Ankur Tyagi

SRF

  • MSc (Area): Biotechnology
  • ankurbiotech11@gmail.com,ankur@yenepoya.edu.in

 

Ankur Tyagi obtained his M.Sc. degree in Biotechnology from Himachal Pradesh University, Shimla, India. He worked as a Junior Research Fellow at Department of Anaesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh where he worked on anaesthetic drug trials for cognitive dysfunction and cerebral aneurysm. He also worked as Junior Research Fellow in Department of Neurosurgery, PGIMER on molecular analysis of pituitary adenoma. At CSBMM, he is involved in proteomic and phosphorotemic analysis of ACTH secreting pituitary adenoma.

Experience

  • April 2016 – till date: Senior Research Fellow, Center for Systems Biology and Molecular Medicine, Yenepoya (Deemed to be University), Mangalore, Karnataka
  • August 2015 – March 2016: Junior Research Fellow in Department of Neurosurgery, PGIMER Chandigarh
  • July 2013 – July 2015: Research trainee in Department of Anaesthesia and IC, PGIMER Chandigarh
  • December 2010 – May 2011: Academic project, antibacterial activity of medicinal plants against ESBL producing Bacteria from UTI patients, Himachal Institute of Life Sciences, Paonta Sahib, Himachal Pradesh
  • May 2010 – July 2011: Industrial Training on HPLC from Zeon Lifescinces Ltd, Paonta sahib, Himachal Pradesh
  • May 2010 – July 2011: Academic project, Identification and prevention of bacterial contamination of explants used in plant tissue culture Labs, Himachal institute of life Sciences, Paonta Sahib, Himachal Pradesh

 

 

 

 

Research interest/area

Proteomics, Biomarkers, Neuroendocrinology Disorder, Cancer Biology, Therapeutics targets. Endocrinology.

Research

Pituitary adenomas are neuro-endocrine disorders with prevalence of ~ 78 to 94 cases per 1,00,000; a majority (68%) of which are macroadenomas. Pituitary adenomas comprise approximately 10% of intracranial tumors. These are benign neoplasms which often grow invasively but very rarely progress to true carcinomas. Although classified as benign, they may cause significant morbidity in affected patients due to aberrant hormone secretion, as well as compressive effects on nearby tissues, such as optic chiasm, or the healthy pituitary leading to hypopituitarism. Majority of the pituitary adenomas are monoclonal in origin, arising from expansion of a single neoplastic cell, which has acquired some molecular defect that confers growth advantage. To date, extensive studies have been carried out in studying the gene mutation in pituitary adenomas, however, only a few anecdotal reports are available about the disease at proteomic level. The proteomic profiling of pituitary adenomas will be carried out using high resolution Fourier transform mass spectrometry. This will lead to the identification of differentially expressed proteins in pituitary adenomas as compared to non-diseased controls. This will help in identification of early detection biomarkers and help in understanding the altered signaling pathways and pathobiology of disease.

Publication

  • Yelamanchi, S. D., Tyagi, A., Mohanty, V., Dutta, P., Korbonits, M., Chavan, S., Advani, J., Madugundu, A. K., Dey, G., Datta, K. K., Rajyalakshmi, M., Sahasrabuddhe, N. A., Chaturvedi, A., Kumar, A., Das, A. A., Ghosh, D., Jogdand, G. M., Nair, H. H., Saini, K., Panchal, M., Sarvaiya, M. A., Mohanraj, S. S., Sengupta, N., Saxena, P, Subramani, P. A., Kumar, P., Akkali, R., Reshma S. V., Santhosh, R. S., Rastogi, S., Kumar, S., Ghosh, S. K., Irlapati, V. K., Srinivasan, A., Radotra, B. D., Mathur, P. P., Wong, G. W., Satishchandra, P., Chatterjee, A., Gowda, H., Bhansali, A., Pandey, A., Shankar, S. K., Anita Mahadevan, A., Prasad, T. S. K. (2018). Proteomic analysis of the human anterior pituitary gland. OMICS: A Journal of Integrative Biology, 22(12):759-769.
  • Subbannayya, Y., Karthikkeyan, G., Pinto, S. M., Kapoor, S., Tyagi, A., Pervaje, S. K., Pervaje, R. and Prasad, T. S. K. (2018). Global metabolite profiling and network pharmacology of Triphala identifies neuromodulatory receptor proteins as potential targets. Journal of Proteins and Proteomics. 9(2):101-114.
  • Kumar, M., Bhardwaj, V.S., Chauhan, P.K., Tyagi, A., Thakur, K. (2014). To Check The Prevalence And The Antibiotics Susceptibility Of Salmonella Isolated From Diarrheal Patients In Paonta Sahib, Himachal Pradesh. International Journal of Pharmacy and Integrated Life Sciences. 2(10):37- 46.
  • Tyagi, A., (2014). Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening”.Annals of Neurosciences. 21(1):22.
  • Tyagi, A., Singh, V., Kumar, M., Kumar, A., Thakur, K. (2011). Isolation and antibacterial susceptibility testing of multi drug resistant Pseudomonas aeruginosacausing urinary tract infections. Journal of Chemical and Pharmaceutical Research. 3(4):342-347.
  • Singh,V., Kaushal, S., Tyagi, A., Sharma, P. (2011). Screening of bacteria responsible for the spoilage of milk. Journal of Chemical and Pharmaceutical Research 3(4): 348-350.
  • Singh, V., Sharma, P., Kaushal, S., Sharma, R., Tyagi, A., Chauhan, P.K., (2011). Prevalence and Antibiogram Pattern of Salmonella Causing UTI Infection. Asian Journal of Pharmacy & Life Science.1 (2):179-182.
  • Choudhary, S., Singh, V., Chauhan, P.K., Tyagi, A., and Kumar, M. (2011). In vitro Antibacterial activity of eugeniajambolanaagainst streptococcus mutanscausing dental plaque formation. International Journal of Institutional Pharmacy and Life Sciences.1 (1):91-99.
  • Singh, V., Chauhan, P.K., Choudhary, S., Tyagi, A., Kaushal, S. (2011). Antibiogram pattern of streptococcus causing dental plaque. International Journal of Universal Pharmacy and Life Sciences. 1(1): 29-34.
  • Kumar, A., Chauhan, P.K., Bhardwaj, V.S., Kumar, R., Tyagi, A. (2011). In vitro Antioxidant & Phytochemical Investigations of Ethanolic extracts of Viola serpens&Morusnigra. Journal of Chemical and Pharmaceutical Research. 3(4):166-171.
  • Singh, V., Chauhan, P.K., Kaushal, S., Tyagi, A., Thakur, K., Kumar, A., Sharma, V. (2010). Isolation and Antibiogram pattern of coliisolates having heavy metal tolerance. International journal of Pharma and Biosciences. 1(3):15-21.