The Yenepoya Research Centre (YRC), established in 2008, is a constituent unit of Yenepoya (Deemed to be University). YRC is devoted to multidisciplinary research spanning fundamental, applied, and translational research. YRC has state-of-the-art facilities and resources to foster cutting-edge research and innovation involving various stakeholders. The Centre adheres to the highest ethical standards, research integrity, follows Good Laboratory Practices, and holds ISO 17025:2017 compliance certification.The biomedical research at YRC is complemented with the Yenepoya Medical College Hospital with super-speciality departments and other constituent institutions, including those specialising in alternative medicine. The passionate research team with international experience under a collaborative and inclusive environment drives the achievements by adpating transformative emerging technologies. The academic programs offered by YRC lays a robust foundation for a promising R&D career in academia and industry, as evidenced by the global alumni presence. YRC plays a pivotal role in promoting entrepreneurship among students and faculties through the Yenepoya Technology Incubator. The research thrust areas align with the nation’s effort in achieving the United Nations Sustainable Development Goals, while addressing the challenging issues at regional and national priority areas.

Vision

To generate new knowledge towards national development through quality research integrated with the highest ethical standards

Mission
  • To engage in high quality research integrating both basic and translational research across multiple disciplines, driving towards therapeutics of human health

  • To cultivate critical thinking that can spark creativity and innovation among students and young researchers to make them leaders in the field of science and technology

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FACULTY

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PUBLICATIONS

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News and Updates

Achievements

Publications

  1. Mitra, A., Mandal, S., Bose, B., & Shenoy P, S. (2024). Unlocking the Potential of Obestatin: A Novel Peptide Intervention for Skeletal Muscle Regeneration and Prevention of Atrophy. Molecular biotechnology, 66(5), 948–959.
  2. Maske VB, Sarode SC, Rekadwad BN. Sequence-based analysis of tyrosinase-producing bacteria for rapid identification, differentiation, and comparison. Acta Microbiologica Bulgarica (Society of Microbiology, Bulgaria) 2024.
  3. Munjal A, Rex DA, Garg P, Prasad TSK, Mishra SK, Malhotra Y, et al. Mass Spectrometric and Artificial Intelligence_Based Identification of the Secretome of Plasmodium falciparum Merozoites to Provide Novel Candidates for Vaccine Development Pipeline. PROTEOMICS–Clinical Applications. 2024 July 31;e202300115.
  4. Anjanayya G, Gani R, Kudva A, Joshi S, Hiremath M, Kavital A, et al. Synthesis of novel oxadiazole derivatives: DFT calculations, molecular docking studies, and in vitro, in vivo evaluation of antidiabetic activity using Drosophila melanogaster model. Journal of the Iranian Chemical Society. 2024 Jul 26:1-7.
  5. Kakunje S, Badiadka N, Balladka Kunhanna S, Mahammad S, Rekha PD, Bikrodi Sesappa D, et al. Fabrication, Characterization and In Vitro Drug Release Behavior of Electrospun Eudragit/Eugenol Nanofibrous Scaffold. Fibers and Polymers. 2024;25(8):2817-33.
  6. Ramesh P, Nisar M, Ammankallu S, Babu S, Nandakumar R, Abhinand CS, et al. Delineating protein biomarkers for gastric cancers: A catalogue of mass spectrometry-based markers and assessment of their suitability for targeted proteomics applications. Journal of Proteomics. 2024;306:105262.
  7. Kunnath AN, Parker SK, Crasta DN, Kunhiraman JP, Madhvacharya VV, Kumari S, et al. Metformin augments major cytoplasmic organization except for spindle organization in oocytes cultured under hyperglycemic and hyperlipidemic conditions: An in vitro study. Toxicology and Applied Pharmacology. 2024;490:117039.
  8. Pai AA, Upadhyay SS, Thattai AK, Parate SS, Illangeswaran RS, Renji RM, et al. Global Plasma Metabolomic Profiling Reveals Dysregulated Lipid Metabolism in Patients with Hepatic Sinusoidal Obstruction Syndrome-a Pilot Biomarker Study. Transplantation and Cellular Therapy. 2024 Feb 1;30(2):S166.
  9. Sasikumar J, Laha S, Naik B and Das SP. Enhanced visualization of Nuclear Staining and Cell Cycle analysis for the human commensal Malassezia. Scientific Reports. 2024.
  10. Vasvani S, Vasukutty A, Bardhan R, Park IK, Uthaman S. Reactive oxygen species driven prodrug-based nanoscale carriers for transformative therapies. Biomaterials Science. 2024 July23;12:4335-4353.
  11. Ashaiba A, Sapna K, Arun AB, Tellis RC, Prasad KS. Development and Evaluation of a Noninvasive Microfluidic-Based Paper Analytical Device for Leptospirosis Diagnosis. Analytical Chemistry. 2024 Jul 11;96(29).
  12. Deshpande NS, Udayakumar D, Prabhu A, Rani V, Dixit SR, Singh D, Revanasiddappa BC. Synthesis, Molecular Docking, MD Simulation and Evaluation of Anticancer Activity of Novel 1, 3, 4-Oxadiazole Derivatives against Ehrlich Ascites Carcinoma (EAC) Cell Lines. Journal of Computational Biophysics and Chemistry. 2024;23(4):519-39.
  13. Ganavi D, Kumar V, Akhileshwari P, Prabhu A, Omantheswara N, Mahendra M, Poojary B. Synthesis, crystal structure, Hirshfeld, DFT, molecular docking, dynamics studies, and anti-cancer activity of 1-substituted-2-(4-(diethylamino)-2-hydroxyphenyl)-1H-benzo [d] imidazole-5-ethyl carboxylates. Journal of Molecular Structure. 2024;1314:138657.
  14. Sheeraz AS, Aiswarya E, Kumara BN, Sonia J, Rodrigues RV, Sheikh N, et al. Additive Manufactured Paper-PMMA Hybrid Microfluidic Chip for Simultaneous Monitoring of artificial urine Creatinine and pH. Analyst. 2024 Jul22;149(15): 3882-3890.
  15. Rao S, Surya S, Pavan SR, Ali S, Prabhu A, Ginjupalli K, et al. Biocompatibility of polymethyl methacrylate heat-polymerizing denture base resin copolymerized with antimicrobial monomers. Journal of Prosthetic Dentistry. 2024 Jul 13:S0022-3913(24)00433-5.
  16. Banerjee S, K MH, Shastry RP. Loop-mediated isothermal amplification (LAMP) assay for early on-site detection of Group B Streptococcus infection in neonatal sepsis blood sample. Molecular Biology Molecular biology reports. 2024 Jul 13:51(1): 811.
  17. Vijayakumar P, Mishra A, Deka RP, Pinto SM, Subbannayya Y, Sood R, et al. Proteomics analysis of duck lung tissues in response to highly pathogenic avian influenza virus. Microorganisms. 2024 Jul;12(7):1288.
  18. Suchithra KV, Hameed A, Surya S, Mahammad S, Arun AB. Dual phage-incorporated electrospun polyvinyl alcohol-eudragit nanofiber matrix for rapid healing of diabetic wound infected by Pseudomonas aeruginosa and Staphylococcus aureus. Drug Delivery and Translational Research. 2024 Jul 9:1-7.
  19. Mishra D, Shekhar S, Subba P, Prasad TSK, Chakraborty S, Chakraborty N. Wheat TaNAC_18 functions as a positive regulator of high_temperature adaptive responses and improves cell defense machinery. The Plant Journal. 2024 Jul 3.
  20. Banjan B, Vishwakarma R, Ramakrishnan K, Dev RR, Kalath H, Kumar P, et al. Targeting AFP-RAR_ complex formation: a potential strategy for treating AFP-positive hepatocellular carcinoma. Molecular Diversity. 2024 Jul 2:1-6.
  21. Aravind A, Nandakumar R, Ahmed M, Nisar M, Palollathil A, Kanichery A, et al. REMEMProt: a resource of membrane-enriched proteome profiles, their disease associations, and biomarker status. Life Science Alliance. 2024 Jul 1;7(7).
  22. Shastry RP, Bajire SK, Banerjee S, Shastry KP, Hameed A. Association Between Biofilm Formation and Extended-Spectrum Beta-Lactamase Production in Klebsiella pneumoniae Isolated from Fresh Fruits and Vegetables. Current Microbiology. 2024 Jul;81(7):206.
  23. Naik B, Sasikumar J, Das SP. From Skin and Gut to the Brain: The Infectious Journey of the Human Commensal Fungus Malassezia and Its Neurological Consequences. Molecular Neurobiology. 2024 Jun 14:1-24.
  24. Jain S, Sonia J, Prashanth S, Sanjeeva SG, Prasad KS, Johnson RP. Polytyrosine-Coated Paper Electrode for Sensitive and Selective Sensing of NADH. Langmuir. 2024 Jun 13.40 (25).
  25. Krishna SM, Prabhu SM, Das R. Unraveling the propensity of various genetic disorders and syndromes in the Koraga, an aboriginal tribe from southern India. Journal of Biosciences. 2024 49:67
  26. Shastry RP, Ghate SD, Hameed A, Rao RS, Bhandary YP, Shetty R. Emergence of rare and low abundant anaerobic gut Firmicutes is associated with a significant downfall of Klebsiella in human colon cancer. Microbial Pathogenesis. 2024 Jun 6:106726.
  27. Sampathkumar J, Dalavi PA, Venkatesan J, Amaladoss N, Rajamanickam R. Synthesis, spectroscopic, SC-XRD, DFT, RAHBs, RDG, molecular docking and in vitro anticancer evaluation of ethyl 1, 2, 5, 6-tetrahydro-4_hydroxy-2, 6-diphenylpyridine-3-carboxylate. Journal of Molecular Structure. 2024 Jun 5;1305:137731.
  28. Rekadwad BN, Gonzalez JM, Li WJ. Last universal common ancestor and origin of life: what uncultivated Bacteria, Archaea, and extremophiles can tell us. Frontiers in Microbiology. 2024 Jun 3;15:1412625.
  29. Shetty M, Naik B, Das SP. Rice bran oil supports robust growth of the commensal fungus Malassezia. The Microbe. 2024 Jun 1;3:100080.
  30. Rekadwad BN. 1, 4, 5, 6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid (THMP)–A novel universal stress protein data from Halomonas species for pharmaceutical applications. Data in Brief. 2024 Jun 1;54:110272.
  31. Usha T, Hemavathi KN, Goyal AK, Abhinand CS, Dhivya S, Cholarajan A, et al. Investigating emodin derivatives against SARS-CoV-2 found in medicinal herbs. Kuwait Journal of Science. 2024 May 31;51(4):100265.
  32. Parate SS, Upadhyay SS, Karthikkeyan G, Pervaje R, Abhinand CS, Modi PK, Prasad TSK. Comparative Metabolomics and Network Pharmacology Analysis Reveal Shared Neuroprotective Mechanisms of Bacopa monnieri (L.) Wettst and Centella asiatica (L.) Urb. Molecular Neurobiology. 2024 May 30:1-23.
  33. Kar B, Shanavas S, Karmakar A, Nagendra AH, Vardhan S, Sahoo SK, et al. 2-Aryl-1 H-imidazo [4, 5-f][1, 10] phenanthroline-Based Binuclear Ru (II)/Ir (III)/Re (I) Complexes as Mitochondria Targeting Cancer Stem Cell Therapeutic Agents#. Journal of Medicinal Chemistry. 2024 May 29; 67(13) 10928–10945.
  34. Kumara BN, Shambhu R, Shim YB, Prasad KS. Lysozyme activated co-delivery of latanoprost–timolol from mucoadhesive chitosan nanocomposite to manage glaucoma. RSC Pharmaceutics. 2024 May 22; 1:548-569.
  35. Vollset SE, Ababneh HS, Abate YH, Abbafati C, Abbasgholizadeh R, Abbasian M, et al. Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021. The Lancet. 2024 May 18;403(10440):2204-56.
  36. Naghavi M, Ong KL, Aali A, Ababneh HS, Abate YH, Abbafati C, et al. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet. 2024 May 18;403(10440):2100-32.
  37. Bhattacharjee NV, Schumacher AE, Aali A, Abate YH, Abbasgholizadeh R, Abbasian M, et al. Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021. The Lancet. 2024 May 18;403(10440):2057-99.
  38. Banjan B, Raju R, Prasad TSK, Abhinand CS. Computational identification of potential bioactive compounds from Triphala against alcoholic liver injury by targeting alcohol dehydrogenase. Molecular Diversity. 2024 May 14:1-6.
  39. Yu Jiao J, Abdugheni R, Zhang DF, Ahmed I, Ali M, Chuvochina M, et al. Advancements in prokaryotic systematics and the role of Bergeys International Society for Microbial Systematics (BISMiS) in addressing challenges in the meta-data era. National Science Review. 2024 May 13:nwae168.
  40. Vasishta S, Ammankallu S, Umakanth S, Prasad TSK, Joshi MB. DNA methyltransferase isoforms regulate endothelial cell exosome proteome composition. Biochimie. 2024 May 10;223:98-115.
  41. Thimmappa PY, Nair AS, Dsilva S, Aravind A, Mallya S, Soman SP, et al. Neutrophils display distinct post-translational modifications in response to varied pathological stimuli. International Immunopharmacology. 2024 May 10;132:111950.
  42. Rekadwad BN, Shouche YS, Jangid K. A culture-independent approach, supervised machine learning, and the characterization of the microbial community composition of coastal areas across the Bay of Bengal and the Arabian Sea. BMC microbiology. 2024 May 10;24(1):162.
  43. Varughese A, Balnadupete A, Ramesh P, Prasad TSK, Nidha AB, Bhandary Y. Guardians Turned Culprits: NETosis and Its Influence on Pulmonary Fibrosis Development. Molecular Biotechnology. 2024 May 8:1-3.
  44. Mahin A, Chikmagalur Ravindra S, Ramesh P, Naik P, Raju R, Prasad TSK, Abhinanad CS. Unveiling Actin Cytoskeleton Role in Mediating Chikungunya-Associated Arthritis: An Integrative Proteome–Metabolome Study. Vector-Borne and Zoonotic Diseases. 2024 May 7.
  45. Nagaraj A, Subramaniyan Y, Surya S, Rekha PD. Burn Wound Healing Abilities of a Uronic Acid Containing Exopolysaccharide Produced by the Marine Bacterium Halomonas malpeensis YU-PRIM-29 T. Applied Biochemistry and Biotechnology. 2024 May 3:1-24.
  46. Rekadwad BN. The reverse zoonosis transfer cycle from the human-animal-plant-environment interface: How antibiotic-resistant bacteria from humans threaten the environment and fuel the rise of superbugs. Medical Hypotheses. 2024 May 1;186:111334.
  47. Priyanka P, Gopalakrishnan AP, Nisar M, Shivamurthy PB, George M, John L, et al. A global phosphosite-correlated network map of Thousand And One Kinase 1 (TAOK1). The International Journal of Biochemistry & Cell Biology. 2024 May 1;170:106558.
  48. Mathew S, Kumar KV, Prabhu A, Shastry RP, Rajesh KS. Braided silk sutures coated with photoreduced silver nanoparticles for eradicating Staphylococcus aureus and Streptococcus mutans infections. Journal of Microbiological Methods. 2024 May 1;220:106923.
  49. Daniel Thomas S, Vijayakumar K, John L, Krishnan D, Rehman N, Revikumar A, et al. Machine learning strategies in microRNA research: bridging genome to phenome. OMICS: A Journal of Integrative Biology. 2024 May 1;28(5):213-33.
  50. Pavan SR, Prabhu A. Novel pH responsive hesperidin nanoformulation exerts anticancer activity on lung adenocarcinoma cells by targeting Akt/mTOR and MEK/ERK pathways. Journal of Materials Research. 2024 Apr 28;39(8):1217-31.
  51. Suchitha GP, Devasahayam Arokia Balaya R, Prasad TSK, Dagamajalu S. A signaling network map of Lipoxin (LXA4): an anti-inflammatory molecule. Inflammation Research. 2024 Apr 26:1-8.
  52. Suchitha GP, Dagamajalu S, Prasad TSK, Devasahayam Arokia Balaya R. A Comprehensive Network Map of Interleukin-26 Signaling Pathway. Journal of Interferon & Cytokine Research. 2024 Apr 19.
  53. Singh I, Hoti SL, Chauhan N, Joshi RK, Prasad TSK, Sarikhani M, et al. Immunomodulation of streptozotocin induced Type 1 diabetes mellitus in mouse model by Macrophage migration inhibitory factor-2 (MIF-2) homologue of human lymphatic filarial parasite, Wuchereria bancrofti. Acta Tropica. 2024 Apr 1;252:107142.
  54. Miliotis G, Sengupta P, Hameed A, Chuvochina M, McDonagh F, Simpson AC, et al. Novel spore-forming species exhibiting intrinsic resistance to third-and fourth-generation cephalosporins and description of Tigheibacillus jepli gen. nov., sp. nov. Mbio. 2024 Apr 10;15(4):e00181-24.
  55. Aziz RA, Ramesh P, Suchithra KV, Stothard P, Narayana VK, Raghu SV, et al. Comprehensive insights into the impact of bacterial indole-3-acetic acid on sensory preferences in Drosophila melanogaster. Scientific Reports. 2024 Apr 9;14(1):8311.
  56. Kumara BN, Naveen MH, Sonia J, Rafi M, Bang JH, Prasad KS. A simple naked eye detection of Pb2+ on a gold nanocluster decorated disposable paper spot arrays. Physica Scripta. 2024 Apr 9;99(5):055526.
  57. Subramaniyan Y, Khan A, Mujeeburahiman M, Rekha PD. High Incidence of Antibiotic Resistance in the Uropathogenic Bacteria Associated with Different Urological Diseases and Metabolic Complications: A Single Center Cross-Sectional Study. Microbial Drug Resistance. 2024 Apr 8;30(6).
  58. Kumar P, Anne G, Ramesh MR, Doddamani M, Prabhu A. Enhancing the functionality of biodegradable Mg–Zn–Mn alloys using poly (lactic) acid (PLA) coating for temporary implants. Journal of Coatings Technology and Research. 2024 Apr 1:1-3.
  59. Shaikh SB, Prabhu A, Akarsha B, Rahamathulla MP, Sha M, Bhandary YP. Lung as a target for COVID-19: Mechanistic insights and probable candidate molecules for cure. Journal of Infection and Public Health. 2024 Apr 1;17(4):573-8.
  60. Kailasam V, Kumara BN, Prasad KS, Nirmal J. Combination of self-assembling system and N, O-carboxymethyl chitosan improves ocular residence of anti-glaucoma drug. European Journal of Pharmaceutics and Biopharmaceutics. 2024 Apr 1;197:114208.
  61. Rani JM, Akkarshana P, Neelaveni V, Mohan S, Rekha PD, Rao RM, Muthulakshmi L. Evaluation of the inhibitory potential of bioactive compounds against SARS-CoV-2 by in silico approach. Journal of Molecular Modeling. 2024 Mar;30(3):60.
  62. Palatty PL, Sacheendran D, Raghu SV, Arora R, Rao S, Baliga MS. Dietary agents in the prevention of radiation-induced nausea and vomiting (RINV): review addressing the scientific observations, benefits, lacunae and future direction. International Journal of Radiation Biology. 2024 Mar 19:1-2.
  63. Rao RM, El Dhaybi I, Cadet F, Etchebest C, Diharce J. The mutual and dynamic role of TSPO and ligands in their binding process: An example with PK-11195. Biochimie. 2024 Mar 16:S0300-9084(24)00067-1.
  64. Shaji V, Dagamajalu S, Sanjeev D, George M, Kanekar S, Prasad G, et al. Deciphering the Receptor-Mediated Signaling Pathways of Interleukin-19 and Interleukin-20. Journal of Interferon & Cytokine Research. 2024 Mar 6.
  65. Shabeena M, Warale D, Prabhu A, Kouser S, Manasa DJ, Nagaraja GK. Pectin wrapped halloysite nanotube reinforced Polycaprolactone films for potential wound healing application. International Journal of Biological Macromolecules. 2024 Mar 1;262:130140.
  66. Singh I, Kanichery A, Kotimoole CN, Modi PK, Prasad TSK, Hoti SL. Unpacking Immune Modulation as a Site of Therapeutics Innovation for Nematode Parasite Wuchereria bancrofti: A Temporal Quantitative Phosphoproteomics Profiling of Macrophage Migration Inhibitory Factor 2. OMICS: A Journal of Integrative Biology. 2024 Mar 1;28(3):125-37.
  67. Hemavathi KN, Skariyachan S, Raju R, Prasad TSK, Abhinand CS. Computational screening of potential anti-inflammatory leads from Jeevaneeya Rasayana plants targeting COX-2 and 5-LOX by molecular docking and dynamic simulation approaches. Computers in Biology and Medicine. 2024 Mar 1;171:108164.
  68. Roshni PT, Rekha PD. Biotechnological interventions for the production of forskolin, an active compound from the medicinal plant, Coleus forskohlii. Physiology and Molecular Biology of Plants. 2024 Feb;30(2):213-26.
  69. Gupta P, Goswami SG, Kumari G, Saravanakumar V, Bhargava N, Rai AB, et al. Development of pathophysiologically relevant models of sickle cell disease and _-thalassemia for therapeutic studies. Nature Communications. 2024 Feb 27;15(1):1794.
  70. Pavan SR, Prabhu A. Acid Degradable Zinc Oxide Nanoparticle Loaded Etoposide Nanoformulation for Targeting Lung Adenocarcinoma via Drug Metabolism and Crosstalk Between Angiogenesis and Akt Pathways. BioNanoScience. 2024 Feb 26:1-2.
  71. Naik B, Sasikumar J, Das SP. Fungal coexistence in the skin mycobiome: a study involving Malassezia, Candida, and Rhodotorula.AMB Express. 2024 Feb 20;14(1):26.
  72. Devasahayam Arokia Balaya R, Palollathil A, Kumar ST, Chandrasekaran J, Upadhyay SS, Parate SS, et al. Role of Hemigraphis alternata in wound healing: metabolomic profiling and molecular insights into mechanisms. Scientific Reports. 2024 Feb 16;14(1):3872.
  73. Rekadwad BN, Shouche YS, Jangid K. Community characterization of soil from the Central Deccan Plateau dry tropical deciduous forest (Ceddtrof) in central India using 16S rRNA gene amplicon sequencing. Microbiology Resource Announcements. 2024 Feb 15;13(2):e01134-23.
  74. Kotimoole CN, Ramya VK, Kaur P, Reiling N, Shandil RK, Narayanan S, et al. Discovery of Species-Specific Proteotypic Peptides To Establish a Spectral Library Platform for Identification of Nontuberculosis Mycobacteria from Mass Spectrometry-Based Proteomics. Journal of Proteome Research. 2024 Feb 15;23(3):1102-17.
  75. Sequeira JJ, Vinuthalakshmi K, Das R, van Driem G, Mustak MS. The maternal U1 haplogroup in the Koraga tribe as a correlate of their North Dravidian linguistic affinity. Frontiers in Genetics. 2024 Feb 7;14:1303628.
  76. Kumara BN, Velmurugan K, Ghate MV, Shambhu R, Nirmal J, Prasad KS. A promising single and dual drug-nanocomposite enriched contact lens for the management of glaucoma in response to the tear fluid enzyme. Journal of Materials Chemistry B. 2024 Feb 2;12(9):2394-2412.
  77. Murugan SS, Hur W, Son SE, Lee HB, Ha CH, Lee SJ, Cheon SH, Jeon SM, Venkatesan J, et al. The therapeutic efficacy of silver loaded rhenium disulfide nanoparticles as a photothermal agent for cancer eradication. Journal of Photochemistry and Photobiology B: Biology. 2024 Jan 1;250:112831.
  78. Shaheer K, Prabhu BS, Ali HS, Lakshmanan-M D. Breast cancer cells are sensitized by piperine to radiotherapy through estrogen receptor-_ mediated modulation of a key NHEJ repair protein-DNA-PK. Phytomedicine. 2024 Jan 1;122:155126.
  79. Lakshmanan-M D, Shabeer AH. Remdesivir may hinder the function of Recombination Activating Gene-1 (RAG1). Medical Hypotheses. 2024 Jan 1;182:111228.

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