Proteomics and Metabolomics
MSc (Area): Mediacl Biochemistry
Nupur Agarwal obtained her M.Sc. in Clinical Biochemistry from Kasturba Medical College, Manipal, Karnataka, India. Her master’s dissertation was “Evaluation of serum Apo lipoprotein B, CRP, Nitric Oxide and Paraoxanase in patients with Hypertension.” She has worked as a lab supervisor in Kalinga Hospital laboratory (Techmed Healthcare Ltd.) Bhubaneswar. At CSBMM, YRC, she is involved with proteomic and metabolomic analysis of infectious diseases and COPD using mass spectrometer.
Lab supervisor for a year in Kalinga Hospital laboratory (Techmed Healthcare Ltd.) Bhubaneswar
Molecular biology, Proteomics, Metabolomics, Infectious disease, COPD
Chronic Obstructive Pulmonary Disease (COPD) is a debilitating disease characterized by restriction in the airflow to the lungs resulting in chronic bronchitis and emphysema. As per the National Heart, Lung and Blood Institute (NHLBI) and the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD), it is the fourth leading cause of death worldwide. According to the 2006 reports, National Commission on Macroeconomics and Health (NCMH) estimate a higher prevalence of COPD in rural India which is increasing with time and the resulting economic burden has been estimated to be in crores. In order to better characterize the phenotypic heterogeneity and the prognosis of patients with COPD, there is currently an urgent need for the discovery and validation of reliable disease biomarkers. Mass spectrometry-based approaches have emerged as a reliable tool for identification of both potential biomarkers and therapeutic targets in multiple lung diseases including COPD, and provides a viable strategy for identifying candidate diagnostic and prognostic markers, potential drug and therapeutic targets.
At the Department of Pulmonary Medicine, Yenepoya Medical College and Hospital, on an average, 30 cases with COPD are referred every month. Majority of these cases have a prior history of smoking. A significant number of women over the age of 50 years with no history of smoking are affected with COPD and undergoing treatment. The aim of my Ph.D. research topic is to carry out comparative proteomics and metabolomics analysis of patients in different stage of COPD (GOLD I – GOLD IV) and identify biomarker for each stage, thus helping in early diagnosis and prognosis of disease progression. This study will also help in validation of the biomarkers identified in the previous studies till date on patients with COPD. It will provide leads to predict the severity of the disease and manage treatment modality for the improved clinical outcome.
- Arul Amuthan, ShabariAnandh, Syed Musharraf, Nupur Agarwal, Vasudha Devi, Revathi P Shenoy,Effect of Notchikudineer (Vitexnegundo aqueous extract) on surgically induced Endometriosis in Sprague Dawley rats. IJCS; 2015; 4(3):35-43.