RESEARCH SCHOLARS

Muhammad Nihad A. S.

SRF
  • Regenerative and Cancer Stem Cells
  • MSc (Area): Regenerative Medicine
  • nihad511@gmail.com , muhammadnihad@yenepoya.edu.in

Profile

Muhammad Nihad A S had done his Master’s in Regenerative Medicine from Manipal Institute of Regenerative Medicine, Manipal Academy of Higher Education, Bangalore, India. He worked on yolk sac membrane angiogenesis assay for his MSc dissertation from Sir Parashurambhau College, Pune, where a modified version of the yolk sac membrane assay was established. He was ardent about joining labs working on stem cells which brought him to Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre. He is competent in various cell culture techniques. Currently he is a Senior Research Fellow/PhD Student working on the differentiation of pluripotent stem cells into pancreatic beta islets.

Experience

  • Senior Research Fellow (January 2022 to till date) – Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre
  • Trialect Fellow (September 2019 to October 2019) – Mario Negri Institute for Pharmacological Research, Milan, Italy
  • Junior Research Fellow (November 2018 to December 2021) – Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre
  • Clinical Research Coordinator for Zika Trial (BBIL ZIKV) (November 2017 to October 2018) – Department of General Medicine, Yenepoya Medical College Hospital
  • Trainee  (August 2017 to May 2018)  – Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre

 

Research

 

Research Interest/Area:

Stem Cells, Regenerative Medicine, Tissue Engineering and Cell culture

Research:

Pluripotent stem cells, given its indefinite expansion and potential to differentiate into any cell type of the human body, are the key candidates in regenerative medicine. Differentiation of pluripotent stem cells into pancreatic beta islets can replace the need for cadaveric donors needed for the islet transplantation in diabetic patients. Various protocols for pancreatic beta cell differentiation have been established in the past two decades using cocktails of growth factors and molecules. One of the major concerns about all these protocols were the final yield of functional beta islets and the cost of generating them. Hence, we are exploring a novel approach of differentiation using bioactive lipids, which are known to play various roles in cellular physiology, that can be an economical and more efficient.

Publications

  1. Nihad M, Shenoy P S, Bose B. Cell therapy research for Diabetes: Pancreatic β cell differentiation from pluripotent stem cells. Diabetes Res Clin Pract. 2021 Nov;181:109084. doi: 10.1016/j.diabres.2021.109084. Epub 2021 Oct 19. PMID: 34673084.
  2. Bose B, Kapoor S, Nihad M. Induced Pluripotent Stem Cell Derived Human Lung Organoids to Map and Treat the SARS-CoV2 Infections In Vitro. Adv Exp Med Biol. 2021;1312:1-17. doi: 10.1007/5584_2020_613. PMID: 33385178.
  3. Bose B, Kapoor S, Sen U, Nihad As M, Chaudhury D, Shenoy P S. Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C (UV-C) Damage. J Vis Exp. 2020 Feb 15;(156). doi: 10.3791/59924. PMID: 32116303.
  4. As MN, Deshpande R, Kale VP, Bhonde RR, Datar SP. Establishment of an in ovo chick embryo yolk sac membrane (YSM) assay for pilot screening of potential angiogenic and anti-angiogenic agents. Cell Biol Int. 2018 Nov;42(11):1474-1483. doi: 10.1002/cbin.11051. Epub 2018 Sep 11. PMID: 30136736.