isoform 2 of Serine/threonine-protein phosphatase PP1-alpha catalytic subunit  2.0 3.2 1 -0.98 0.392 -2.19 0.208 -2.15 0.214
SHBG P04278-3 Isoform 3 of Sex hormone-binding globulin  2.0 4.8 1 0.29 0.603 0.13 0.585 0.39 0.503
ZYG11B   Q9C0D3 Protein zyg-11 homolog B  2.0 0.9 1 0.09 0.871 0.23 0.713 0.04 0.902
ANXA7   P20073 Annexin A7  2.0 1.6 1 -0.64 0.477 -0.76 0.404 -0.97 0.357
ARG1   P05089 Arginase-1  2.0 3.4 1 -1.30 0.270 -1.30 0.262 -0.50 0.537
CYCS   C9JFR7 Cytochrome c (Fragment)  2.0 7.9 1 -0.32 0.681 -0.69 0.461 -0.56 0.496
IGKV6D-41   A0A0C4DH26 Immunoglobulin kappa variable 6D-41 (non-functional) (Fragment)  2.0 10.4 1 -0.49 0.528 -0.15 0.849 0.39 0.609
IGLV9-49   A0A0B4J1Y8 Immunoglobulin lambda variable 9-49  2.0 8.1 1 -0.04 0.748 -0.24 0.539 -0.17 0.744
LAMP1   P11279 Lysosome-associated membrane glycoprotein 1  2.0 2.6 1 -0.24 0.763 -0.03 0.992 -0.04 0.972
NIPSNAP3A   Q9UFN0 Protein NipSnap homolog 3A  2.0 5.7 1 -0.93 0.351 -0.69 0.441 -1.16 0.292
PSMC2   P35998 26S proteasome regulatory subunit 7  2.0 3.0 1 0.12 0.869 -1.22 0.402 -1.04 0.402
ARPC5 O15511-2 Isoform 2 of Actin-related protein 2/3 complex subunit 5  2.0 7.8 1 -0.52 0.522 -0.70 0.428 -0.76 0.400
ATP5I   P56385 ATP synthase subunit e, mitochondrial  2.0 14.5 1 -0.69 0.442 -1.44 0.241 -1.18 0.287
CA1   E5RHP7 Carbonic anhydrase 1 (Fragment)  2.0 3.6 1 0.01 0.874 0.12 0.599 0.69 0.275
CD47   Q08722 Leukocyte surface antigen CD47  2.0 2.5 1 -0.09 0.891 -1.83 0.281 -1.53 0.319
CD9   P21926 CD9 antigen  2.0 4.4 1 -0.80 0.399 -0.98 0.337 -0.89 0.365
CDS2   O95674 Phosphatidate cytidylyltransferase 2  2.0 4.3 1 -0.77 0.406 -1.08 0.311 -0.70 0.434
CTSE   P14091 Cathepsin E  2.0 2.0 1 -0.32 0.689 -1.24 0.276 -0.12 0.886
EMD   P50402 Emerin  2.0 5.9 1 -0.57 0.500 -1.17 0.290 -1.12 0.301
F13B   P05160 Coagulation factor XIII B chain  2.0 1.4 1 -0.57 0.497 -0.70 0.430 0.23 0.754
FTL   P02792 Ferritin light chain  2.0 8.6 1 0.39 0.609 0.81 0.383 1.24 0.269
GPI P06744-2 Isoform 2 of Glucose-6-phosphate isomerase  2.0 1.4 2 -0.24 0.815 -0.60 0.501 -0.39 0.731
GYPC   P04921 Glycophorin-C  2.0 20.3 3 0.88 0.359 -1.13 0.299 0.13 0.836
IGHV2-70   A0A0J9YVU5 Immunoglobulin heavy variable 2-70 (Fragment)  2.0 5.9 1 0.44 0.542 0.62 0.415 0.49 0.381
IGKV1-33   P01594 Immunoglobulin kappa variable 1-33  2.0 29.1 4 -0.27 0.766 1.18 0.277 1.71 0.199
IGLC3   P0DOY3 Immunoglobulin lambda constant 3  2.0 86.8 34 -0.12 0.886 0.32 0.665 1.22 0.272
IGLV2-18   A0A075B6J9 Immunoglobulin lambda variable 2-18  2.0 11.0 1 0.37 0.669 0.65 0.486 2.21 0.174
IGLV7-43   P04211 Immunoglobulin lambda variable 7-43  2.0 7.7 2 0.19 0.799 0.35 0.641 1.47 0.229
PRKAR2A   P13861 cAMP-dependent protein kinase type II-alpha regulatory subunit  2.0 3.7 1 -0.47 0.571 -0.57 0.505 -0.31 0.706
PROC P04070-2 Isoform 2 of Vitamin K-dependent protein C  2.0 1.5 1 0.61 0.484 -0.36 0.596 0.44 0.593
RAP2C   Q9Y3L5 Ras-related protein Rap-2c  2.0 6.0 1 -0.01 0.996 -0.73 0.426 -0.07 0.941
SH3GL2   Q99962 Endophilin-A1  2.0 2.0 1 -0.13 0.988 0.86 0.463 0.89 0.487
SLC25A3 Q00325-2 Isoform B of Phosphate carrier protein, mitochondrial  2.0 3.3 1 -1.10 0.357 -2.72 0.178 -2.29 0.200
SOD2   P04179 Superoxide dismutase [Mn], mitochondrial  2.0 6.3 1 -1.12 0.302 -1.54 0.226 -1.46 0.237
THBS4   P35443 Thrombospondin-4  2.0 1.0 1 0.65 0.477 0.28 0.728 1.17 0.306
  A0A0G2JRQ6 Uncharacterized protein (Fragment) 2.0 22.2 4 0.21 0.744 0.25 0.715 0.92 0.344
TMEM43   Q9BTV4 Transmembrane protein 43  2.0 2.3 1 -0.84 0.383 -1.36 0.253 -1.28 0.267
RTN1   Q16799 Reticulon-1  2.0 2.3 1 -1.00 0.332 -1.36 0.253 -0.19 0.813
TG   P01266 Thyroglobulin  2.0 0.8 1 0.13 0.688 0.40 0.400 0.12 0.696
PDE8A   O60658 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A  1.9 0.8 1 0.07 0.905 0.32 0.664 0.21 0.754
CAPN8   A6NHC0 Calpain-8  1.9 2.0 1 0.37 0.623 0.01 0.967 0.09 0.854
NPHS1   O60500 Nephrin  1.9 1.3 1 -0.05 0.956 0.07 0.914 -0.01 0.993
TXNDC5   Q8NBS9 Thioredoxin domain-containing protein 5  1.9 2.1 1 -0.11 0.855 -0.78 0.291 -0.64 0.431
CTSA   X6R8A1 Carboxypeptidase  1.9 1.4 1 -1.16 0.295 -2.21 0.161 -2.21 0.161
TPP2   Q5VZU9 Tripeptidyl-peptidase 2  1.8 0.8 1 -0.49 0.640 -1.40 0.322 -1.38 0.327
RILP   Q96NA2 Rab-interacting lysosomal protein  1.8 2.2 1 0.25 0.586 0.15 0.835 0.01 0.968
ABCC4   O15439 Multidrug resistance-associated protein 4  1.8 0.7 1 0.25 0.516 -0.11 0.807 -0.15 0.694
GRIK4   Q16099 Glutamate receptor ionotropic, kainate 4  1.8 1.8 1 0.01 0.944 0.24 0.611 0.21 0.751
HSP90AB1   P08238 Heat shock protein HSP 90-beta  1.8 7.6 4 -0.78 0.399 -1.59 0.219 -1.73 0.202
RRS1   Q15050 Ribosome biogenesis regulatory protein homolog  1.8 3.8 1 -0.19 0.844 -0.21 0.833 1.29 0.326
SRSF7   C9JAB2 Serine/arginine-rich-splicing factor 7  1.8 5.5 1 0.12 0.856 0.08 0.896 0.45 0.557
ICAM1   P05362 Intercellular adhesion molecule 1  1.7 1.9 1 -0.08 0.927 0.01 0.975 0.31 0.677
APC   P25054 Adenomatous polyposis coli protein  1.7 0.4 1 0.05 0.934 0.07 0.908 -0.09 0.914
BSG   P35613 Basigin  1.7 3.6 1 -0.35 0.669 -0.70 0.429 -0.49 0.546
M6PR   P20645 Cation-dependent mannose-6-phosphate receptor  1.7 5.1 1 -0.16 0.835 -1.20 0.285 -0.66 0.455
RBP4   P02753 Retinol-binding protein 4  1.7 5.0 1 -0.35 0.666 -0.61 0.480 -0.35 0.656
SAG   P10523 S-arrestin  1.7 3.2 1 0.60 0.472 -0.80 0.400 -0.03 0.982
CTNNA3   Q9UI47 Catenin alpha-3  1.7 1.0 1 -0.03 0.950 0.08 0.825 -0.03 0.974
HOOK1   Q9UJC3 Protein Hook homolog 1  1.7 1.1 1 -0.15 0.851 -0.11 0.889 0.32 0.658
NEXN   Q0ZGT2 Nexilin  1.7 2.5 1 -0.69 0.443 -1.18 0.285 -0.90 0.359
TKTL2   Q9H0I9 Transketolase-like protein 2  1.6 1.3 1 -0.01 0.996 0.05 0.970 -0.01 0.996
CD109   Q6YHK3 CD109 antigen  1.6 1.0 2 0.05 0.930 -0.70 0.439 -1.21 0.282
ADRA1D   P25100 Alpha-1D adrenergic receptor  1.6 1.9 1 0.15 0.769 0.00 0.933 0.09 0.854
PPP2R1A   P30153 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform  1.6 3.4 1 -0.49 0.524 -1.49 0.231 -1.09 0.300
ATL3   Q6DD88 Atlastin-3  1.6 1.3 1 -0.45 0.621 -1.95 0.220 -1.36 0.293
WDR35 Q9P2L0-2 Isoform 2 of WD repeat-containing protein 35  1.6 0.7 1 -0.20 0.800 -0.07 0.938 0.19 0.781
MARF1 Q9Y4F3-5 Isoform 4 of Meiosis regulator and mRNA stability factor 1  1.5 1.0 1 0.15 0.825 0.39 0.609 0.19 0.778
PERP   Q96FX8 p53 apoptosis effector related to PMP-22  1.5 3.1 1 -2.95 0.121 -2.67 0.134 -2.41 0.148
EPS15L1 Q9UBC2-2 Isoform 2 of Epidermal growth factor receptor substrate 15-like 1  1.5 2.1 1 -0.48 0.483 -0.85 0.296 -0.80 0.312
PLCG2   A0A0A0MRF9 Phosphoinositide phospholipase C  1.5 0.7 1 -0.54 0.520 -1.21 0.282 -1.36 0.253
ME2   P23368 NAD-dependent malic enzyme, mitochondrial  1.5 1.4 1 -0.45 0.578 -1.37 0.252 -1.34 0.255
MTO1   Q9Y2Z2 Protein MTO1 homolog, mitochondrial  1.4 1.1 1 0.01 0.985 0.23 0.748 0.03 0.970
PSMC4   P43686 26S proteasome regulatory subunit 6B  1.4 2.2 1 -0.35 0.666 -0.33 0.676 -0.24 0.761
TRIM39   Q9HCM9 E3 ubiquitin-protein ligase TRIM39  1.4 1.4 1 -0.04 0.960 0.04 0.914 -0.11 0.918
STX4   Q12846 Syntaxin-4  1.4 3.7 1 -0.09 0.910 -0.29 0.708 -0.64 0.470
OXNAD1   U3KQU8