Consensus proteins between in vivo and clinical proteomics datasets
The curated unique 309 deregulated proteins from animal tissue and body fluids were compared with 166 deregulated proteins curated from 10 clinical proteomics studies. A total of 39 proteins were deregulated in both clinical and animal samples. Out of these 39 proteins, 33 proteins (85%) showed identical regulation.
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| Protein | Clinical Proteomics | ivProt Studies | ||||
| Sample; Disease/Location | Sampling Time (PMI/time from index event) | Regulation | Sample, Model Type | Sampling Time (h) | Regulation | |
| ATP5B | PM brain infarct; P, PL | Median PMI 3.5 h | Down | Cor, tM | 1/24 | Down |
| DLAT | PM brain infarct; P, PL | Median PMI 3.5 h | Down | Hem, tM | 1/24 | Down |
| DPYSL2 | IC, PI; TACI | PMI 6 h | Down | Cor, tM | 1.5/3 | Down |
| ENO1 | IC, PI; TACI | PMI 6 h | Down | Hem, tM | 1.5/24 | Down |
| GANAB | PI; TACI | PMI 6 h | Down | Cor, tM | 1.5/3 | Down |
| GAPDH | IC, PI; TACI | PMI 6 h | Down | Hem, tM | 1.5/24 | Down |
| IDH3A | IC; TACI | PMI 6 h | Down | Cor, pM | 24/0 | Down |
| PDHB | PM brain infarct; T, PL | Median PMI 3.5 h | Down | Cor, tM | 1.5/3 | Down |
| VDAC2 | PM brain infarct; P, PL | Median PMI 3.5 h | Down | Hem, tM | 1.5/24 | Down |
| A2M | Pla; LACI | Median Delay: 42 Days | Up | Pla, pM | 1.5/24 | Up |
| ALB | IC, PI; TACI | PMI 6 h | Up | Hem, tM | 2/4 | Up |
| ANXA1 | PM brain infarct; P, T, PL | Median PMI 3.5 h | Up | Hip, tM | 1.5/24 | Up |
| ANXA2 | PM brain infarct; T, PL | Median PMI 3.5 h | Up | Hip, tM | 1.5/24 | Up |
| ANXA5 | PM brain infarct; T, PL | Median PMI 3.5 h | Up | PI, tM | 1.5/72 | Up |
| APOA1 | IC, PI; TACI | PMI 6 h | Up | Cor, pM | 24/0 | Up |
| ARHGDIA | IC; TACI | PMI 6 h | Up | Cor, pM | 24/0 | Up |
| C3 | IC, PI; TACI | PMI 6 h | Up | Hem, tM | 2/4 | Up |
| CLU | Ser; AIS | Within 24 h | Up | Hip, tM | 1.5/24 | Up |
| DLG4 | Ser; AIS | NA | Up | Cor, tM | 1.5/7.5 | Up |
| FGA | Pla; LACI | Median Delay: 42 Days | Up | Hip, tM | 1.5/24 | Up |
| FGB | IC; TACI | PMI 6 h | Up | Hip, tM | 1.5/24 | Up |
| FGG | Pla; LACI | Median Delay: 42 Days | Up | Hip, tM | 1.5/24 | Up |
| GFAP | IC; TACI | PMI 6 h | Up | Hem, tM | 2/24 | Up |
| HBB | IC, PI; TACI | PMI 6 h | Up | Hem, pM | 2/0 | Up |
| HP | IC, PI; TACI | PMI 6 h | Up | NA, tM | 2/48 | Up |
| ITIH4 | Pla; LACI | Median Delay: 42 Days | Up | Hip, tM | 1.5/24 | Up |
| MBP | PM brain infarct; P, PL | PMI 6 h | Up | Cor, tM | 2/72 | Up |
| NSF | IC, PI; TACI | PMI 6 h | Up | Cor, pM | 96/0 | Up |
| PLG | Pla; LACI | Median Delay: 42 Days | Up | Hip, tM | 1.5/24 | Up |
| PRDX1 | CRM; MMI | After 24 h | Up | Cor, tM | 2/24 | Up |
| RAB1A | IC; AIS | Median PMI 5.5 h | Up | Ser, pM | 2/0 | Up |
| TF | IC; TACI | PMI 6 h | Up | Hem, tM | 2/4 | Up |
| VIM | PM brain infarct; T, PL | Median PMI 3.5 h | Up | Hem, tM | 2/24 | Up |
| ALDOC | IC, PI; TACI | PMI 6 h | Down | Hem, tM | 1.5/24 | Up |
| APOA2 | Pla; LACI | Median Delay: 42 Days | Down | Hip, tM | 1.5/24 | Up |
| ATP5A1 | PM brain infarct; P, PL | Median PMI 3.5 h | Down | Hem, pM | 2/0 | Up |
| HPX | Pla; LACI | Median Delay: 42 Days | Down | Hem, tM | 2/4 | Up |
| LDHA | IC; PI | PMI 6 h | Down | Cor, pM | 96/0 | Up |
| HSPA8 | IC; TACI | PMI 6 h | Up | Cor, tM | 2/24 | Down |
| Protein | Clinical proteomics | ivProt Studies | ||||
| Sample; Disease/Location | Sampling time (PMI/time from index event) | Regulation | Sample, Model Type | Sampling time (h) | Regulation | |
| PM, Post Mortem; P, Putamen; PL, Parietal Lobe; IC, Infarct Core; PI, Peri-infarct; TACI, Total Anterior Circulation Infarcts; T, Thalamus; Pla, Plasma; LACI,Lacunar Infarction; Ser, Serum; AIS, Acute Ischemic Stroke; CRM, Cerebral Microdialysate ; MMI, Malignant MCA infarction; PMI, Post Mortem Interval; Cor, Cortex; Hem, Hemisphere; PI, Peri Infarct; Hip, Hippocampus | ||||||
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