Sadiya Bi Shaikh
Epithelial Mesenchymal Transition
MSc (Area): Zoology
I have completed my Master’s degree in Zoology (2014-2016) from GOA University, India. During my master’s thesis, I worked on project entitled “Alteration of metabolism due to monocrotophos toxicity in bivalves villoritta cyprinoides, (hanley, 1866)”. I joined Yenepoya Research Centre in May, 2017, I am currently working on micro RNAs in epithelial mesenchymal transition and lung fibrosis. I have expertise in Animal handling and molecular techniques like Western blot, qRT-PCR for gene expression Studies, Electrophoresis, ELISA, Immunohistochemistry, Immunofluroscence, Gelatin zymography
- Summer internship on project titled as “Study of cancer stem cell upregulation by HPV using VM model in oral squamous cell carcinoma patient samples” at Chittaranjan National Cancer Institute, Kolkata(May-Nov 2015)
- Internship on project titled “Approaches for prevention of Biofilm formation by Gardnerella vaginalis” at Department Molecular Immunology and Microbiology, National Institute for Research in Reproductive Health (NIIRH), Mumbai. (Jan-Mar 2016)
- Project Trainee at Tata Memorial Centre Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Mumbai.(October – December, 2016)
- Project Trainee at National Centre for Antarctic and Ocean Research (NCAOR), GOA. (May-June, 2016)
- Post-Graduate Merit Scholarship for the year 2014-2016
- UGC-CSIR _LECTURSHIP, December-2016, December-2017
- Completed GIAN course on “LUNG INFLAMMATION AND RESPIRATORY DISEASES” organized department of studies in biochemistry post graduate centre, Mangalore University, India and obtained EXCELLENT grade in it.
- Won “Budding Scientist Award” for poster entitled “Curcumin regulates the IL-17A mediated p53-fibrinolytic system and alveolar epithelial to mesenchymal transition in BLM induced lung injury and fibrosis” at Third International conference on Nutraceuticals and Chronic Diseases (INCD-2018) held from 14th– 16th September, 2018.
- Won “Organizing Committee Visually Excellent Poster ” and S.Murthy award, “Development of Drug From Plant Source” for poster entitled ”Curcumin suppresses the up-regulation of bleomycin mediated epithelial to mesenchymal transition during lung injury and fibrosis in vitro and in vivo” at 45th National Conference of Association of Clinical Biochemists of India (ACBICON-2018) held from 24th – 27th October at Kala Academy, Goa.
- Travel Grant approved by DST-SERB for attending American Thoracic Society (ATS) 2019, Dallas United States.
- Travel Grant approved by CSIR for attending American Thoracic Society (ATS) 2019, Dallas United States.
- Abstract Scholarship Recipient and Won “ATS Youthful Performer Award” for paper entitled “Curcumin Suppresses the Alveolar Inflammation and Modulates the p53-fibrinolytic System and Epithelial to Mesenchymal Transition during Lung Injury and Fibrosis In Vitro and In Vivo” at American Thoracic Society (ATS) International Conference 2019 organized by American Thoracic Society, held on May 17 – 22 , 2019 at Dallas, Texas, United States Of America.
- Won Young Scientist Award” and “Best Oral Presentation Award” Curcumin stands strong in attenuating p53-fibrinolytic system in TGF-β1 mediated alveolar epithelial to mesenchymal transition by in-vitro and in-silico analysis ” oral presentation at Fourth International conference on Nutraceuticals and Chronic Diseases (INCD-2019) held at IIT GUWAHATI, Assam-India from 23rd – 25th September, 2018.
- Sanctioned ICMR-SRF fellowship
- Travel Award recipient at 11th PSI annual meeting and International Conference held at National Dairy Research Institute, Karnal-Haryana from 2nd -4th December 2019.
Acute Lung Injury, Pulmonary Fibrosis, Micro RNAs, COPD
My research is focused on targeting the pro-inflammatory cytokine Interleukin 17-A (IL-17A) mediated fibrinolytic system in Epithelial Mesenchymal Transition (EMT) focusing its role during acute lung injury which ultimately leads to lung fibrosis. Using a natural polyphenol curcumin as an intervention. My work is also designed on targeting micro RNAs specifically miRNA 200a,b and c which are known to play important role in EMT during pulmonary fibrosis. we are interested to find out the interaction of miR200c with IL-17A, as well as with p53 and fibrinolytic system whose components includes uPA (urokinase plasminogen activator) and PAI-1 (Plasminogen Activator inhibitor-1) to see what role miRNA 200a,b and c plays in fibrinolytic system.
Further, my research interest includes:
- Translational research to develop a novel product as an intervention for pulmonary fibrosis
- To find out role of few novel MicroRNAs in EMT
- To develop novel early detection devices of lung diseases (Social benefits)
- Shaikh SB, Prabhu A, Bhandary YP. Targeting anti‐aging protein sirtuin (Sirt) in the diagnosis of idiopathic pulmonary fibrosis. Journal of cellular biochemistry. 2019 May;120(5):6878-85.
- Shaikh SB, Gouda MM, Bhandary YP. Inflammatory and fibrinolytic system in acute respiratory distress syndrome. Lung. 2018 Oct 1;196(5):609-16.
- Gouda MM, Shaikh SB, Chengappa D, Kandhal I, Shetty A, Bhandary Y. Changes in the expression level of IL-17A and p53-fibrinolytic system in smokers with or without COPD. Molecular biology reports. 2018 Dec 1;45(6):2835-41.
- Shaikh SB, Prabhu A, Bhandary YP. Interleukin 17-A a potential therapeutic target in chronic lung diseases.Endocrine, Metabolic & Immune Disorders – Drug Targets
- Shaikh SB, Prabhu A, Bhandary YP. Curcumin Suppresses Epithelial Growth Factor Receptor (EGFR) and Proliferative Protein (Ki 67) in Acute Lung Injury and Lung Fibrosis In Vitro and In Vivo. Endocrine, metabolic & immune disorders drug targets. 2019 Aug. DOI: 10.2174/1871530319666190823160230
- Yashodhar P. Bhandary, Sadiya Bi Shaikh, Dr. Irfan, “Biomarkers for Detection/ Diagnosis of Pulmonary Disorders and Uses Thereof”, Indian Patent, Provisional specification, 2019, 201941051398.
- Yashodhar P. Bhandary, Sadiya Bi Shaikh, Mr. Mohd. Altaf Najar, Dr. Ashwini Prabhu, Dr. Prashant Kumar Modi and Dr. T. S. Keshava Prasad,“Molecular Biomarkers for Detection of Idiopathic Pulmonary Fibrosis”, Indian Patent, Provisional specification, 2019, 201941048222.