Dr. Shruthi Kanthaje

Postdoctoral Fellow

I completed my B.E. in Biotechnology (2005-2009) from P. A. college of Engineering, Mangalore. Later, I worked at Biological E ltd., Hyderabad, under Biotech Industrial training program, which provided me an exposure to many technical aspects biotechnology from industrial perspective. Additionally, I did my M.Tech. (Biotechnology) from Dr. D.Y. Patil University, Mumbai during 2010-2012. I also worked at ACTREC, Mumbai, where I was exposed to several aspects of cancer research. This brief experience made me realize my interests and  encouraged me to pursue this area for my higher studies. Further, I completed my Ph D in the field of cancer biology from PGIMER, Chandigarh (2013-19). My thesis involved the study of microRNAs in drug resistance and metastasis of hepatocellular carcinoma. Currently, I am working as PDF at YRC and pursuing research in cancer biology.

Postdoc/Experience

  • Junior research fellow (Nov 2012-Apr 2013) at ACTREC, Mumbai
  • Research Trainee (Jun 2011- Jul 2012) at ACTREC, Mumbai
  • Trainee under biotech industrial training program sponsored by DBT at Biological E Ltd, Hyderabad (Nov 2009-May 2010)

Awards/Honors

  • Senior research fellowship (Apr 2016-May 2018) from ICMR at PGIMER, Chandigarh
  • Qualified GATE in the year 2012
  • Qualified GRE with a score of 310 in the year 2013
  • Won first place in poster presentation at 7th International Conference and Expo on Molecular & Cancer Biomarkers, Berlin, Germany.
  • Participated in poster presentation at Global Cancer Summit, IISC, Bangalore, India.
  • Participated in “BioCamp-2012” a biotechnology leadership camp, organized by Novartis at Hyderabad, India
  • Participated in national conference on genomics, proteomics and systems biology, at Bangalore, India
  • Won First place in national level paper presentation “TVAYAA-09” held at Belgaum, India.

Research Interest/Area

Cancer Biology

Research

I am working in the field of cancer biology. Analysis of diagnostic and prognostic biomarkers for cancer, the molecular mechanisms of carcinogenesis, signaling pathways involved in metastasis and drug resistance are some of the aspects of cancer biology I am interested in. One of the biomolecule of interest is microRNAs, the small noncoding RNAs revolutionizing the world of non-coding RNAs.  Currently, I am involved in projects regarding biomarker analysis and assessing the functional aspects of lung cancer.

Publications

  1. Kanthaje S, Makol A, Chakraborti A. Sorafenib response in hepatocellular carcinoma: MicroRNAs as tuning forks. Hepatol Res. 2018 Jan;48(1):5-14. doi: 10.1111/hepr.12991. https://www.ncbi.nlm.nih.gov/pubmed/29055114
  2. Makol A, Kanthaje S, Dhiman RK, Kalra N, Chawla YK, Chakraborti A. Association of liver cirrhosis severity with type 2 diabetes mellitus in hepatocellular carcinoma. Exp Biol Med (Maywood). 2018 Feb;243(4):323-326. doi: 10.1177/1535370217744511. https://www.ncbi.nlm.nih.gov/pubmed/29186978
  3. Kumar S, Batra A, Kanthaje S, Ghosh S, Chakraborti A. Crosstalk between microRNA-122 and FOX family genes in HepG2 cells. Exp Biol Med (Maywood). 2017 Feb;242(4):436-440. doi: 10.1177/1535370216681548. https://www.ncbi.nlm.nih.gov/pubmed/27895094
  4. Singh N, Kanthaje S, Bose K. Equilibrium dissociation and unfolding of human papillomavirus E2 transactivation domain. Biochem Biophys Res Commun. 2015 Aug 7;463(4):496-503. doi: 10.1016/j.bbrc.2015.05.057. https://www.ncbi.nlm.nih.gov/pubmed/26091566
  • Biomarker potential of microRNAs in non-small cell lung cancer