Dr. Raghu Bhushan
PhD, Biology, Department of Biology, Freie University, Germany
- Assistant Professor (2017-till date) – Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore-575018
- Research Fellow (2016– August 2017) – Centre for Cardiovascular science, University of Edinburgh, UK. Project: Understanding the role of LncRNAs in Pulmonary arterial hypertension (PAH) and Atherosclerosis.
- Postdoctoral Researcher (2013 – January, 2016) – Sanofi-BCRT (Sanofi-Genzyme Pharmaceuticals and Berlin-Brandenburg Center for Regenerative Therapies), Charité, Berlin, Germany. Project: Establishing novel therapeutic strategy for Marfan syndrome (cardiovascular complications) using BA4 (anti-elastin) antibody.
- Researcher – Max Planck Institute for Molecular Genetics, Berlin, Germany. Project: Modulation of miR-221 and miR-222 processing by ADARs
- Young Faculty Award by “The International Academy of Cardiovascular Sciences (IACS)”, India
- Member, Royal Society of Biology, UK
- Member, Biochemical society, UK
- Member, British Heart Foundation, UK
- Research fellowship from British Heart Foundation (BHF), UK
- Scholarship from Max Planck Society, Germany
- Scholarship from DFG, German Research Foundation for Doctoral work, Germany
- Scholarship from Centre for International Cooperation, FreieUniversität Berlin, Germany
- Scholarship from Dahlem Research School, FreieUniversität Berlin, Germany
- BMBF scholarship for Bioinformatics training at Cologne University, Cologne, Germany
- Member, Internal audit committee 2018, Yenepoya Research Centre, Yenepoya University
- Member Secretary, Institutional Committee for Stem Cell Research (IC-SCR), Yenepoya (Deemed to be University), Mangalore, India
Cardiovascular and Skeletal muscle biology, cardiovascular diseases, Non-coding RNAs and Genomics
Cardiac diseases can affect every age group but with a prevalence in >=65 years older age group population. In India, a quarter of all the mortality is contributed by CVD. According to prospective studies and Global Burden of Disease estimates, the burden of CVDs in India is mainly due to increase in tobacco consumption or smoking, dietary habits (Less vegetable and fruit intake) prevalence of Hypertension, less physical activity etc. (Prabhakaran D et al., Circulation. 2016).
My major research interests are to understand the mechanisms governing cardiovascular complications and aortic diseases (such as atherosclerosis, pulmonary arterial hypertension, and aortic aneurysms) with an emphasis on the role and function of non-coding RNAs (microRNAs and LncRNAs) in the above mentioned disease pathologies. Furthermore, the ultimate goal is to apply translational research to identify and unravel the novel biomarkers/potential therapeutic target(s) (using state of art of genomics (next generation sequencing, RNA-seq analysis) and proteomics (high-resolution Mass spectrometry) to functionally characterize them in respective Mouse models/human cell systemsfor better therapeutics towards human health andmedicine.
- Importance of long noncoding RNAs in the development and disease of skeletal muscle and cardiovascular lineages Sweta S, Tanya D, Sudheer S, Baker AH*, Bhushan R*. Front. Cell Dev. Biol., 2019 (*Corresponding author) (Impact Factor: 5.2)
- An integrative systems approach identifies novel candidates in Marfan syndrome-related pathophysiology. Bhushan R*, Altinbas L, Jäger M, Zaradzki M, Kallenbach K, Timmermann B, Clayton N, Zhu Y, Kararigas G, Robinson PN. J Cell Mol Med. 2019 (*First and corresponding author) (Impact Factor: 4.5)
- Extracellular vesicle cross-talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF-β signalling: implications to PAH vascular remodelling De la Cuesta F, Passalacqua, I, Rodor J, Bhushan R, Denby L, Baker AH. Cell Communication and Signaling, 2019 (Impact Factor: 5.3)
- A Novel Plaque Enriched Long Non-coding RNA in Macrophage Phagocytosis Regulation (PELOTON). J Hung, JP Scanlon, J Rodor, AD Mahmoud, M Fontaine, L Temmerman, J Kacynski, R Bhushan, EAL. Biessen, DE Newby, JC Sluimer, AH Baker. Arteriosclerosis, Thrombosis, and Vascular Biology, 2019 (Impact Factor: 6.3)
- MiR-497∼195 cluster microRNAs regulate osteoblast differentiation by targeting BMP signaling. Grünhagen J, Bhushan R, Degenkolbe E, Jäger M, Knaus P, Mundlos S, Robinson PN, Ott CE. J. Bone Miner Res. 2015 May;30 (5):796-808. (Impact Factor: 6.3)