FACULTY

Dr. T. S. Keshava Prasad

Professor and Deputy Director
  • PhD, Goa University, India
  • MSc-Biosciences, Mangalore University, India
  • keshav@yenepoya.edu.in

Profile

Dr. T. S. Keshava Prasad is a recipient of Young Investigator Award from the Department of Biotechnology, Government of India.  He is leading IOB’s efforts on the development of the Human Protein Reference Database, which is cited over 3000 times. He also contributed to a draft map of human proteome, which was featured on the cover of prestigious journal Nature. These two papers are ranked second and sixth among the Top 10 Publications with Indian affiliation in the area of Biology and Biochemistry as evaluated by the Department of Science and Technology (DST), Government of India with help of two independent international entities – Thomson Reuters and Elsevier and published in the “India’s Research Landscape: Output, Collaboration and Comparative Performance – Bibliometric Studies” on February 17, 2016.

Dr. Prasad was actively involved in the development of Plasma Proteome Database (http://www.plasmaproteomedatabse.org), and database of human signaling pathways – NetPath (http://www.netpath.org). Dr. Prasad has successfully established proteomics and bioinformatics facilities and research teams in three Institutes – Institute of Bioinformatics, Bangalore;  National Institute of Mental Health and Neurosciences, Bangalore; and Yenepoya (Deemed to be University), Mangalore. His research group is now increasingly focusing on genomic, proteomic and metabolomic approaches to investigate caners, infectious diseases, and neurological disorders and cancers. He has several national and international collaborations. He is a member of editorial boards of reputed journals and reviewer for several national and international journals.

Experience

  • Postdoctoral Fellow (March 3, 2004- December 31, 2005) – Institute of Bioinformatics, Bangalore
  • Faculty Scientist (January 1, 2006-January 3, 2018) – Institute of Bioinformatics, Bangalore
  • Officer-Incharge (July 05, 2012 – July 30, 2017) – Proteomics and Bioinformatics Laboratory, Neurobiology Research Centre, NIMHANS, Bangalore
  • Professor and Deputy Director (Ad-Hoc) (June 1, 2015 – January 3, 2018) – YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, University Road, Mangalore -575018
  • Faculty Scientist (Adjunct) (January 4, 2018- present) – Institute of Bioinformatics, Bangalore
  • Professor and Deputy Director (January 3, 2018 – present) – Center for Systems Biology and Molecular Medicine, Yenepoya University, University Road, Mangalore -575018

Awards/Honors

  • Young Investigator, Department of Biotechnology, Government of India
  • Visiting Scientist at Boone Laboratory, Centre for Cellular and Biomolecular Research in University of Toronto, Canada
  • Member, IC-SCRT – Stempeutics Research Pvt. Ltd., Manipal, India
  • HUPO Young Investigator, Madrid, Spain
  • F1000 Travel Award from the Wellcome Trust – Kolymbari, Greece
  • Travel award from National Institute of Genetics, Tokyo, Japan

Research

Research Interest/Area

  • Genomics, proteomics and bioinformatics
  • Infectious diseases including tuberculosis and malaria
  • Human signaling and metabolic pathways
  • Development of biological databases
  • Molecular targets of traditional medicines
  • Metabolomics of human diseases and traditional medicines
  • Proteogenomics and genome annotation

Research

Dr. Prasad is using multipronged omics approaches to discover potential actionable molecules and signaling pathways in human diseases relevant to India including cancers, infectious diseases and neurological disorders, which will probably be helpful in the early identification and better management of these diseases. He is investigating the molecular targets of traditional medicines in the quest for novel therapeutic targets in cancers. He is also investigating antigens of pathogens secreted into body fluids or excreted into urine in order to develop novel diagnostics to detect pathogens and infectious diseases. He is characterizing metabolites present in the medicinal plants and traditional medicines using global metabolomics, which will provide platform to identify new biological active principles.

Publications                                                                                                                                         All List :

  1. Advani, J., Verma, R., Chatterjee, O., Pachouri, P. K., Upadhyay, P., Singh, R., Yadav, J., Naaz, F., Ravikumar, R., Buggi, S., Suar, M., Gupta U. D., Pandey, A., Chauhan, D. S., Tripathy, S. P., Gowda, H. and Prasad, T. S. K.*(2019). Whole genome sequencing of Mycobacterium tuberculosis clinical isolates from India reveals genetic heterogeneity and region specific variations that might affect drug susceptibility. Frontiers in Microbiology 10, 309
  2. Verma, R., Pinto, S., Patil, A. H., Advani, J., Subba, P., Kumar, M., Sharma, J., Dey, G., Ravikumar, R., Buggi, S., Satishchandra, P., Sharma, K., Suar, M. T., Srikanth, C., Singh, D., Gowda, H., Pandey, A., Gandotra, S. and Prasad, T. S. K.* (2017). Quantitative proteomic and phosphoproteomic analysis of H37Ra and H37Rv strains of Mycobacterium tuberculosis.Journal of Proteome Research.
  3. Kim, M. S., Pinto, S. M., Getnet, D., Nirujogi, R. S., Manda, S. S., Chaerkady, R., Madugundu, A. K., Kelkar, D. S., Isserlin, R., Jain, S., Thomas, J. K., Muthusamy, B., Leal-Rojas, P., Kumar, P., Sahasrabuddhe, N. A., Balakrishnan, L., Advani, J., George, B., Renuse, S., Selvan, L. D. N., Patil, A. H., Nanjappa, V., Radhakrishnan, A., Prasad, S., Subbannayya, T., Raju, R., Kumar, M., Sreenivasamurthy, S. K., Marimuthu, A., Sathe, G. J., Chavan, S., Datta, K. K., Subbannayya, Y., Sahu, A., Yelamanchi, S. D., Jayaram, S., Rajagopalan, P., Sharma, J., Murthy, K. R., Syed, N., Goel, R., Khan, A. A., Ahmad, S., Dey, G., Mudgal, K., Chatterjee, A., Huang, T. C., Zhong, J., Wu, X., Shaw, P. G., Freed, D., Zahari, M. S., Mukherjee, K. K., Shankar, S., Mahadevan, A., Lam, H., Mitchell, C. J., Shankar, S. K., Satishchandra, P., Schroeder, J. T., Sirdeshmukh, R., Maitra, A., Leach, S. D., Drake, C. G., Halushka, M. K., Prasad, T. S. K., Hruban, R. H., Kerr, C. L., Bader, G. D., Iacobuzio-Donahue, C. A., Gowda, H. and Pandey, A. (2014). A draft map of the human proteome. Nature. 509, 575-581.
  4. Nanjappa, V., Thomas, J. K., Marimuthu, A., Muthusamy, B., Radhakrishnan, A., Sharma, R., Khan, A. A., Balakrishnan, L., Sahasrabuddhe, N., Kumar, S., Jhaveri, B. N., Sheth, K. V., Khatana, R. K., Shaw, P. G., Srikanth, S. M., Mathur, P. P., Shankar, S., Nagaraja, D., Christopher, R., Mathivanan, S., Raju, R., Sirdeshmukh, R., Chatterjee, A., Simpson, R. J., Harsha, H. C., Pandey, A. and Prasad, T. S. K.(2014). Plasma Proteome Database as a resource for proteomics research: 2014 update. Nucleic Acids Research. 42, D959-D965.
  5. Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V., Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Rahiman, B. A., Prasad, T. S. K., Lin, J., Houtman, J. C. D., Desiderio, S., Renauld, J., Constantinescu, S. N., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. and Pandey, A. (2010) NetPath: A public resource of curated signal transduction pathways. Genome Biology11, R3.

Books/Book Chapters

  1. Pinto, S. M., Subbannayya, Y. and Prasad, T. S. K. (2019). “Functional Proteomic Analysis to Characterize Signaling Crosstalk” In: Functional Proteomics: Methods and Protocols. X. Wang and M. Kuruc Editors. New York, NY, Springer New York: 197-224.
  2. Subbannayya, Y., Pinto, S. M., Gowda, H. and Prasad, T. S. K*. (2016). Proteogenomics for understanding oncology: recent advances and future prospects. Expert Review of Proteomics. 13, 297-308.
  3. Mohanty, A. K., Prasad, T. S. K., Garg, S. and Kumar, A. (2014). “Proteogenomics of Vector Mosquitoes: Progress and Prospects” In: Major Tropical Diseases: Public Health Perspective. Ashwani Kumar, Savio Rodrigues and Amit Dias Editors. Broadway Publication House. pp 38-50.
  4. Prasad, T. S. K., Kandasamy, K. and Pandey, A. (2009) “Human Protein Reference Database and Human Proteinpedia as discovery tools for systems biology.” In: Reverse Chemical Genetics: Methods and Protocols. Hisashi Koga, Editor. (Humana Press, Totowa, New Jersey, USA) Methods in Molecular Biology 577, 67-79.

Patents

 

  1. Yashodhar P. Bhandary, Sadiya Bi Shaikh, Mr. Mohd. Altaf Najar, Dr. Ashwini Prabhu, Dr. Prashant Kumar Modi and Dr. T. S. Keshava Prasad,“Molecular Biomarkers for Detection of Idiopathic Pulmonary Fibrosis”, Indian Patent, Provisional specification, 2019, 201941048222.
  2. Prasad, T. S. K., Kumar, A., Pandey, A., Gowda, H., Ramesha, K. P., Mohanty, A.K., Kumar, M. and Pinto, S. M., “Novel Peptides for Developing Anti-Malaria Vaccines and Diagnostic Kits”, Indian patent, 2017, No: 201741013642.