Sweta

JRF

  • MSc (Area): Genomic Science
  • shweta.shweta16@gmail.com

I have completed my M.Sc. in Genomic Science from Central University of Kerala in 2018. My master’s thesis focussed on identification of Long non-coding RNAs (LncRNAs) in early development and differentiation of presomitic mesoderm (PSM), the progenitor of musculoskeletal system. I joined Yenepoya Research Centre to continue my research towards deciphering the role of ncRNAs in Skeletal muscle myogenesis.

Research Interest/ Area

ncRNAs, Molecular Biology, Muscle Biology and Cardiovascular Biology

Research

The mammalian genome is pervasively transcribed (>80%) into RNA transcripts but only a small proportion (<2%) is utilized for the synthesis of functional proteins. several studies in the past years have highlighted the role of the ncRNAs in fine tuning the gene regulatory networks in various biological processes including development and progression of diseases.

Skeletal muscle contributes to about 60% of the body weight and can regenerate in response to injury. The process of myogenesis involves the activation, proliferation and differentiation of muscle precursor cells to form multinucleate myotubes. Dysregulation of myogenesis process leads to various disorders such as muscular dystrophies, neuromascular degenerative diseases, as well as aging (sarcopenia) which can result in severely compromised quality of life. Understanding the role of ncRNAs in myogenesis process will provide more insights into the molecular understanding and might help in the identification of novel therapeutic targets.

Publications

Sweta S, Dudnakova T, Sudheer S, Baker AH, Bhushan R. Importance of Long Non-coding RNAs in the Development and Disease of Skeletal Muscle and Cardiovascular Lineages. Frontiers in Cell and Developmental Biology, October 2019.