Proteomics of In Vivo Models of Ischemic Stroke: A Systematic review with a Systems Biological Perspective

Clinical vs in vivo consensus proteins

The curated 534 deregulated proteins from the MCAO model were compared with 166 deregulated proteins curated from 10 clinical proteomics studies. A total of 28 proteins were deregulated in both clinical and animal samples. Out of these 28 proteins, 20 proteins (70%) showed identical regulation.

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Gene Symbol Protein Name Clinical in vivo
Sample Regulation Sample Regulation
ALB Albumin Preproprotein Ischemic ipsilateral hemisphere Up Cerebral cortex Down
ANXA2 Annexin A2 Isoform 2 Putamen/ thalamus/ parietal lobe Up Cerebral cortex Down
DLG4 Disks Large Homolog 4 Isoform 6 Human blood sample (Serum) Up Cerebral cortex Down
UCH-L1 Ubiquitin Carboxyl-Terminal Esterase L1 Human CSF Sample and Blood Up Cerebral cortex Down
ALDH2 Aldehyde Dehydrogenase, Mitochondrial Isoform 2 Precursor Ischemic ipsilateral hemisphere Down NA Up
APOE Apolipoprotein E Isoform B Precursor Plasma Down NA Up
FGG Fibrinogen Gamma Chain Isoform Gamma-A Precursor Plasma Down Cerebral cortex Up
HSPA2 Heat Shock-Related 70 Kda Protein 2 Putamen/ thalamus/ parietal lobe Down Cerebral cortex Up
ANXA5 Annexin A5 Putamen/ thalamus/ parietal lobe Up NA Up
ANXA1 Annexin A1 Putamen/ thalamus/ parietal lobe Up Hippocampus Up
APOA1 Apolipoprotein A-I Isoform 3 Precursor Ischemic ipsilateral hemisphere Up Cerebral cortex Up
C3 Complement C3 Preproprotein Ischemic ipsilateral hemisphere Up Hippocampus Up
FGA Fibrinogen Alpha Chain Isoform Alpha Precursor Plasma Up Hippocampus Up
FGB Fibrinogen Beta Chain Isoform 8 Preproprotein Ischemic ipsilateral hemisphere Up Cerebral cortex Up
GFAP Glial Fibrillary Acidic Protein Isoform 4 Ischemic ipsilateral hemisphere Up Cerebral cortex Up
HP Haptoglobin Ischemic ipsilateral hemisphere Up Cerebral cortex Up
MBP Myelin Basic Protein Isoform 2 Putamen/ thalamus/ parietal lobe Up Cerebral cortex Up
SERPINA1 Alpha-1-Antitrypsin Precursor Ischemic ipsilateral hemisphere Up Cerebral cortex Up
TF Serotransferrin Isoform 3 Ischemic ipsilateral hemisphere Up Cerebral cortex Up
VIM Vimentin Putamen/ thalamus/ parietal lobe Up Cerebral cortex Up
ALDOC Fructose-Bisphosphate Aldolase C Ischemic ipsilateral hemisphere Down Cerebral cortex Down
DPYSL2 Dihydropyrimidinase-Related Protein 2 Isoform 3 Ischemic ipsilateral hemisphere Down Cerebral cortex Down
GAPDH Glyceraldehyde-3-Phosphate Dehydrogenase Isoform 4 Ischemic ipsilateral hemisphere Down NA Down
IDH3A Isocitrate Dehydrogenase [NAD] Subunit Alpha, Mitochondrial Precursor Ischemic ipsilateral hemisphere Down Cerebral cortex Down
HPX Hemopexin Precursor Plasma Down NA Down
HSPA8 Heat Shock Cognate 71 Kda Protein Isoform 2 Ischemic ipsilateral hemisphere Down Hippocampus Down
ENO1 Enolase 1 Ischemic ipsilateral hemisphere Down Hippocampus Down
ACTG1 Actin, Cytoplasmic 2 Ischemic ipsilateral hemisphere Down NA Down
Gene Symbol Protein Name Clinical in vivo
Sample Regulation Sample Regulation

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