RESEARCH SCHOLARS

Rex D. A. B.

ICMR-SRF
  • Core Skills:
    Proteomics
  • MSc (Area): Biochemistry
  • MPhil (Area): Biochemistry
  • PGDBI (Area): Bioinformatics
  • rexprem@yenepoya.edu.in

Profile

Rex D. A. B studied Biochemistry at both under- and post-graduate level from Madurai Kamaraj University and Bharathidasan University respectively. He did a commendable cardiovascular research during his M.Phil dissertation at Bharathiar University. His research interests include Molecular Parasitology, Cardiovascular, and Neurodegenerative disorders. His technical expertise includes transfection of malarial parasite cell lines like 3D7, D10, NF54 Line E, and gene editing techniques such as CRISPR- Cas 9, Aptamers, and glms (ribozyme). He is currently working in Mass spectrometry-based proteomic analysis.

Experience

S.No. Positions held Name of the Institute
1 Project Assistant (DST Funded Project)

 

PSG College of Technology
2 Project Fellow (DST Funded Project) ICMR-National Institute of Traditional Medicine (NITM)
3 Senior Research Fellow Yenepoya

(Deemed to be University)

Awards/Honors

Best Poster award at 87th Annual meeting and Conference of Society of Biological Chemists (India)

Research

Research interest/Area

Molecular Parasitology, cardiovascular, and neurodegenerative disorders

Research

Our current work to identify temporal signaling events induced by IL-33 using a quantitative proteomic approach by using high- throughput techniques such as mass spectrometry (MS) to identify large-scale identification of proteins possible. This comprehensive proteomic analysis will generate a resource of IL-33-mediated changes covering early as well as late signaling events, such as recruitment of adaptors to the activated receptor, phosphorylation of downstream proteins, and alterations in protein abundance. Some of the proteins identified in the study may even be associated with inflammatory and pathological conditions and these may serve as diagnostic markers in several pathological conditions including cancer, inflammatory diseases, autoimmune deficiency and infectious diseases.

Publications

  • Marek Ostaszewski, Anna Niarakis, Alexander Mazein, Inna Kuperstein, Robert Phair, …, D. A. B. Rex, …, Reinhard Schneider. COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms. Mol Syst Biol. 2021.
  • Antil, N., Kumar, M., Behera, S. K., Arefian, M., Kotimoole, C. N., Rex, D. A. B. and Prasad, T. S. K. (2021). Unraveling Toxoplasma gondii GT strain virulence and new protein-coding genes with proteogenomic analyses. OMICS: A Journal of Integrative Biology. In press.
  • Dagamajalu, S., Rex, D. A. B., Suchitha G. P., Rai, B. A., Rainey, J. K., and Prasad, T. S. K. (2021). The network map of Elabela signaling pathway in physiological and pathological conditions. Journal of cell communication and signaling. In press.
  • Sarma, A., Dhandapani, G., Rex, D. A. B., Thoduvayil, S., Phukan, H., Kumar, M., Pinto, S. M., Prasad, T. S. K. and Madanan, M. G. (2021). Extracellular proteome analysis shows the abundance of Histidine kinase sensor protein (LIC_11528), DNA helicase (LIC_11624), Putative lipoprotein (LIC_10713) and Peptidase C39 domain protein (LIC_10511) in Leptospira interrogans grown in EMJH medium. Pathogens. In press.
  • Aravind, A., Palollathil, A., Rex, D. A. B., Kumar, K. M. K., Vijayakumar, M., Shetty, R., Codi, J. A. K., Prasad, T. S. K. and Raju, R. (2021). A multi-cellular molecular signaling and functional network map of C-C Motif Chemokine Ligand 18 (CCL18): A chemokine with immunosuppressive and pro-tumor functions. Journal of Cell Communication and Signaling. In press.
  • Rex, D. A. B., Dagamajalu, S., Raju, R., Kandasamy, R. K. and Prasad, T. S. K. (2021). SARS-CoV-2 signaling pathway map: A functional landscape of molecular mechanism in COVID-19. Journal of Cell Communication and Signaling. In press.
  • Rex, D. A. B., Kumar, S. T. A., Modi, P. K. and Prasad, T. S. K. (2021). Broadening COVID-19 Interventions to Drug Innovation: Neprilysin Pathway as a Friend, Foe or Promising Molecular Target? OMICS: A Journal of Integrative Biology. In press
  • Najar, M. A., Rex, D. A. B., Modi, P. K., Agarwal, N., Dagamajalu, S., Karthikkeyan, G., Vijayakumar, M., Chatterjee, A., Sankar, A., Prasad, T. S. K. (2020). A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway. Journal of Cell Communication and Signaling. 10.1007/s12079-020-00592-1.
  • Dagamajalu, S., Vijayakumar, M., Shetty, R., Rex, D. A. B., Narayana Kotimoole, C., Prasad, T. S. K. (2020). Proteogenomic examination of esophageal squamous cell carcinoma (ESCC): new lines of inquiry. Expert Review of Proteomics. 10.1080/14789450.2020.1845146.
  • Dagamajalu, S., Rex, D. A. B., Palollathil, A., Shetty, R., Bhat, G., Cheung, L.W.T and Prasad, T. S. K. (2020). A pathway map of AXL receptor-mediated signaling network. Journal of Cell Communication and Signaling. 10.1007/s12079-020-00580-5.
  • Thoduvayil, S., Dhandapani, G., Brahma, R., Rex, D. A. B., Mangalaparthi, K. K., Patel, K., Kumar, M., Tennyson, J., Satheeshkumar, P. K., Kulkarni, A., Pinto, S. M., Prasad, T. S. K. and Madanan, M. G. (2020). Triton X-114 fractionated subcellular proteome of Leptospira interrogans shows selective enrichment of pathogenic and outer membrane proteins in the detergent fraction. Proteomics. 19-20:e2000170. 
  • Dagamajalu, S., Rex, D. A. B., Gopalakrishnan, L., Karthikkeyan, G., Gurtoo. S., Modi, P. K., Mohanty, V., Rahiman, M., Soman, S., Raju, R., Tiwari, V. and Prasad, T. S. K. (2020). A network map of endothelin mediated signaling pathway. Journal of Cell Communication and Signaling. 10.1007/s12079-020-00581-4.
  • Gouda, M., Rex D. A. B., Sindu, P. E. S., Modi, P. K., Chanderasekaran, J., Bhandary, Y. P. (2020). Proteomics analysis revealed the importance of inflammation-mediated downstream pathways and the protective role of curcumin during bleomycin-induced pulmonary fibrosis in C57BL/6 mice. Journal of Proteome Research. 8, 2950-2963.
  • Advani, J., Verma, R., Chatterjee, O., Rex, D. A. B, R., Najar, M. A., Ravishankara, N., Suresh, S., Pachori, P. K., Gupta, U. D., Pinto, S. M., Chauhan, D. S., Tripathy, S. P., Gowda, H. & Prasad, T. S. K. 2019. Rise of Clinical Microbial Proteogenomics: A Multiomics Approach to Nontuberculous Mycobacterium-The Case of Mycobacterium abscessus UC22. OMICS, 23, 1-16.
  • Pinto, S. M., Subbannayya, Y., Rex, D. A. B., Raju, R., Chatterjee, O., Advani, J., Radhakrishnan, A., Keshava Prasad, T. S., Wani, M. R. & Pandey, A. 2018. A network map of IL-33 signaling pathway. J Cell Commun Signal, 12, 615-624.
  • Rex D.A.B. Selenium Enriched Mushrooms as a Food Supplement for Prevention of Neurodegenerative Diseases.International Journal of Pharmacy and Pharmaceutical Sciences. Vol 6 Issue 10, Nov 2014
  •  Rex D.A.B, R .Raj Kumar.Growth of nanotechnology in targeting carcinogens – a comparision on synthesis of gold and Zinc Nanoparticles. Journal of Biomaterials and Tissue Engineering Vol. 4, 1–9, 2014.. (American Scientific Publishers). DOI: http://dx.doi.org/10.1166/jbt.2014.1217
  • Rex D. A. B and Ragavan B .Studies on Phytochemicals, Antioxidant and cytotoxicity effect of Hybanthus enneaspermus. International Journal of Pharmacy and Pharmaceutical Sciences, Vol 6, Issue 6, 2014, 567-572.
  • Karthikeyan A, Siva G, Sujitha S P, Rex D. A. B and Chidambaranathan N. Development of Anti hyperglycemic activity of the ethanolic seed extract of Vernonia anthelminticum wild. International Journal of Green Pharmacy 2008; 10: 209 – 211.DOI: 10.4103/0973-8258.44733
  • Gouda, M., Rex D. A. B., Sindu, P. E. S., Modi, P. K., Chanderasekaran, J., Bhandary, Y. P. (2020). Proteomics analysis revealed the importance of inflammation-mediated downstream pathways and the protective role of curcumin during bleomycin-induced pulmonary fibrosis in C57BL/6 mice. Journal of Proteome Research.
  • Pati, S., Yadav, P., Kumari, G., Rex, D.A.B., Goswami, S., Garg, S., Prasad, T. S. K., and Ramalingam, S. (2020). Role of RBC membrane protein palmitoylation in regulation of molecular topology and susceptibility to Plasmodium falciparum invasion. bioRxiv.
  • Rex, D. A. B., Agarwal, N., Prasad, T. S. K., Kandasamy, R. K., Subbannayya, Y. and Pinto, S. M. (2019). A comprehensive pathway map of IL-18-mediated signalling. Journal of Cell Communication and Signaling.
  • Kulkarni, S., Abdulla, R., Jose, M., Adyanthaya, S., Rex, D.A.B., Patil, A. H., Pinto, S.M., Subbannayya, Y. (2019). Data-driven analysis identifies laminin-integrin-mediated signaling pathway as a determinant for cell differentiation in oral squamous cell carcinoma. Indian Journal of Pathology and Microbiology.

 

 

 

Patent

  • Prasad, T. S. K, Rex, D. A. B and Kumar, S. T. A. Composition for wound healing. Indian Patent; Reg No: 202141036627