Cancer Stem Cells Biology
MSc (Area): Bio-technology
Mr. Utsav Sen is a recipient of Senior Research Fellowship from ICMR in 2018. He has completed his Master’s degree in Biotechnology from The Oxford College of Science 2015, Bangalore University, India. He worked at the Department of Health and Hygiene, Unilever R& D, Bengaluru. Also, he worked on expression, purification and crystallization of transcription anti-termination proteins in the Department of Crystallography and Molecular biology, Saha Institute of Nuclear Physics, Kolkata. He also worked as project trainee at Molecular Medicine lab, Bose Institute, Kolkata. Currently, he is working on Cancer stem cells and regenerative stem cells. His expertise is in techniques such as cell culture techniques, FACS, Immunofluorescence, Western Blot, Real time PCR.
- January 2015- July 2015 in Industry (Hindustan Unilever R&D, Bangalore)
- August 2015- November 2017 as a Junior Research Fellow (JRF) at Yenepoya Research Centre, Yenepoya Deemed to be University, Mangalore
- November 2017-May 2018 as a Senior Research Fellow (SRF) at Yenepoya Research Centre, Yenepoya Deemed to be University
- June 2018- Till date: as an ICMR-Senior Research Fellow (SRF) at Yenepoya Research Centre, Yenepoya Deemed to be University
- 2nd Best oral and poster award in Anveshan-2018 in South (India) Zone, by Association for Indian university (AIU, New Delhi)
- 2nd best oral and poster award in Anveshan-2018 in India by Association for Indian University (AIU, New Delhi)
- Senior Research Fellowship (SRF) awarded by Indian Council for Medical Research (ICMR, New Delhi) in 2018
Cancer biology, Cancer Stem cell, Regenerative Stem cell, Molecular Biology, Cell Biology
It is known that cancer is a cluster of different cell types. It implies the cells are present in a tumor microenvironment, are different from each other. There resemble to be diverse degrees of aggressiveness in the different cancer cells. It has been hypothesized that the most destructive cancer cells are resistant towards the chemotherapeutic drugs and also towards radiation therapy. These aggressive cells are termed cancer stem cells (CSCs) because of their resemblance to healthy stem cells, such as self-renewal proliferation and differentiation. CSCs were already found in solid tumors of the breast, colon, pancreas, ovary, prostate and brain. A new generation of thinking in cancer treatment focuses on attacking the roots of cancer, the CSCs. Here, in Stem cells and regenerative medicine centre, we are targeting the cancer stem cells in vitro, by isolating them from the heterogeneous population. Moreover, we are treating with different drugs to establish a stable cancer stem cell-based therapeutics and also we are looking for the detailed mechanism of action of each drug on breast and colon cancer stem cells.
Roy N, Sen U, Chaudhuri SR, Muthukumar V, Moharana P, Paira P, Bose B, Gauthaman A, Moorthy A. Mitochondria specific highly cytoselective Iridium (III)-Cp* dipyridophenazine (dppz) complexes as cancer cell imaging agents. Dalton Transactions, Royal Society of Chemistry. 2021.
Bose B‡, Kapoor S‡, Sen U‡, As MN, Chaudhury D, Shenoy S. Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C (UV-C) Damage. Journal of visualized experiments: JoVE. 2020 Feb 15(156). ‡Equally contributing first authors
Sen U, Chaudhury D, Shenoy P. S, Bose B. Differential sensitivities of triple‐negative breast cancer stem cell towards various doses of vitamin C: An insight into the internal antioxidant systems. J Cell Biochem, Wiley.2020;1–18. (IF 4.2)
- Roy N‡, Sen U‡, Madaan Y, Muthukumar V, Vardhan S, Sahoo SK, Panda D, Bose B, Paira P. Mitochondria-targeting Click-Derived Pyridinyltriazolylmethylquinoxaline based Y-shaped Binuclear Luminescent Ru (II) and Ir (III) Complexes as Cancer Theranostic Agents. 2020. Inorganic Chemistry, ACS (IF 4.85). ‡ Equally contributing first authors
- Mondal A‡, Sen U‡, Nilmadhab Roy, Muthukumar, Venkatesan; Sahoo, Suban, Priyankar Paira, Bipasha Bose: One-pot Synthesis of Ru(II)-p-cymene-2-aryl benzimidazole (BIZ), benzothiazole (BTZ) and benzoxazole (BOZ) Scaffolds: the influence of Regioisomer on Cytotoxicity and Reactivity Towards DNA and Protein. 2020. (Dalton Transaction, Royal Society of Chemistry IF 4.1). ‡ Equally contributing first authors
- Chaudhury D, Sen U, Bhat NN, Sahoo BK, Shenoy P S, Bose B. Lung damage by thoron progenies versus possible damage redemption by lung stem cells: a perspective. International Journal of Radiation Biology. 2020 Sep 7(just-accepted):1-36.
- Shenoy PS, Sen U, Kapoor S, Ranade AV, Chowdhury CR, Bose B. Sodium fluoride induced skeletal muscle changes: Degradation of proteins and signaling mechanism. Environmental pollution. 2019 Jan 1; 244:534-48.
- Bose B, Sen U, Shenoy PS. Breast Cancer Stem Cell Therapeutics, Multiple Strategies versus Using Engineered Mesenchymal Stem Cells with Notch Inhibitory Properties: Possibilities and Perspectives. Journal of cellular biochemistry. 2018 Jan; 119(1):141-9.
- Sen U, Shenoy PS, Bose B. Opposing effects of low versus high concentrations of water soluble vitamins/dietary ingredients Vitamin C and niacin on colon cancer stem cells (CSCs). Cell biology international. 2017 Oct;41(10):1127-45