Saptami Uday Kanekar
Allied health and Basic sciences
Ms. Saptami U. Kanekar completed Master’s degree in MSc Microbiology (2013-2015) from Karnatak University Dharwad, India. In her master’s thesis, she worked on a project entitled “Biological treatment of wastewater using Chlorella pyrenoidosa & Scenedesmus abundans”. Have expertise in microbiological and molecular biology techniques. She joined Yenepoya Research Centre on 15th January 2016 and working on bacterial quorum sensing mechanism.
- ICMR-Senior Research fellowship 2019
- MSc Microbiology first rank holder and Gold medalist- 2016
Microbiology, Microbial pathogenesis, Antimicrobial resistance, Biotechnology, Molecular biology, Biochemistry, Applied Botany.
Project title: Modulation of quorum sensing in selected Gram-negative pathogenic bacteria using novel molecules
Summary: The aim of this study is to assess the modulation of quorum sensing Chromobacterium violaceum and Pseudomonas aeruginosa in presence of inhibitors and inducer by time dependent gene regulation mechanism. Further to establish quorum sensing targeted antibiotic therapy using selected antibiotics and novel quorum sensing inhibitors. Cuurently there is high interest in manipulating bacterial quorum sensing signaling systems for diverse applications such as ecological control in agriculture, food industry and antivirulence in medicine. We want to study the modulation of the quorum sensing mediated genes in the presence of inhibitors and inducers at a temporal scale. Hence, this study proposes to determine novel strategies involving quorum sensing mediated targets using certain inhibitory molecules for the improved drug efficacy by identifying the genes regulated in the Gram-negative pathogen system. Naturally derived quorum sensing inhibitors are molecules that agonize or antagonize quorum sensing which can structurally mimic the AHLs/ signalling molecules, and such competitive binding is effective to block activation of AHL-mediated virulence in the opportunistic pathogens. In addition to that, quorum sensing inhibitors can also affect the integrity of biofilms and thus, will make the bacteria more susceptible to conventional antibiotics. This serves as an advantage as it can help to minimize the possibility of the bacteria from becoming resistant. The knowledge generated may be applied in healthcare set up for the management of Chromobacterium violaceum, Pseudomonas aeruginosa, Acinetobacter baumannii and similar bacterial infections.
- Rekha PD, Vasavi HS, Vipin C, Saptami K, Arun AB. A medicinal herb Cassia alata attenuates quorum sensing in Chromobacterium violaceumand Pseudomonas aeruginosa. Letters in applied microbiology. 2017; 64(3):231-8.
- Santosh R, Selvam MK, Kanekar SU, Nagaraja GK, Kumar M. Design, Synthesis, DNA Binding, and Docking Studies of Thiazoles and Thiazole‐Containing Triazoles as Antibacterials. ChemistrySelect. 2018; 3(14):3892-8.
- Snoussi M, Noumi E, Punchappady-Devasya R, Trabelsi N, Kanekar S, Nazzaro F, Fratianni F, Flamini G, De Feo V, Al-Sieni A. Antioxidant properties and anti-quorum sensing potential of Carum copticum essential oil and phenolics against Chromobacterium violaceum. Journal of Food Science and Technology. 2018: 1-9.
- Santosh R, Selvam MK, Kanekar SU, Nagaraja GK. Synthesis, Characterization, Antibacterial and Antioxidant Studies of Some Heterocyclic Compounds from Triazole‐Linked Chalcone Derivatives. Chemistry Select. 2018; 3(23):6338-43.
- Kamat V, Nayak SP, Adiga G, Rajeena AC, Kanekar SU, Rekha PD. Design, facile synthesis and pharmacological evaluation of hybrid 1, 3, 4-thiadiazole linked chalcone confined via sulphur bridge. Heterocyclic letters. 2018 Jan 1;8(3):671-8.
- Noumi E, Snoussi M, Alreshidi M, Rekha PD, Saptami K, Caputo L, De Martino L, Souza L, Msaada K, Mancini E, Flamini G. Chemical and Biological Evaluation of Essential Oils from Cardamom Species. Molecules. 2018 Oct 30;23(11):2818.