Proteomics of In Vivo Models of Ischemic Stroke: A Systematic review with a Systems Biological Perspective

Mapping DEPSIS into TTD and DrugBank databases

Proteins from DEPSIS (DEregulated Proteome Signature of Ischemic Stroke) (N= 90) were searched in the Therapeutic Target Database (TTD) to find target types, associated diseases, and drug names. Subsequently, DrugBank was used to gather detailed information about these drugs, including their therapeutic categories and mechanisms of action. In case of discrepencies between TTD and DrugBank databases, entries from DrugBank were used.

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Gene Symbol Protein Name Target Type Drug Name Disease Mechanism of Action
ALB Albumin ST Abiraterone Metastatic castration-resistant prostate cancer Steroid 17-alpha-hydroxylase/17,20 lyase inhibitor
PLG Plasminogen ST Anistreplase Myocardial infarction and Pulmonary emboli Plasminogen activator
TTR Transthyretin ST 1-Naphthylamine-5-sulfonic acid NA NA
C1S Complement C1s component ST Sutimlimab Cold agglutinin disease (CAD) Complement C1s subcomponent-Inhibitor Antibody
GANAB Neutral alpha-glucosidase AB ST Miglitol Diabetes mellitus type 2 Lysosomal alpha-glucosidase antagonist
ANXA1 Annexin A1 SDT Difluprednate Ocular pain Glucocorticoid receptor agonist
C3 Complement C3 SDT Pegcetacoplan Paroxysmal nocturnal haemoglobinuria Complement C3 inhibitor
DPYSL2 Dihydropyrimidinase related protein 2 SDT Lacosamide Convulsion; Epilepsy, Diabetic neuropathy Slow inactivation of voltage-gated sodium channel
IDH1 Isocitrate dehydrogenase (NADP(+)) 1 SDT Ivosidenib Cholangiocarcinoma; Acute myeloid leukaemia Isocitrate dehydrogenase [NADP] cytoplasmic inhibitor
IDH3A Isocitrate dehydrogenase [NAD] subunit alpha SDT Enasidenib Acute myelogenous leukaemia; Glioma Isocitrate dehydrogenase [NADP], mitochondrial inhibitor
PRKCE Protein kinase C epsilon SDT Meprobamate Anxiety disorder; Malaria Gamma-aminobutyric acid receptor subunit alpha-1 agonist
PRKCG Protein kinase C gamma SDT Midostaurin Acute myeloid leukaemia; Systemic mastocytosis Protein kinase C alpha type antagonist
SERPINA1 Alpha-1-antitrypsin SDT Pentetic acid Emphysema; Alpha-1 antitrypsin deficiency Transuranium elements chelators
MBP Myelin basic protein CTT Tiplimotide Multiple Sclerosis MBP Binder
HP Haptoglobin CTT Zinc chloride Zinc Deficiency syndromes B1 bradykinin receptor agonist
GAPDH Glyceraldehyde-3-Phosphate Dehydrogenase CTT Artenimol Plasmodium falciparum infections Actin, cytoplasmic 2 ligand
APOE Apolipoprotein E CTT Zinc chloride Zinc Deficiency syndromes B1 bradykinin receptor agonist
APOA1 Apolipoprotein A-I CTT Copper Occipital Horn Syndrome and Menke's disease Amyloid-beta precursor protein binder
ALDH2 Aldehyde dehydrogenase CTT Amyl Nitrite Angina Atrial natriuretic peptide receptor 1 agonist
ANXA5 Annexin A5 CTT Copper Occipital Horn Syndrome and Menke's disease Amyloid-beta precursor protein binder
HSPD1 60 kDa heat shock protein CTT Copper Occipital Horn Syndrome and Menke's disease Amyloid-beta precursor protein binder
PKM Pyruvate kinase M2 CTT Artenimol Plasmodium falciparum infections Actin, cytoplasmic 2 ligand
HBB Hemoglobin subunit beta CTT Copper Occipital Horn Syndrome and Menke's disease Amyloid-beta precursor protein binder
CPB2 Carboxypeptidase B2 CTT Prothrombin Acute major bleeding Fibrinogen alpha chain cleavage
PPP2CA Serine/threonine PP2A-alpha CTT Vitamin E Cardiovascular diseases, Diabetes mellitus NA
UCHL1 Ubiquitin Carboxyl-Terminal Esterase L1 PT Phenethyl Isothiocyanate Leukemia, Lung Cancer NA
CTSB Cathepsin B PT 2-Pyridinethiol NA NA
USP14 Ubiquitin carboxyl-terminal hydrolase 14 PT Phenethyl Isothiocyanate Lymphoproliferative Disorders NA
HSPA8 Heat shock cognate 71 kDa protein LRT Artenimol Plasmodium falciparum infections Actin, cytoplasmic 2 ligand
DLG4 Disks Large Homolog 4 LRT Guanidine Eaton-Lambert syndrome Aldehyde dehydrogenase, mitochondrial inhibitor
FGG Fibrinogen Gamma Chain Isoform Gamma LRT Alteplase Myocardial infarction, Ischemic stroke, Pulmonary emboli Fibrinogen gamma chain binder
ANXA2 Annexin A2 LRT Artenimol Plasmodium falciparum infections Actin, cytoplasmic 2 ligand
AHCY Adenosylhomocysteinase LRT Copper Occipital Horn Syndrome and Menke's disease Amyloid-beta precursor protein binder
ACO2 Aconitate hydratase LRT Isocitric Acid NA NA
CLU Clusterin LRT Copper Occipital Horn Syndrome and Menke's disease Amyloid-beta precursor protein binder
AHSG Alpha-2-HS-glycoprotein LRT Copper Occipital Horn Syndrome and Menke's disease Amyloid-beta precursor protein binder
VDAC2 Non-selective voltage-gated ion channel VDAC2 LRT Aluminium monostearate NA Troponin C, slow skeletal and cardiac muscles stimulator
PDXP Pyridoxal phosphate phosphatase LRT Pyridoxine phosphate NA Ornithine decarboxylase inhibitor
ST, Successful Target; SDT, Successful Drug Target; CTT, Clinical Trial Target; PT, Preclinical Target; LRT, Literature Reported Target

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