Muhammad Nihad A. S.
Regenerative and Cancer Stem Cells
MSc (Area): Regenerative Medicine
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Muhammad Nihad A.S. had done his Master’s in Regenerative Medicine from School of Regenerative Medicine, Manipal Academy of Higher Education. He worked on yolk sac membrane angiogenesis assay for his MSc dissertation from Sir Parashurambhau College, Pune, where a modified version of the yolk sac membrane assay was established. He was ardent about joining labs working on stem cells which brought him to Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre. Currently he is a Junior Research Fellow/PhD Student working on regenerative stem cells and cancer stem cells. He is competent in cell culture techniques.
- August 2017 to May 2018 – Trainee – Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre
- November 2017 to October 2018 – Clinical Research Coordinator for Zika Trial (BBIL ZIKV)– Department of General Medicine, Yenepoya Medical College Hospital
- May 2018 to Till date – PhD Student – Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre
- November 2018 to Till date – Junior Research Fellow – Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre
Stem Cells, Regenerative Medicine, Tissue Engineering
My research involves isolation and expansion of Wharton’s Jelly mesenchymal stem cells (WJMSCs) from human umbilical cord and studying their interaction with cancer stem cells isolated from the cancer cell lines. Umbilical cord, which is usually discarded after child birth, is an abundant source of stem cells. Mesenchymal stem cells (MSCs) can easily be isolated from the umbilical cord using explant culture method. These cells have been proven to migrate towards tumour and induce apoptosis in cancer cells. Cancer stem cells are the immortal cells within the tumour that can both self-renew by dividing and give rise to many cell types that constitute the tumour, can therefore form tumours. Cancer therapy can only be successful if these cancer stem cells are killed. The migratory and anti-cancerous property of WJMSCs will be utilized in my research. These WJMSCs will be pre-conditioned physiologically to enhance their stemness and migratory properties and how this conditioning affect the cancer stem cells will be looked into.
As MN, Deshpande R, Kale VP, Bhonde RR, Datar SP. Establishment of an in ovo chick embryo yolk sac membrane (YSM) assay for pilot screening of potential angiogenic and anti-angiogenic agents. Cell Biol Int. 2018 Nov;42(11):1474-1483. doi: 10.1002/cbin.11051. Epub 2018 Sep 11. PubMed PMID: 30136736.