Deregulated proteome from brain
A total number of unique 288 deregulated proteins were manually extracted from the ivProt studies (n=76). Forty four unique proteins were deregulated in more than one independent study. These proteins were grouped into 4 categories based on sample location, model type, occlusion/ reperfusion, and regulation; 1) Group I- Consistent Regulation Matched Variables, 2) Group II- Consistent Regulation Unmatched Variables, 3) Group III- Inconsistent Regulation, *Group III has not been discussed in the main text.
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| Gene Symbol | Protein Name | Model Type (Study Count) | Sex (Study Count) | Occlusion/ Reperfusion (h/h) | Location/ Regulation |
| Group I: Consistent Regulation Matched Variables | |||||
| Dpysl2 | Dihydropyrimidinase-Like 2 | pM (7) | M (7) | 24/0 | Cor(↑) |
| Hspd1 | Heat Shock Protein Family D (Hsp60) Member 1 | pM (7) | M (6), F (1) | 24/0 | Cor(↑) |
| Pdxp | Pyridoxal Phosphatase | pM (2) | M (2) | 24/0 | Cor(↑) |
| Ahcy | Adenosylhomocysteinase | pM (8) | M (8) | 24/0 | Cor(↓) |
| Ak1 | Adenylate Kinase 1 | pM (2) | M (2) | 24/0 | Cor(↓) |
| Apoa1 | Apolipoprotein A1 | pM (4) | M (4) | 24/0 | Cor(↓) |
| Dnm1l | Dynamin 1-Like | pM (3) | M (3) | 24/0 | Cor(↓) |
| Eif4a2 | Eukaryotic Translation Initiation Factor 4A2 | pM (3) | M (3) | 24/0 | Cor(↓) |
| Eno2 | Enolase 2 | pM (5) | M (5) | 24/0 | Cor(↓) |
| Gapdh | Glyceraldehyde-3-Phosphate Dehydrogenase | pM (3) | M (3) | 24/0 | Cor(↓) |
| Hpca | Hippocalcin | pM (7) | M (6), F (1) | 24/0 | Cor(↓) |
| Idh1 | Isocitrate Dehydrogenase (Nadp(+)) 1 | pM (6) | M (6) | 24/0 | Cor(↓) |
| Idh3a | Isocitrate Dehydrogenase (Nad(+)) 3 Catalytic Subunit | pM (3) | M (3) | 24/0 | Cor(↓) |
| Pea15 | Proliferation And Apoptosis Adaptor Protein 15 | pM (6) | M (5), F (1) | 24/0 | Cor(↓) |
| Pkm | Pyruvate Kinase M1/2 | pM (3) | M (3) | 24/0 | Cor(↓) |
| Ppp2r2b | Protein Phosphatase 2, Regulatory Subunit B, Beta | pM (4) | M (4) | 24/0 | Cor(↓) |
| Prdx2 | Peroxiredoxin 2 | pM (4) | M (4) | 24/0 | Cor(↓) |
| Pvalb | Parvalbumin | pM (5) | M (4), F (1) | 24/0 | Cor(↓) |
| Txn1 | Thioredoxin 1 | pM (3) | M (3) | 24/0 | Cor(↓) |
| Uchl1 | Ubiquitin C-Terminal Hydrolase L1 | pM (6) | M (6) | 24/0 | Cor(↓) |
| Group II: Consistent RegulationUnmatched Variables | |||||
| Alb | Albumin | tM (6) | M (6) | 2/4, 1/24, 2/12, 1.5/24, 1.5/24, 2/24 | Hem(↑), Cor(↑), Cor(↑), Hem(↑), Cor(↑), Hem(↑) |
| Pgk1 | Phosphoglycerate Kinase 1 | pM (1), tM (3), pM (1) | M (6) | 2/0, 2/4, 2/24, 2/48, 96/0 | Hem(↑), Hem(↑), Hem(↑), Cor(↑), Cor(↑) |
| Aldoc | Aldolase, Fructose-Bisphosphate C | tM (3), pM (1) | M (4) | 1.5/24, 0.5/48, 2/48, 96/0 | Hem(↑), Cor(↑), Cor(↑), Cor(↑) |
| Gfap | Glial Fibrillary Acidic Protein | tM (4) | M (4) | 2/24, 2/24, 2/168, 2/336 | Hem(↑), Cor(↑), Cor(↑), Cor(↑) |
| Sptan1 | Spectrin, Alpha, Non-Erythrocytic 1 | pM (1), tM (3) | M (4) | 24/0, 2/12, 0.5/48, 2/48 | Cor(↑), Cor(↑), Cor(↑), Cor(↑) |
| Vim | Vimentin | tM (4) | M (4) | 2/24, 2/24, 2/168, 2/336 | Hem(↑), Cor(↑), Cor(↑), Cor(↑) |
| Uchl1 | Ubiquitin C-Terminal Hydrolase L1 | pM (1), tM (2) | M (3) | 2/0, 2/4, 2/24 | Hem(↑), Hem(↑), Hem(↑) |
| P4hb | Prolyl 4-Hydroxylase Subunit Beta | tM (3) | M (3) | 1/24, 0.5/48, 2/48 | Cor and Str(↑), Cor(↑), Cor(↑) |
| Pgam1 | Phosphoglycerate Mutase 1 | pM (1), tM (1), pM (1) | M (3) | 2/0, 2/24, 96/0 | Hem(↑), Hem(↑), Cor(↑) |
| Tpm3 | Tropomyosin 3 | pM (1), tM (2) | M (3) | 2/0, 2/4, 2/24 | Hem(↑), Hem(↑), Hem(↑) |
| Anxa5 | Annexin A5 | tM (3) | M (3) | 1.5/72, 1.5/336, 4/672 | Peri(↑), Peri(↑), Hem(↑) |
| C3 | Complement C3 | tM (3) | M (3) | 2/4, 1.5/24, 2/24 | Hem(↑), Hip(↑), Hem(↑) |
| Gap43 | Growth Associated Protein 43 | pM (1), tM (2) | M (3) | 2/0, 2/4, 2/24 | Hem(↑), Hem(↑), Hem(↑) |
| Hspa1b | Heat Shock Protein Family A (Hsp70) Member 1B | tM (3) | M (3) | 2/24, 2/168, 2/336 | Cor(↑), Cor(↑), Cor(↑) |
| Mdh1 | Malate Dehydrogenase 1 | tM (3) | M&F (2), M (1) | 1/24, 1/24, 1.5/24 | Hem(↓), Hem(↓), Hem(↓) |
| Tf | Transferrin | tM (3) | M (3) | 2/4, 1.5/24, 2/24 | Hem(↑), Hip(↑), Hem(↑) |
| Tnfrsf11b | Tnf Receptor Superfamily Member 11B | tM (3) | NA (1), NA (1), NA (1) | 1/3, 1/6, 1/20 | Hem(↑), Hem(↑), Hem(↑) |
| Dpysl2 | Dihydropyrimidinase-Like 2 | tM (1), pM (1) | M (2) | 1.5/24, 24/0 | Hem(↑), Str(↑) |
| Hspd1 | Heat Shock Protein Family D (Hsp60) Member 1 | tM (1), pM (1) | M (2) | 1.5/24, 24/0 | Hem(↑), Str(↑) |
| Eno2 | Enolase 2 | tM (1), pM (1) | M&F (1), M(1) | 1/24, 24/0 | Hem(↓), Str(↓) |
| Aco2 | Aconitase 2 | tM (2) | M (1), M&F (1) | 0.5/48, 1/24 | Cor(↓), Hem(↓) |
| Ctsb | Cathepsin B | tM (2) | M (2) | 2/168, 2/336 | Cor(↑), Cor(↑) |
| Mdh2 | Malate Dehydrogenase 2 | tM (2) | M (2) | 1.5/24, 2/48 | Hem(↑), Cor(↑) |
| Ppp2ca | Protein Phosphatase 2 Catalytic Subunit Alpha | tM (2) | M (2) | 0.5/48, 2/48 | Cor(↑), Cor(↑) |
| Stxbp1 | Syntaxin Binding Protein 1 | tM (2) | NA (1), NA (1) | 1/6, 1/20 | Hem(↓), Hem(↓) |
| Syn2 | Synapsin II | tM (2) | M (2) | 1/24, 2/48 | Cor(↑), Cor(↑) |
| Tpi1 | Triosephosphate Isomerase 1 | pM (2) | M (2) | 2/0, 96/0 | Hem(↑), Cor(↑) |
| Eno1 | Enolase 1 | tM (1), pM (1) | M (2) | 1.5/24, 3/0 | Hem(↓), Hip(↓) |
| Group III: Inconsistent Regulation | |||||
| Gapdh | Glyceraldehyde-3-Phosphate Dehydrogenase | tM (2) | M (2) | 1.5/3, 1.5/24 | Cor(↑), Hem(↓) |
| Pkm | Pyruvate Kinase M1/2 | tM (2) | M (2) | 1.5/24, 96/0 | Hem(↓), Cor(↑) |
| Txn1 | Thioredoxin 1 | tM (1), pM (1) | M (2) | 2/24, 24/0 | Cor(↑), Str(↓) |
| Gene Symbol | Protein Name | Model Type (Study Count) | Sex (Study Count) | Occlusion/ Reperfusion (h/h) | Location/ Regulation |
| tM, tMCAO; pM, pMCAO; M, Male; F, Female; Cor, Cortex; Hem, Hemisphere; Peri, Peri infarct; Hip, Hippocampus; Str, Striatum | |||||
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