Dr. Bipasha Bose
PhD, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), India
Dr Bipasha Bose obtained her PhD degree in Applied Biology (Molecular Carcinogenesis) from the most premier Cancer Institute in India, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, in 2004. She has about 15 years of post-PhD research experience working in Stem Cell Biology, in academia and industry in India, Belgium and Singapore with the capacities of Group Leader, Senior Research Scientist, Senior Post doctoral fellow and Tenured Faculty. Out of these 16 years of post-PhD research experience, Dr Bose has carried out her research for almost nine years in globally ranked international laboratories/institutes. The institutes where Dr Bose worked previously are The Stem Cell Institute in the Catholic University of Leuven Belgium (world ranking 40 as per QS World University Ranking) and Nanyang Technological University, Singapore (world ranking 13 as per QS World University Ranking).
Dr Bose holds essential skills in the field of clinical, as well as, R and D grade stem cells. Her noted contributions to the field of regenerative medicine involve her co-work with the scientists for deriving human embryonic stem cells (hESC) for the first time from the Indian subcontinent, differentiation of hESC into functional insulin producing β islets and their pre-clinical translation, differentiation of hESC into functional hepatocytes. She has also contributed in the field of adult stem cell biology and proven the myogenic potential of aged muscle stem cells and perivascular mesenchymal stem cells, hepatocyte differentiation from Multipotent Adult Progenitor cells. Her contribution in the field of basic biology of stem cells has proven the pluripotent conversion of myostatin- null muscle stem cells without using reprogramming factors. She has contributed to several publications and book chapters as the lead author of the peer-reviewed journals and books of international repute. Dr Bose also has two patents, several research grants from Indian Governmental agencies to her credit. Dr Bose has also received several awards, such as EMBO travel award for the 2018 Stem Cell Conference, Singapore, travel grant/award from Department of Science and Technology, Government of India to present her work as an invited speaker in the International Conference of Tissue Engineering and Regenerative Medicine held in September 2016 in Berlin, Germany. Currently, Dr Bose is the co-in-charge of Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya University, Mangalore, India. Her present focus is on establishing R and D scale human and mouse stem cell research, guiding PhD students and driving research in her area of expertise. Her ongoing research projects involve basic biology of CD34+ stem cells for treating muscular dystrophy; pluripotent stem cell-based therapy for diabetes; muscle stem cells, various aspects of ocular stem cells and cancer stem cell therapeutics.
Other academic activities of Dr Bose involve her role as a reviewer of journals of International repute such as Stem Cells, Journal of Cellular Biochemistry, International Journal of Biochemistry and Cell Biology. Dr Bose also serves as an Editorial Board of the Journal Molecular Biotechnology published by Elsevier.
- Associate Professor (Oct 2017–till date) – Yenepoya Research Centre, Yenepoya University, Mangaluru, Karnataka, India
- Assistant Professor (Oct 2014–Sept 2017) – Yenepoya Research Centre, Yenepoya University, Mangaluru, Karnataka, India
- Research Fellow and Senior Research Fellow (Nov 2009-Mar 2014) – School of Biological Sciences, Nanyang Technological University, Singapore and Singapore Institute of Clinical Science-Brener Centre for Molecular Medicine, Singapore
- Associate Academic Staff/International Mobility postdoctoral (Jan 2008-Jul 2009) – Stem Cell Institute, Catholic University Leuven, Leuven, Belgium
- Research Scientist and Senior Research Scientist (Jan 2004-Jan 2008) – Department of Regenerative Medicine, Reliance Life Sciences Pvt. Ltd., Dhirubhai Ambani Life Sciences Centre, Navi Mumbai, India
- European Molecular Biology (EMBO) Travel Grant awarded to present the work/poster titled, “Stem Cells from mouse ocular surface exhibit resistance to Ultraviolet C (UCV) at low doses while high doses manifest the effects as downregulated Pax6 with concomitant upregulation of NFκβ pathway” in the EMBO workshop titled, “Molecular mechanisms of Developmental and Regenerative Biology, 11-13 November, 2018, Singapore.
- European Molecular Biology (EMBO) short term fellowship (90 days) awarded to my graduate student Saketh Kapoor to carry out a short term work in the University of Bari, Italy-2018
- All India 2nd rank prize (50,000 INR) awarded to my graduate student Mr Utsav Sen in Indian National level student research convention “Anveshan-2018” organized by AIU (Association of Indian Universities, New Delhi) and Chitkara University, Punjab
- Senior Research Fellowship awarded to my graduate student Mr Utsav Sen from the Indian Council of Medical Research (ICMR), Government of India to carry out our ongoing work titled “Anti breast and colon cancer therapy via modulation of cancer stem cells and its associated mechanisms”. (Ref no. ICMR/2017-3769/CMB-BMS) on Cancer Stem Cell therapeutics-2018-2020
- Best poster award for the work titled, “Early adhering fractions from muscle primary cultures are non-myogenic progenitor/ -Fibroadipogenic stem cells” presented my graduate student Mr Saketh Kapoor (first author of the study) in STEMCON-2017 organised by Nitte University, Mangalore, Karnataka, India
- Travel Grant from the Royan International Twin Congress-18th Congress of Reproductive Biomedicine-13th Congress on Stem Cell Biology and Technology, Aug 30-Sep 01, 2017, Tehran, Iran (did not avail)
- Travel Grant from Department of Science and Technology, Government of India-2017 for participation in the training programme on proteomics for women scientists in India conducted at Banaras Hindu University, Varanasi, India, Feb 02-08, 2017.
- Travel Grant from Department of Science and Technology, Government of India-2016 for oral presentation in the 5th International Conference of Tissue Engineering and Regenerative Medicine, Berlin, Germany
- Travel Grant from Department of Biotechnology, Government of India and Wellcome Trust-DBT for participation in the Young Investigator’s Meet-2016, Manesar, Haryana, India
- Qualified for the International Incoming Fellowship category of prestigious Marie Curie FP-7 European fellowship for the project submitted “Role of Dido gene complex in stem cells and cancer, Europe, 2012 with a score of 80.2%
- Qualified for the International Incoming Fellowship category of prestigious Marie Curie FP-7 European fellowship for the project submitted “Efficient generation and Expansion of hepatocyte like cells from Human Embryonic Stem Cells (hESC) and Human Induced Pluripotency Cells (hiPSC), Europe, 2008 with a score of 82.4%.
- Senior Research Fellowship, Council for Scientific and Industrial Research (CSIR), Government of India-2001-2003
- Best Poster Award, Environmental Mutagenesis Society of India, Kolkata, India -2003
- Photomicrograph of the Year Award, Thermo Shandon, Pittsburgh, USA -2002
- Junior Research Fellowship, Department of Atomic Energy, Government of India, -1997-2000
- Distinction in M.Sc Ag-Molecular Biology and Biotechnology, G.B.Pant University of Ag and Technology, Pantnagar, Nainital, India, 82.845%-1997
- Junior Research Fellowship, Department of Biotechnology, Government of India-1994-1996
Regenerative stem cells (basic biology and translational/cell therapy) and Cancer stem cells (Basic and translational/therapeutics)
Pluripotent stem cells, Adult stem cells such as CD34+ stem cells, Muscle derived stem cells (MDSCs), pluripotent conversion of MDSCs without growth factors or small molecules; Differentiation of PSC into pancreatic beta islets; Ocular surface stem cells and their role during UV/bright light induced oxidative stress, Breast and colon cancer stem cell therapeutics using vitamins and mesenchymal stem cells and tumor xenograft models.
- Sen U, Shenoy P S, Bose B*. Opposing effects of low versus high concentrations of water soluble vitamins/dietary ingredients Vitamin C and niacin on colon cancer stem cells (CSCs). Cell biology international. 2017 Oct;41(10):1127-45.
- Bose B*, Shenoy S. Pluripotent conversion of muscle stem cells without reprogramming factors or small molecules. Stem Cell Reviews and Reports. 2016 Feb 1;12(1):73-89.
- Bose B, Shenoy SP, Konda S, Wangikar P. Human embryonic stem cell differentiation into insulin secreting β‐cells for diabetes. Cell biology international. 2012 Nov;36(11):1013-20.
- Roelandt P, Pauwelyn KA, Sancho-Bru P, Subramanian K, Bose B, Ordovas L, Vanuytsel K, Geraerts M, Firpo M, De Vos R, Fevery J. Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PloS one. 2010 Aug 11;5(8):e12101.
- Mandal A, Tipnis S, Pal R, Ravindran G, Bose B, Patki A, Rao MS, Khanna A. Characterization and in vitro differentiation potential of a new human embryonic stem cell line, ReliCell® hES1. Differentiation. 2006 Mar 1;74(2-3):81-90.
- Bose B, Motiwale L, Rao KV. DNA damage and G2/M arrest in Syrian hamster embryo cells during Malachite green exposure are associated with elevated phosphorylation of ERK1 and JNK1. Cancer letters. 2005 Dec 18;230(2):260-70.
- Assessment of cellular and molecular changes with response to thoron inhalation in mice. [36(4)/14/51/2016-BRNS, DAE, Govt of India]. (43 lakhs)
- Differentiation of human pluripotent stem cells in to functional beta islets using bio-active lipids. [EMR/2017/003114, DST- SERB, Govt. of India]. (53 lakhs)
- Skeletal muscle fluorosis; effect of fluoride on skeletal muscle cells, and its associated mechanisms in-vitro and in-vivo studies. [EMR/2017/000591 DST- SERB, Govt. of India]. (32 lakhs)
U. S. Patent
- Mandal A, Tipnis S, Ravindran G, Kulkarni J, Patki A, Pal R, Bose B, Kahn AF, Khanna A, inventors; Reliance Life Sciences Pvt Ltd, assignee. Establishment of a human embryonic stem cell line using mammalian cells. United States patent US 7,811,817. 2010 Oct 12.