Dr. Arnab Datta

Dr. Arnab Datta

Associate Professor
  • PhD, School of Biological Sciences, Nanyang Technological University, Singapore
  • MPharm, Department of Pharmaceutical Technology, Jadavpur University, India
  • arnabdattaju@gmail.com

Profile

 

Dr. Datta received industrial, translational and basic research trainings in pharmacology, drug development and discovery, quantitative proteomics, phosphoproteomics, bioinformatics, neuroscience, kidney physiology and systems biology from Jadavpur University, and Torrent Research Center (India), Nanyang Technological University, and Yong Loo Lin School of Medicine (Singapore) and National Institutes of Health (USA) under the supervision of prominent research mentors (Late Prof. Tuhinadri Sen, Prof. Sze Siu Kwan, Prof. Klaus Heese, and Dr. Mark A. Knepper. Dr. Datta holds certificates on ‘Management’ and ‘Research Ethics’ from NIH that is tailored for scientists. He is acting as an evaluator for several grant agencies and invited reviewer for journals such as Journal of Neuropathology and Experimental Neurology, Proteomics, and Experimental Gerontology. He works as honorary consultant and actively collaborates with pharma and biotech industries on industry-relevant projects.

 

Experience

  • Associate Professor (Apr 2023 – Till date) – Yenepoya Research Center, Yenepoya (Deemed to be University), Mangalore, Karnataka
  • Assistant Professor (Nov 2019- Mar 2023) – Yenepoya Research Center, Yenepoya (Deemed to be University), Mangalore, Karnataka
  • Visiting Fellow (May 2015 – Sep 2019) – National Institutes of Health, Bethesda, MD, USA
  • Research Fellow (Jun 2013 – Feb 2015) – School of Biological Sciences, Nanyang Technological University, 50 Nanyang Ave, Singapore
  • Research Associate (Mar 2012 – Jun 2013) – Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive, Singapore
  • Scientist II (Feb 2006 – Dec 2007) – Discovery Pharmacology, Torrent Research Centre, Torrent Pharmaceuticals Ltd., India
  • Research Associate (Jul 2005 – Dec 2005) – Formulation and Development, Rubicon Research Pvt. Ltd., Mumbai, India

Awards/ Honors

  • Visiting Fellowship, National Institutes of Health, USA (May 2015 – Sep 2019)
  • NIH Travel Grant for poster presentation at Annual Conference of US HUPO at Rockville, MD, USA (Mar 2019)
  • Travel Grant from American Society of Nephrology for poster presentation at ASN Kidney Week at San Diego, CA, USA (Oct 2018)
  • First prize for Outstanding Poster Presentation at 4th Annual Meeting-American Physiological Society at Washington DC, USA (Oct 2017)
  • NIH Travel Grant for poster presentation at Gordon Research Conference on Lysosomes & Endocytosis at Andover, NH, USA (Jun 2016)
  • Student Bursary for poster presentation at 9th Human Proteome Organization World Congress at Sydney, Australia (Sep 2010)
  • Nanyang Technological University Research Scholarship, Singapore (Jan 2008 – Dec 2012, PhD program)
  • University Gold Medal, Master of Pharmacy Examination, Jadavpur University, India (Dec 2005)
  • University Grant Commission Scholarship, Govt. of India, Area: Pharmaceutical Science, Graduate Aptitude Test for Engineers Score: 96.94 percentile (Aug 2003 – Jun 2005, Master’s program)
  • Merit Medal for academic excellence, Alumni Association of Jadavpur University, India (April 2003, Bachelor’s Program)

 

 

Research

Research Interest/ Area

Ischemic stroke, Dementias, Target and Biomarker Discovery, Pharmacology, Protein Mass Spectrometry, Bioinformatics and Systems Biology, Artificial intelligence

Research

Our laboratory uses a multi-disciplinary systems approach to elucidate the underlying mechanisms of ischemic stroke and dementias. We seek to understand how perturbations in protein expression and post-translational modifications such as enzyme-controlled phosphorylation and non-enzymatic deamidation mediate neurovascular dysfunction in brain injury and repair. A bench-to-bedside approach comprising of in vitro, in vivo models, human post-mortem brain tissue and patient plasma sample is adapted to detect the deregulated proteins at the cellular and tissue levels in pre-clinical models and clinical samples. We use a combination of tools, including but not limited to biochemical, flow cytometric, molecular biological assays and protein mass spectrometry. These laboratory approaches are complemented by parallel informatics, Bayesian statistics, and extensive mining of prior literature to propose and validate new hypothesis. In addition, our systems level curated datasets will provide new information resource for the basic and clinical research community and facilitate meta-analysis. The ultimate aim is to assess novel strategies for neuroprotection and restoration through the discovery of potential therapeutic targets and biomarkers.

Our research is currently funded by DST-SERB, ICMR, and Yenepoya (deemed to be University). We believe in sharing expertise and are open to collaboration with like-minded laboratories, researchers, industries, and clinicians to tame difficult scientific questions and problems. We are actively collaborating with national and international experts from academia, clinic, and industry.

 

Publications                                                                                                                                            Full list:

  1. Datta A*, Chen C, Gao YG, Sze SK* (2022) Quantitative Proteomics of Medium-Sized Extracellular Vesicle-Enriched Plasma of Lacunar Infarction for the Discovery of Prognostic Biomarkers International Journal of Molecular Sciences 23: 11670 (* Co-corresponding author)
  2. Babu M, Singh N, Datta A (2022) In Vitro Oxygen Glucose Deprivation Model of Ischemic Stroke: A Proteomics-Driven Systems Biological Perspective. Mol Neurobiol 59: 2363-2377
  3. Datta A, Yang CR, Salhadar K, Park E, Chou CL, Raghuram V, Knepper MA (2021) Phosphoproteomic identification of vasopressin-regulated protein kinases in collecting duct cells. Br J Pharmacol 178: 1426-1444
  4. Datta A, Yang CR, Limbutara K, Chou CL, Rinschen MM, Raghuram V, Knepper MA (2020) PKA-independent vasopressin signaling in renal collecting duct. Faseb j 34: 6129-6146
  5. Datta A*, Chai YL, Tan JM, Lee JH, Francis PT, Chen CP, Sze SK, Lai MKP* (2017) An iTRAQ-based proteomic analysis reveals dysregulation of neocortical synaptopodin in Lewy body dementias. Molecular brain 10: 36 (* Co-corresponding author)

Patents

Siu Kwan Sze, Christopher Chen, Arnab Datta, Palau Xavier Ramon Gallart.  Plasma Microvesicle Biomarkers for Ischemic Stroke. United States patent WO 2015/038065 A1, Mar 19, 2015

We are looking for Ph.D. candidates who are interested to work in the interface of neuroscience, proteomics, systems biology, pharmacology, drug discovery, bioinformatics, and artificial intelligence. It is expected that as a member of our team, one will have an opportunity to be trained in diverse skill sets such as survival surgery on small rodents to big data integration using an in-silico Bayes approach. We actively collaborate with experts from the USA, Singapore, and Canada to provide useful international exposure to our Ph.D. students.