Rex D. A. B.

ICMR-SRF

  • Core Skills:
    Proteomics
  • MSc (Area): Biochemistry
  • MPhil (Area): Biochemistry
  • PGDBI (Area): Bioinformatics
  • rexprem@yenepoya.edu.in

Rex D. A. B studied Biochemistry at both under- and post-graduate level from Madurai Kamaraj University and Bharathidasan University respectively. He did a commendable cardiovascular research during his M.Phil dissertation at Bharathiar University. His research interests include Molecular Parasitology, Cardiovascular, and Neurodegenerative disorders. His technical expertise includes transfection of malarial parasite cell lines like 3D7, D10, NF54 Line E, and gene editing techniques such as CRISPR- Cas 9, Aptamers, and glms (ribozyme). He is currently working in Mass spectrometry-based proteomic analysis.

Experience

S.No. Positions held Name of the Institute
1 Project Assistant (DST Funded Project)

 

PSG College of Technology
2 Project Fellow (DST Funded Project) ICMR-National Institute of Traditional Medicine (NITM)
3 Senior Research Fellow Yenepoya

(Deemed to be University)

Awards/Honors

Best Poster award at 87th Annual meeting and Conference of Society of Biological Chemists (India)

Research interest/Area

Molecular Parasitology, cardiovascular, and neurodegenerative disorders

Research

Our current work to identify temporal signaling events induced by IL-33 using a quantitative proteomic approach by using high- throughput techniques such as mass spectrometry (MS) to identify large-scale identification of proteins possible. This comprehensive proteomic analysis will generate a resource of IL-33-mediated changes covering early as well as late signaling events, such as recruitment of adaptors to the activated receptor, phosphorylation of downstream proteins, and alterations in protein abundance. Some of the proteins identified in the study may even be associated with inflammatory and pathological conditions and these may serve as diagnostic markers in several pathological conditions including cancer, inflammatory diseases, autoimmune deficiency and infectious diseases.

Publication

Advani, J., Verma, R., Chatterjee, O., Rex, D. A. B, R., Najar, M. A., Ravishankara, N., Suresh, S., Pachori, P. K., Gupta, U. D., Pinto, S. M., Chauhan, D. S., Tripathy, S. P., Gowda, H. & Prasad, T. S. K. 2019. Rise of Clinical Microbial Proteogenomics: A Multiomics Approach to Nontuberculous Mycobacterium-The Case of Mycobacterium abscessus UC22. OMICS, 23, 1-16.

Pinto, S. M., Subbannayya, Y., Rex, D. A. B., Raju, R., Chatterjee, O., Advani, J., Radhakrishnan, A., Keshava Prasad, T. S., Wani, M. R. & Pandey, A. 2018. A network map of IL-33 signaling pathway. J Cell Commun Signal, 12, 615-624.

Rex D.A.B. Selenium Enriched Mushrooms as a Food Supplement for Prevention of Neurodegenerative Diseases.International Journal of Pharmacy and Pharmaceutical Sciences. Vol 6 Issue 10, Nov 2014

 Rex D.A.B, R .Raj Kumar.Growth of nanotechnology in targeting carcinogens – a comparision on synthesis of gold and Zinc Nanoparticles. Journal of Biomaterials and Tissue Engineering Vol. 4, 1–9, 2014.. (American Scientific Publishers). DOI: http://dx.doi.org/10.1166/jbt.2014.1217

Rex D. A. B and Ragavan B .Studies on Phytochemicals, Antioxidant and cytotoxicity effect of Hybanthus enneaspermus. International Journal of Pharmacy and Pharmaceutical Sciences, Vol 6, Issue 6, 2014, 567-572.

Karthikeyan A, Siva G, Sujitha S P, Rex D. A. B and Chidambaranathan N. Development of Anti hyperglycemic activity of the ethanolic seed extract of Vernonia anthelminticum wild. International Journal of Green Pharmacy 2008; 10: 209 – 211.DOI: 10.4103/0973-8258.44733